This article offers for the first time a facial approximation of the Ancient Egyptian Pharaoh Amenhotep III (reigned ca. 1388–1351 BC) based on photographic material of his mortal remains and anthropometric data collected at the time, and by adopting a novel technique previously used in similar research by our team. A comprehensive discussion of the mummy attributed to Pharaoh Amenhotep III is also annexed to the study, focusing on the bioarcheological and embalming aspects.