3D gel-printing of hydroxyapatite scaffold for bone tissue engineering

Shao, Huiping; He, Jianzhuang; Lin, Tao; Zhang, Zhinan; Zhang, Yumeng; Liu, Shuwen

doi:10.1016/j.ceramint.2018.09.300

Cited by 110 publications

(45 citation statements)

References 28 publications

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“…In this case, the maximum compressive strength and elastic modulus of sintered HAp scaffold were 16.77 ± 0.38 and 492 ± 11 MPa, respectively. In addition, scaffolds showed 10.38% rate of weight loss after the incubation in Tris-HCl solution for 5 weeks (Shao et al, 2019). Liu et al prepared sintered HAp scaffolds using digital light processing method.…”

Section: Only Hap-based Printing Materialsmentioning

confidence: 99%

Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

et al. 2019

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Hydroxyapatite (HAp) has been considered for decades an ideal biomaterial for bone repair due to its compositional and crystallographic similarity to bioapatites in hard tissues. However, fabrication of porous HAp acting as a template (scaffold) for supporting bone regeneration and growth has been a challenge to biomaterials scientists. The introduction of additive manufacturing technologies, which provide the advantages of a relatively fast, precise, controllable, and potentially scalable fabrication process, has opened new horizons in the field of bioceramic scaffolds. This review focuses on three-dimensional-printed HAp scaffolds and related composite systems, where the calcium phosphate phase is combined with other ceramics or polymers improving the mechanical properties and/or imparting special extra-functionalities. The main applications of three-dimensional-printed HAp scaffolds in bone tissue engineering are presented and discussed; furthermore, this review also emphasizes the most recent achievements toward the development and testing of multifunctional HAp-based systems combining multiple properties for advanced therapy (e.g., bone regeneration, antibacterial effect, angiogenesis, and cancer treatment).

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Section: Only Hap-based Printing Materialsmentioning

confidence: 99%

Additive Manufacturing Methods for Producing Hydroxyapatite and Hydroxyapatite-Based Composite Scaffolds: A Review

et al. 2019

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“…The authors could control the deposited strand dimensions by the hydrogel physical properties and operating parameters and achieved a mechanically stable scaffold with high cell viability (> 97%). The effect of printing speed on HA slurry with a solid volume fraction of 55% showed that the printing speed affected the shape and printing quality of the final scaffold [277]. A low print speed (3 mm/s) could not match the amount of extruding slurry and the printed lines piled up resulting in wider lines and smaller scaffold pore size than the actual model.…”

Section: D Printing Process Optimizationmentioning

confidence: 98%

Challenges on optimization of 3D-printed bone scaffolds

Bahraminasab

2020

BioMed Eng OnLine

161

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Background Bones in human body are prone to damage due to different causes such as fractures, diseases, and infections. Nevertheless, they have a remarkable capacity to repair and heal themselves after trauma and illness. Large defects, however, are never completely reinstated because their sizes are beyond the limit up to which the bones can repair [1]. In these conditions, therefore, a medical remedy is required to stabilize, align and support the damaged bone region to restore the lost function. Bone autografts are considered the gold standard treatment. However, they have a number of shortcomings including the limited sources and donor site morbidity. Allografts also have the risk of immune rejection and disease transmission [2, 3]. Therefore, the research has headed for other solutions via tissue engineering. Bone tissue engineering provides three-dimensional (3D)

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“…309 Tissue engineering involves the growth of functional bioconstructs on 3D scaffolds. [310][311][312] On the other hand, TERM is used to regenerate and repair/heal/replace the damaged tissues or organs. 309 TERM serves as an effective substitute to clinical organ transplantation.…”

Section: Nanoscale Advancesmentioning

confidence: 99%