3D-Modeling of the Influence of Isomalt, Glucose, and Compaction Pressure on the Quality of Ascorbic-Acid Tablets

Filimonova, A. V.; Tret’yakova, Yu. A.; Gavrilov, A. S.

doi:10.1007/s11094-018-1841-2

Cited by 5 publications

(6 citation statements)

References 8 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We solved the crystal structure of II from PXRD data, and the slurry competition experiments were used to establish the thermodynamic relationship with I. The direct tableting of cocrystal polymorphs prepared in the solid-state was assessed to try to account for poor tableting properties of vitamin C. [51][52][53][54] 10 g scale by planetary ball milling. Planetary ball milling was performed by mixing 5.9 g of vitamin C and 4.1 g of nicotinamide in a 50 mL zirconia jar.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Control of Pharmaceutical Cocrystal Polymorphism on Various Scales by Mechanochemistry: Transfer from the Laboratory Batch to the Large-Scale Extrusion Processing

Stolar

Lukin

Tireli

et al. 2019

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

We demonstrate a controllable mechanochemical synthesis of cocrystal polymorphs of ascorbic acid (vitamin C) and nicotinamide (vitamin B3) on different scales and without using bulk solvents. Next to the previously described polymorph of the 1:1 cocrystal, which is one of the first cocrystals approved for human consumption, we report here a new, thermodynamically more stable polymorph detected during in situ synchrotron powder X-ray diffraction monitoring of milling reactions. The new polymorph is currently available exclusively by mechanochemical synthesis, and its crystal structure was determined from powder X-ray diffraction data. Laboratory in situ monitoring by Raman spectroscopy provided direct insight into the cocrystals formation and was further used to optimize the manufacturing procedure. Sub-gram synthesis using laboratory mixer mill was transferred to the 10 g scale on a planetary ball mill and continuous manufacturing using a twin-screw extruder. Both cocrystal polymorphs perform excellently in tableting, thus alleviating the notoriously poor compactible properties of vitamin C, while the mechanochemical cocrystallization does not harm its antioxidant properties. File list (3) download file view on ChemRxiv Stolar_manuscript_control of cocrystal polymorphism.pdf (1.52 MiB) download file view on ChemRxiv Stolar_SI_control of cocrystal polymorphism.pdf (814.41 KiB) download file view on ChemRxiv TOC.tif (115.72 KiB) Control of pharmaceutical cocrystal polymorphism on various scales by mechanochemistry: transfer from the laboratory batch-to the large-scale extrusion processing

show abstract

Section: Introductionmentioning

confidence: 99%

“…We solved the crystal structure of II from PXRD data and the slurry competition experiments were used to establish the thermodynamic relationship with I . The direct tableting of cocrystal polymorphs prepared in the solid-state was assessed to try to account for poor tableting properties of vitamin C. − …”

Section: Introductionmentioning

confidence: 99%

Control of Pharmaceutical Cocrystal Polymorphism on Various Scales by Mechanochemistry: Transfer from the Laboratory Batch to the Large-Scale Extrusion Processing

Stolar

Lukin

Tireli

et al. 2019

ACS Sustainable Chem. Eng.

View full text Add to dashboard Cite

show abstract

“…Hu et al [10] proposed a method based on machine learning and object recognition, which mapped the attitude estimation problem into a simpler pixel-by-pixel classification problem. Literature studies [11,12] simulate the stage visual lighting effect through OGRE rendering engine to achieve the effect of visual editing. Sutherland et al [13] simulated the stage scenery and designed the stage layout, lighting system arrangement, and other parts with mouse and keyboard, which saves manpower, material resources, and financial resources.…”

Section: Related Workmentioning

confidence: 99%

Design Mode of Stage Performing Arts Based on 3D Modeling and Moving Edge Computing Technology

Yuan

2022

Wireless Communications and Mobile Computing

View full text Add to dashboard Cite

In recent years, the virtual stage background has become increasingly popular in the stage design of large-scale art evenings as well as in dance performances. It deftly blends the form of dance beauty with the content of dance performance, creating an atmosphere that not only sets the scene but also expands the stage space and enhances the artistic expression of dance. This paper focuses on the design of stage performance art using 3D modeling and MEC (mobile edge computing) technology. The data fusion method of multi-Kinect joints is researched and realized using 3DMAX to complete the modeling and virtual design of a 3D virtual stage scene. The performance scheme is created by analyzing music features with a computer, designing lighting actions, and matching music and lighting actions. Finally, it shows how DDLS (distributed deep learning shunting) configuration affects convergence performance as well as how model setting affects the diversion scheme.

show abstract

Section: Introductionmentioning

confidence: 99%

Control of Pharmaceutical Cocrystal Polymorphism on Various Scales by Mechanochemistry: Transfer from the Laboratory Batch- to the Large-Scale Extrusion Processing

Stolar¹,

Lukin²,

Tireli³

et al. 2018

Preprint

View full text Add to dashboard Cite

<p>We demonstrate a controllable mechanochemical synthesis of cocrystal polymorphs of ascorbic acid (vitamin C) and nicotinamide (vitamin B3) on different scales and without using bulk solvents. Next to the previously described polymorph of the 1:1 cocrystal, which is one of the first cocrystals approved for human consumption, we report here a new, thermodynamically more stable polymorph detected during in situ synchrotron powder X-ray diffraction monitoring of milling reactions. The new polymorph is currently available exclusively by mechanochemical synthesis, and its crystal structure was determined from powder X-ray diffraction data. Laboratory in situ monitoring by Raman spectroscopy provided direct insight into the cocrystals formation and was further used to optimize the manufacturing procedure. Sub-gram synthesis using laboratory mixer mill was transferred to the 10 g scale on a planetary ball mill and continuous manufacturing using a twin-screw extruder. Both cocrystal polymorphs perform excellently in tableting, thus alleviating the notoriously poor compactible properties of vitamin C, while the mechanochemical cocrystallization does not harm its antioxidant properties.<b></b></p>

show abstract

3D-Modeling of the Influence of Isomalt, Glucose, and Compaction Pressure on the Quality of Ascorbic-Acid Tablets

Cited by 5 publications

References 8 publications

Control of Pharmaceutical Cocrystal Polymorphism on Various Scales by Mechanochemistry: Transfer from the Laboratory Batch to the Large-Scale Extrusion Processing

Control of Pharmaceutical Cocrystal Polymorphism on Various Scales by Mechanochemistry: Transfer from the Laboratory Batch to the Large-Scale Extrusion Processing

Design Mode of Stage Performing Arts Based on 3D Modeling and Moving Edge Computing Technology

Control of Pharmaceutical Cocrystal Polymorphism on Various Scales by Mechanochemistry: Transfer from the Laboratory Batch- to the Large-Scale Extrusion Processing

Contact Info

Product

Resources

About