3D multiphasic porous scaffolds of calcium phosphates doping with silicon and magnesium

This work proposes the use of multilayer scaffolds as a strategy for developing biomimetic structures for bone tissue regeneration. The scaffolds consist of a glass–ceramic core composed of CaSiO3/Ca2P6O17, which provides mechanical properties of 2.3 MPa and a total porosity of ∼74%. To modify the surface morphology a double bioactive coating consisting of Ca3(PO4)2/CaSiO3 doped with Na+ and K+, along with varying amounts of Mg2+ (0–0.75 g MgCO3) was carried out giving a total porosity of 89.8%. The resulting scaffolds were assessed for in vitro bioactivity according to ISO 23317. After immersion in SBF, the W‐05 scaffolds displayed diverse surface morphologies: square HA structure (W‐05‐3D), hollow HA spheres (W‐05‐7D) and smooth HA layer (W‐05‐21D). Cell viability of 3T3 fibroblasts exposed to W‐05 scaffolds in direct and indirect assays at concentrations of 15 and 30 mg/mL was assessed according to ISO 10993–5. Initially, cell proliferation decreased compared to controls, but differences became non‐statistically significant after 72 h. Hollow spheres (W‐05‐7D) enhanced cell viability compared to other morphologies and plastic controls. Additionally, degradation products of W‐05 stimulated cell division, underscoring scaffold biocompatibility.

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Effect Investigation of Ammonium Bicarbonate and Polyethylene Wax as Pore-Forming Agents on the Physicochemical Properties of Macroporous Biphasic Calcium Phosphate Bioceramics Processed by Space-Holder Technique

Ribeiro,

Balbuena,

Lima

et al. 2024

Mat. Res.

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3D multiphasic porous scaffolds of calcium phosphates doping with silicon and magnesium

Cited by 3 publications

References 25 publications

Sol-gel derived silicate-phosphate glass SiO2–P2O5–CaO–TiO2: The effect of titanium isopropoxide on porosity and thermomechanical stability

Sol-gel derived silicate-phosphate glass SiO2–P2O5–CaO–TiO2: The effect of titanium isopropoxide on porosity and thermomechanical stability

Surface morphology modulation in multilayer scaffolds via ion doping for bone tissue engineering

Effect Investigation of Ammonium Bicarbonate and Polyethylene Wax as Pore-Forming Agents on the Physicochemical Properties of Macroporous Biphasic Calcium Phosphate Bioceramics Processed by Space-Holder Technique

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