2023
DOI: 10.3389/fcvm.2023.1129990
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3D histopathology of stenotic aortic valve cusps using ex vivo microfocus computed tomography

Abstract: BackgroundCalcific aortic stenosis (AS) is the most prevalent heart valve disease in developed countries. The aortic valve cusps progressively thicken and the valve does not open fully due to the presence of calcifications. In vivo imaging, usually used for diagnosis, does not allow the visualization of the microstructural changes associated with AS.MethodsEx vivo high-resolution microfocus computed tomography (microCT) was used to quantitatively describe the microstructure of calcified aortic valve cusps in f… Show more

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