3D-poly (lactic acid) scaffolds coated with gelatin and mucic acid for bone tissue engineering

Ashwin, Badrinath; Abinaya, Balakrishnan; Prasith, Tandiakkal Prakash; Chandran, S. Viji; Yadav, L. Roshini; Vairamani, M.; Patil, Shantanu; Selvamurugan, N.

doi:10.1016/j.ijbiomac.2020.06.157

Cited by 74 publications

(41 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In another study, albumin coating on Ti material contributed to increased osteoblast viability [76]. Whereas 3D-polylactic acid (PLA) scaffold coated with gelatin and mucic acid supported cell adhesion, promoted osteogenic differentiation of murine embryonic fibroblast cell line (C3H10T1/2 cell line), and ECM mineralization, as shown by Ashwin et al [77]. Liu et al [74] covered porous β-Ca 3 (PO 4 ) 2 /Mg-Zn (β-TCP/Mg-Zn) composites with dopamine/gelatin/recombinant human BMP-2 coating.…”

Section: Inorganic and Composite Coatingsmentioning

confidence: 82%

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Kazimierczak

Przekora

2020

Coatings

View full text Add to dashboard Cite

The main aim of bone tissue engineering is to fabricate highly biocompatible, osteoconductive and/or osteoinductive biomaterials for tissue regeneration. Bone implants should support bone growth at the implantation site via promotion of osteoblast adhesion, proliferation, and formation of bone extracellular matrix. Moreover, a very desired feature of biomaterials for clinical applications is their osteoinductivity, which means the ability of the material to induce osteogenic differentiation of mesenchymal stem cells toward bone-building cells (osteoblasts). Nevertheless, the development of completely biocompatible biomaterials with appropriate physicochemical and mechanical properties poses a great challenge for the researchers. Thus, the current trend in the engineering of biomaterials focuses on the surface modifications to improve biological properties of bone implants. This review presents the most recent findings concerning surface modifications of biomaterials to improve their osteoconductivity and osteoinductivity. The article describes two types of surface modifications: (1) Additive and (2) subtractive, indicating biological effects of the resultant surfaces in vitro and/or in vivo. The review article summarizes known additive modifications, such as plasma treatment, magnetron sputtering, and preparation of inorganic, organic, and composite coatings on the implants. It also presents some common subtractive processes applied for surface modifications of the biomaterials (i.e., acid etching, sand blasting, grit blasting, sand-blasted large-grit acid etched (SLA), anodizing, and laser methods). In summary, the article is an excellent compendium on the surface modifications and development of advanced osteoconductive and/or osteoinductive coatings on biomaterials for bone regeneration.

show abstract

Section: Inorganic and Composite Coatingsmentioning

confidence: 82%

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Kazimierczak

Przekora

2020

Coatings

View full text Add to dashboard Cite

show abstract

“…3D printing and bioprinting have extensive uses in the field of complex formation through colloidal self-assemblies [22], tissue or bone regeneration [23][24][25][26][27], neuroblastoma cell culture systems [28], fabrication of nerve conduit or implant engineering [29][30][31], alignment of muscle cells [32], in vaccine delivery [33], molecular diagnostics [34], etc. 3DBP technology holds a great potential for gene delivery into the defective cells for various diseases, in tissue engineering and regeneration medicine and especially in treating bone defects, wherein the specific nucleic acid is precisely placed into the 3D printed tissue, organ or a scaffold (bone or muscle implants) for treatment.…”

Section: Applications Of 3dp For Genetic Modulationmentioning

confidence: 99%

3D Printed Bioconstructs: Regenerative Modulation for Genetic Expression

Shende

Trivedi

2021

Stem Cell Rev and Rep

View full text Add to dashboard Cite

Layer-by-layer deposition of cells, tissues and similar molecules provided by additive manufacturing techniques such as 3D bioprinting offers safe, biocompatible, effective and inert methods for the production of biological structures and biomimetic scaffolds. 3D bioprinting assisted through computer programmes and software develops mutli-modal nano-or micro-particulate systems such as biosensors, dosage forms or delivery systems and other biological scaffolds like pharmaceutical implants, prosthetics, etc. This review article focuses on the implementation of 3D bioprinting techniques in the gene expression, in gene editing or therapy and in delivery of genes. The applications of 3D printing are extensive and include gene therapy, modulation and expression in cancers, tissue engineering, osteogenesis, skin and vascular regeneration. Inclusion of nanotechnology with genomic bioprinting parameters such as gene conjugated or gene encapsulated 3D printed nanostructures may offer new avenues in the future for efficient and controlled treatment and help in overcoming the limitations faced in conventional methods. Moreover, expansion of the benefits from such techniques is advantageous in real-time delivery or in-situ production of nucleic acids into the host cells.

show abstract

“…3D bioprinting is currently widely applied in the fields of tissue or bone regeneration (20,21), neuroblastoma cell culture systems (22), neural catheters or implant engineering (23), vaccine delivery (24), molecular diagnosis (25), surgical models (26), and other fields. In addition, 3D bioprinting technology exhibits significant potential for delivering genes to defective cells in tissue engineering, regenerative medicine, and treating various diseases, especially bone defects (27).…”

Section: The Application Of Gene Modification Based On 3d Bioprintingmentioning

confidence: 99%

Narrative review of gene modification: applications in three-dimensional (3D) bioprinting

Fu¹,

Shen²,

Chen³

et al. 2021

Ann Transl Med

View full text Add to dashboard Cite

Objective: This article focused on the application scenarios of three-dimensional (3D) bioprinting and gene-editing technology in various medical fields, including gene therapy, tissue engineering, tumor microenvironment simulation, tumor model construction, cancer regulation and expression, osteogenesis, and skin and vascular regeneration, and summarizing its development prospects and shortcomings.Background: 3D bioprinting is a process based on additive manufacturing that uses biological materials as the microenvironment living cells. The scaffolds and carriers manufactured by 3D bioprinting technology provide a safe, efficient, and economical platform for genes, cells, and biomolecules. Gene modification refers to replacing, splicing, silencing, editing, controlling or inactivating genes and delivering new genes.The combination of this technology that changes cell function or cell fate or corrects endogenous mutations and 3D bioprinting technology has been widely used in various medical field.Methods: We conducted a literature search for papers published up to March 2021 on the gene modification combined with 3D bioprinting in various medical fields via PubMed, Web of Science, China National Knowledge Infrastructure (CNKI). The following medical subject heading terms were included for a MEDLINE search: "3D printing/gene editing", "3D printing/genetic modification", "3D printing/seed cell", "bioprinting/gene editing", "bioprinting/genetic modification", "bioprinting/seed cell", "scaffold/gene editing", "scaffold/genetic modification", "scaffold/seed cell", "gene/scaffold", "gene/bioprinting", "gene/3D printing". Quantitative and qualitative data was extracted through interpretation of each article. Conclusions:We have reviewed the application scenarios of 3D bioprinting and gene-editing technology in various medical fields, it provides an efficient and accurate delivery system for personalized tumor therapy, enhancing the targeting effect while maintaining the integrity of the fabricated structure. It exhibits significant application potential in developing tumor drugs. In addition, scaffolds obtained via 3D bioprinting provide gene therapy applications for skin and bone healing and repair and inducing stem cell differentiation.It also considers the future development direction in this field, such as the emergence and development of

show abstract

3D-poly (lactic acid) scaffolds coated with gelatin and mucic acid for bone tissue engineering

Cited by 74 publications

References 61 publications

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

Osteoconductive and Osteoinductive Surface Modifications of Biomaterials for Bone Regeneration: A Concise Review

3D Printed Bioconstructs: Regenerative Modulation for Genetic Expression

Narrative review of gene modification: applications in three-dimensional (3D) bioprinting

Contact Info

Product

Resources

About