2024
DOI: 10.1002/advs.202404064
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3D‐hUMSCs Exosomes Ameliorate Vitiligo by Simultaneously Potentiating Treg Cells‐Mediated Immunosuppression and Suppressing Oxidative Stress‐Induced Melanocyte Damage

Qi Wang,
Weinan Guo,
Liaoran Niu
et al.

Abstract: Vitiligo is an autoimmune disease characterized by epidermal melanocyte destruction, with abnormal autoimmune responses and excessive oxidative stress as two cardinal mechanisms. Human umbilical mesenchymal stem cells‐derived exosomes (hUMSCs‐Exos) are regarded as promising therapeutic choice for autoimmune diseases due to potent immunosuppressive and anti‐oxidative properties, which can be potentiated under 3D cell culture condition. Nevertheless, whether exosomes derived from 3D spheroids of hUMSCs (3D‐Exos)… Show more

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