3D Modeling Using the Finite Element Method for Directional Removal of a Cancerous Tumor

Mellal, Idir; Kengne, Emmanuel; Guemhioui, Karim El; Lakhssassi, Ahmed

doi:10.4172/2254-609x.100042

Cited by 4 publications

(8 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Next, the thermal damage of hepatic tissue for the multi-tine applicator and pre-defined limit values of electrode voltage was specified based on the Arrhenius model. Similar considerations can be found in several related papers concerning different kind of electric probes [16][17][18][19][20][21][22][23][24][25][26][27].…”

Section: Introductionsupporting

confidence: 76%

“…Importantly, the blood parameters are provided with subscript 'b', as in the case of ω b (1/s), which means the blood perfusion rate in liver tissue. Moreover, the term Q ext (W/m 3 ) denotes the Joule heating [12,16,18,26]:…”

Section: Model Definition and Governing Equationsmentioning

confidence: 99%

“…Initially, before the ablation procedure, the Ω-parameter has a zero value, but during the therapy, the Arrhenius integral value rises linearly in time or hyperbolically with temperature. It is worth noting that for Ω = 1 and Ω = 4.63 the probability of permanent cell destruction is, respectively, at a level of 63% and 99% [5,7,18,25].…”

Section: Arrhenius Thermal Damage Model Of Tissuementioning

confidence: 99%

See 2 more Smart Citations

Archives of Electrical Engineering

Gas,

Wyszkowska

2019

View full text Add to dashboard Cite

Percutaneous RF ablation is one of alternative treatment for non-surgical liver tumors. Ablative changes in hepatic tissue can be successfully estimated using the finite element method. The authors created a 3D model of a multi-tine applicator immersed in liver tissue, and then determined the optimal values of voltage applied to such an RF electrode, which do not exceed the therapeutic temperature range valid during thermal ablation procedure. Importantly, the simulations were carried out for the RF electric probes with 2 to 5 evenly spaced arms. Additionally, the thermal damage of hepatic tissue for multi-armed applicators working at pre-defined limit values of voltages was established based on the Arrhenius model.

show abstract

Section: Introductionsupporting

confidence: 76%

Section: Model Definition and Governing Equationsmentioning

confidence: 99%

Section: Arrhenius Thermal Damage Model Of Tissuementioning

confidence: 99%

See 1 more Smart Citation

Archives of Electrical Engineering

Gas,

Wyszkowska

2019

View full text Add to dashboard Cite

show abstract

“…They found that ablation volume increased with heating duration and power input, with the biggest ablation volume occurring with the maximum heating time and power input. A few researchers used timedependent input power to optimize the thermal damage for healthy cells [31,35]. Mellal et al [35] controlled the heat deposition and optimized the healthy cells damage by applying pulsating input power with a pulse on the duration of 2.5 s and a pulse off time of 5 s. Another crucial element in the microwave ablation procedure is the design of the antenna and the number of slots.…”

Section: Plos Onementioning

confidence: 99%

“…A few researchers used timedependent input power to optimize the thermal damage for healthy cells [31,35]. Mellal et al [35] controlled the heat deposition and optimized the healthy cells damage by applying pulsating input power with a pulse on the duration of 2.5 s and a pulse off time of 5 s. Another crucial element in the microwave ablation procedure is the design of the antenna and the number of slots. Ibitoye et al [32] examined the effectiveness of various MWA antenna proposals.…”

Section: Plos Onementioning

confidence: 99%

3D modeling of vector/edge finite element method for multi-ablation technique for large tumor-computational approach

Boregowda

Mariappan

2023

PLoS ONE

View full text Add to dashboard Cite

Microwave ablation (MWA) is a cancer thermal ablation treatment that uses electromagnetic waves to generate heat within the tissue. The goal of this treatment is to eliminate tumor cells while leaving healthy cells unharmed. During MWA, excess heat generation can kill healthy cells. Hence, mathematical models and numerical techniques are required to analyze the heat distribution in the tissue before the treatment. The aim of this research is to explain the implementation of the 3D vector finite element method in a wave propagation model that simulates the specific absorption rate in the liver. The 3D Nedelec elements from H(curl; Ω) space are used to discretize the wave propagation model, and this implementation is helpful in solving many real-world problems that involve electromagnetic propagation with perfect conducting and absorbing boundary conditions. One of the difficulties in ablation treatment is creating a large ablation zone for a large tumor (diameter greater than 3 cm) in a short period of time with minimum damage to the surrounding tissue. This article addresses the aforementioned issue by introducing four antennas into the different places of the tumor sequentially and producing heat uniformly over the tumor. The results demonstrated that 95.5% of the tumor cells were killed with minimal damage to the healthy cells when the heating time was increased to 4 minutes at each position. Subsequently, we studied the temperature distribution and localised tissue contraction in the tissue using the three-dimensional bio-heat equation and temperature-time dependent model, respectively. The local tissue contraction is measured at arbitrary points in the domain and is more noticeable at temperatures higher than 102°C. The thermal damage in the liver during MWA treatment is investigated using the three-state cell death model. The system of partial differential equations is solved numerically due to the complex geometry of the domain, and the results are compared with experimental data to validate the models and parameters.

show abstract