Simulation of a geostratigraphic unit is of vital importance for the study of geoinformatics, as well as geoengineering planning and design. A traditional method depends on the guidance of expert experience, which is subjective and limited, thereby making the effective evaluation of a stratum simulation quite impossible. To solve this problem, this study proposes a machine learning method for a geostratigraphic series simulation. On the basis of a recurrent neural network, a sequence model of the stratum type and a sequence model of the stratum thickness is successively established. The performance of the model is improved in combination with expert-driven learning. Finally, a machine learning model is established for a geostratigraphic series simulation, and a three-dimensional (3D) geological modeling evaluation method is proposed which considers the stratum type and thickness. The results show that we can use machine learning in the simulation of a series. The series model based on machine learning can describe the real situation at wells, and it is a complimentary tool to the traditional 3D geological model. The prediction ability of the model is improved to a certain extent by including expert-driven learning. This study provides a novel approach for the simulation and prediction of a series by 3D geological modeling.To understand the geological structure, many techniques and methods have been developed to describe, simulate, and model strata [1][2][3][4][5][6]. With the introduction of the Glass Earth [7] concept and geological data, interdisciplinary theoretical integration and application research is being carried out. The most representative traditional method of simulating the stratum structure is three-dimensional (3D) geological modeling, such as that with the B-rep model [8], octree model [9], tri-prism model [10] and geochron concepts [11][12][13][14]. However, the traditional method relies on the guidance of expert knowledge and experience in the selection of assumptions, parameters, and data interpolation methods, which are subjective and limited [15]. Assumptions about the borehole data distribution must be made, and it is difficult to effectively evaluate the stratum simulation results.Machine learning [16][17][18] has been widely used in various fields of geology. The machine learning method does not make too many assumptions about the data but selects a model according to the data characteristics. Then, the machine learning method divides the data into a training set and a test set and constantly adjusts the parameters to obtain better accuracy. Machine learning is more concerned with the predictive power of models [19]. In the fields of geology and engineering, there have been numerous research and application examples in different fields [20-25]. Rodriguez-Galiano et al. conducted a study on mineral exploration based on a decision tree [26]. Porwal et al. used radial function and neural network to evaluate potential maps in mineral exploration [27]. Zhang studied the relationships between ch...