3D pCASL-perfusion in preoperative assessment of brain gliomas in large cohort of patients

Баталов, А И; Захарова, Н. Е.; Pronin, Igor; Belyaev, A. Yu.; Pogosbekyan, E L; Goryaynov, S A; Bykanov, Andrey; Tyurina, A. N.; Шевченко, А. М.; Соложенцева, К. Д.; Никитин, П.В.; Потапов, А А

doi:10.1038/s41598-022-05992-4

Cited by 9 publications

(6 citation statements)

References 33 publications

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“…Meta-analysis studies indicated the usefulness of ASL imaging for grading gliomas [ 14 , 15 ]. Batalov et al [ 20 ] analyzed 253 patients with gliomas who underwent ASL imaging with a PLD of 1525 ms. They demonstrated higher tumor blood flow in high-grade gliomas than in low-grade gliomas.…”

Section: Discussionmentioning

confidence: 99%

“…The PLD should be selected based on the balance between arrival into the tissues and preservation of magnetic labeling. The PLD values described in the previous studies, including the brain tumor studies mentioned above [ 17 , 20 , 21 ], were in the range of 1.5 s to 2 s. A consensus statement recommended 2000 ms for adult clinical patients, considering possible prolongation of the ATT under pathological conditions [ 2 ].…”

Section: Discussionmentioning

confidence: 99%

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Effects of Post-Labeling Delay on Magnetic Resonance Evaluation of Brain Tumor Blood Flow Using Arterial Spin Labeling

et al. 2023

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We investigated the effect of post-labeling delay (PLD) on the evaluation of brain tumor blood flow using arterial spin labeling (ASL) magnetic resonance (MR) imaging to assess the need for imaging with two PLDs. Retrospective analysis was conducted on 63 adult patients with brain tumors who underwent contrast-enhanced MR imaging including ASL imaging with PLDs of both 1525 and 2525 ms on a 1.5 T or 3 T MR unit. Blood flow was estimated in the tumors and normal-appearing brain parenchyma, and tumor blood flow was normalized by parenchymal flow. Estimates of tumor blood flow, parenchymal flow, and normalized tumor flow showed no statistically significant differences between PLDs of 1525 and 2525 ms. Close correlations between different PLDs were found, with the closest correlation for normalized tumor flow. These results were similarly observed for the 1.5 T and 3 T units. The blood flow estimates obtained using ASL MR imaging in patients with brain tumors were highly concordant between PLDs of 1525 and 2525 ms, irrespective of the magnetic field strength. It is indicated that imaging with a single, standard PLD is acceptable for ASL assessment of brain tumor perfusion and that additional imaging with a long PLD is not required.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Effects of Post-Labeling Delay on Magnetic Resonance Evaluation of Brain Tumor Blood Flow Using Arterial Spin Labeling

et al. 2023

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“…In the present study we focused on the the predictive value of maximum rather than mean TBF, as we have previously showed that maximum TBF is more informativa for glioma diagnosis than mean TBF [ 20 ].…”

Section: Methodsmentioning

confidence: 99%

“…The latter method seems to be balanced in quality and clinical applicability. There are some positive results concerning ASL in glioma grading [ 20 , 21 ].…”

Section: Introductionmentioning

confidence: 99%

Arterial Spin Labeling Perfusion in Determining the IDH1 Status and Ki-67 Index in Brain Gliomas

et al. 2022

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The aim of the study was to evaluate the relationship between tumor blood flow (TBF) measured by the pseudo-continuous arterial spin labeling (PCASL) method and IDH1 mutation status of gliomas as well as Ki-67 proliferative index. Methods. The study included 116 patients with newly diagnosed gliomas of various grades. They received no chemotherapy or radiotherapy before MRI. IDH1 status assessment was performed after tumor removal in 106 cases—48 patients were diagnosed with wildtype gliomas (Grade 1–2—6 patients, Grade 3–4—42 patients) and 58 patients were diagnosed with mutant forms of gliomas (Grade 1–2—28 patients, Grade 3–4—30 patients). In 64 cases out of 116 Ki-67 index was measured. Absolute and normalized tumor blood flow values were measured on 3D PCASL maps. Results. TBF and normalized TBF (nTBF) in wildtype gliomas were significantly higher than in IDH1-mutant gliomas (p < 0.001). ASL perfusion showed high values of sensitivity and specificity in the differential diagnosis of gliomas with distinct IDH1 status (for TBF: specificity 75%, sensitivity 77.6%, AUC 0.783, cutoff 80.57 mL/100 g/min, for nTBF: specificity 77.1%, sensitivity 79.3%, AUC 0.791, cutoff 4.7). TBF and nTBF in wildtype high-grade gliomas (HGG) were significantly higher than in mutant forms (p < 0.001). ASL perfusion showed the following values of sensitivity and specificity in the diagnosis of mutant HGG and wildtype HGG (for TBF: specificity 83.3%, sensitivity 60%, AUC 0.719, cutoff 84.18 mL/100 g/min, for nTBF: specificity 88.1%, sensitivity 60%, AUC 0.729, cutoff 4.7). There was a significant positive correlation between tumor blood flow and Ki-67 (for TBF Rs = 0.63, for nTBF Rs = 0.61). Conclusion. ASL perfusion may be an informative factor in determining the IDH1 status in brain gliomas preoperative and tumor proliferative activity.

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“…Elevation of cerebral blood flow (CBF) on CT-and MR-perfusion images is a consequence of tumor-induced neoangiogenesis. Previously, pseudo-continuous arterial spin labeling (pCASL) showed the capability to differentiate high-and low-grade gliomas [9,10]. Perfusion methods were used to study peritumoral edema [11] as well as being successfully employed to differentiate glioblastomas and metastases or glioblastomas and lymphomas [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Perifocal Zone of Brain Gliomas: Application of Diffusion Kurtosis and Perfusion MRI Values for Tumor Invasion Border Determination

Захарова

Баталов

Pogosbekyan

et al. 2023

Cancers

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(1) Purpose: To determine the borders of malignant gliomas with diffusion kurtosis and perfusion MRI biomarkers. (2) Methods: In 50 high-grade glioma patients, diffusion kurtosis and pseudo-continuous arterial spin labeling (pCASL) cerebral blood flow (CBF) values were determined in contrast-enhancing area, in perifocal infiltrative edema zone, in the normal-appearing peritumoral white matter of the affected cerebral hemisphere, and in the unaffected contralateral hemisphere. Neuronavigation-guided biopsy was performed from all affected hemisphere regions. (3) Results: We showed significant differences between the DKI values in normal-appearing peritumoral white matter and unaffected contralateral hemisphere white matter. We also established significant (p < 0.05) correlations of DKI with Ki-67 labeling index and Bcl-2 expression activity in highly perfused enhancing tumor core and in perifocal infiltrative edema zone. CBF correlated with Ki-67 LI in highly perfused enhancing tumor core. One hundred percent of perifocal infiltrative edema tissue samples contained tumor cells. All glioblastoma samples expressed CD133. In the glioblastoma group, several normal-appearing white matter specimens were infiltrated by tumor cells and expressed CD133. (4) Conclusions: DKI parameters reveal changes in brain microstructure invisible on conventional MRI, e.g., possible infiltration of normal-appearing peritumoral white matter by glioma cells. Our results may be useful for plotting individual tumor invasion maps for brain glioma surgery or radiotherapy planning.

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3D pCASL-perfusion in preoperative assessment of brain gliomas in large cohort of patients

Cited by 9 publications

References 33 publications

Effects of Post-Labeling Delay on Magnetic Resonance Evaluation of Brain Tumor Blood Flow Using Arterial Spin Labeling

Effects of Post-Labeling Delay on Magnetic Resonance Evaluation of Brain Tumor Blood Flow Using Arterial Spin Labeling

Arterial Spin Labeling Perfusion in Determining the IDH1 Status and Ki-67 Index in Brain Gliomas

Perifocal Zone of Brain Gliomas: Application of Diffusion Kurtosis and Perfusion MRI Values for Tumor Invasion Border Determination

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