The reduced modulus, E-R, of elastically anisotropic materials (Si, CaF2 and MgF2) was determined for sub-10 nm, several-10 nm and several-100 nm indentation depths, applying the Hertzian and Oliver-Pharr approaches. The E-R values determined for Si(100), Si(111), CaF2(100) and MgF2(100) deforming at sub-10 nm indentations (i.e. 135 GPa, 177 GPa, 142 GPa and 168 GPa) are in good agreement with the theoretical unidirectional E-R values (i.e. 125 GPa, 173 GPa, 135 GPa, 160 GPa). With increasing penetration depth up to several-10 nm, the E-R values gradually deviate from the unidirectional values to the weighted averaged values. E-R remains constant for sub-10 nm and several-10 nm penetration depths, performing the same indentation tests on amorphous organosilicate glass. The results of this study indicate that the modulus determined by nanoindentation depends on the size of indentation (ratio between contact radius and tip radius, a/R), especially in the case of elastically anisotropic materials. It is demonstrated for several-10 nm and several-100 nm penetration depth that the phase transformations in Si during the indentation tests strongly affect the E-R values