3D Detection of Spheric and Aspheric Femoral Heads in Coronal MR Images of Patients with Legg-Calve-Perthes Disease Using the Spherical Hough Transform

Memiş, Abbas; Albayrak, Songul; Bilgili, Fuat

doi:10.1145/3288200.3288205

Cited by 5 publications

(2 citation statements)

References 10 publications

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“…X-rays of the femoral head revealed a heterogeneous bone density, local collapse, and loss of spherical structure (Figure 1B; left). These findings were consistent with previously reported observations in children with Perthes disease (Catterall et al, 1982;Madan et al, 2003;Trostel et al, 2003;Memiş et al, 2018).…”

Section: Generation Of Rabbit Model Of Perthes Diseasesupporting

confidence: 93%

“…For model generation, the teres ligament of the femoral head of 8-week-old rabbits was disrupted, which disrupted the blood flow and resulted in the development of Perthes disease. As depicted in Figure 1, the morphology of the disrupted femoral head exhibited a loss of spherical structure, pale coloration, thickened cartilage layer, and poor gloss, which are commonly observed in children with Perthes disease (Catterall et al, 1982;Doria et al, 2008;Memiş et al, 2018;Shapiro, 2019). X-ray visualization of the femoral heads of the rabbit model revealed a heterogeneous bone density, localized collapse, and loss of spherical structure, which are also observed in children with Perthes disease (Madan et al, 2003;Rich and Schoenecker, 2013;Cheng et al, 2014).…”

Section: Discussionmentioning

confidence: 97%

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Construction of ceRNA network based on RNA-seq for identifying prognostic lncRNA biomarkers in Perthes disease

Zhang

et al. 2023

Front. Genet.

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Introduction: Legg-Calvé-Perthes disease or Perthes disease is a condition that occurs in children aged 2 to 15 years, and is characterized by osteonecrosis of the femoral head, which results in physical limitations. Despite ongoing research, the pathogenesis and molecular mechanisms underlying the development of Perthes disease remain unclear. In order to obtain further insights, the expression patterns of long non-coding RNAs (lncRNAs), miRNAs, and mRNAs in a rabbit model of Perthes disease were analyzed in this study by transcriptome sequencing.Methods and results: The results of RNA-seq analyses revealed that 77 lncRNAs, 239 miRNAs, and 1027 mRNAs were differentially expressed in the rabbit model. This finding suggested that multiple genetic pathways are involved in the development of Perthes disease. A weighted gene co-expression network analysis (WGCNA) network was subsequently constructed using the differentially expressed mRNAs (DEmRNAs), and network analysis revealed that the genes associated with angiogenesis and platelet activation were downregulated, which was consistent with the findings of Perthes disease. A competing endogenous RNA (ceRNA) network was additionally constructed using 29 differentially expressed lncRNAs (including HIF3A and LOC103350994), 28 differentially expressed miRNAs (including ocu-miR-574-5p and ocu-miR-324-3p), and 76 DEmRNAs (including ALOX12 and PTGER2).Disscusion: The results obtained herein provide novel perspectives regarding the pathogenesis and molecular mechanisms underlying the development of Perthes disease. The findings of this study can pave the way for the development of effective therapeutic strategies for Perthes disease in future.

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Section: Generation Of Rabbit Model Of Perthes Diseasesupporting

confidence: 93%