3D pore-interconnected calcium phosphate bone blocks for bone tissue engineering

Pandey, Aditi; Kuo, Chen–Lung; Liang, Chao-Chun; Chang, Liang Yu; Hsu, Chieh Yun; Lee, Sheng Yang; Teng, Nai Chia; Yang, Jen Chang

doi:10.1016/j.ceramint.2020.03.211

Cited by 6 publications

(3 citation statements)

References 38 publications

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“…However, a pore size of 300 μm or more is recommended due to the accelerated formation of new bone and the formation of new blood capillaries 21) . Pandey et al 8) investigated in vitro cell cultures of four porous calcium phosphate samples with average pore diameters of 106 μm, 235 μm, 460 μm and 1123 μm. The results showed that osteoblast survival and adhesion were enhanced in osteoblast (MC3T3-E1) culture in the 235 μm and 460 μm samples, while adhesion was hardly enhanced in the 106 μm and 1123 μm average pore size samples.…”

Section: Effect Of the Coating Amountmentioning

confidence: 99%

“…[4][5][6] The blood vessels in bone are important for providing osteocyte activity and for promoting bone remodeling because they transport nutrients and waste products necessary for the maintenance of biological tissues and for cell migration. 7,8) The mechanical strength of porous materials decreases as their porosity increases. Therefore, it is important to develop bone replacement materials that provide both the mechanical strength necessary to act as scaffolds and the porosity needed for cell biocompatibility and tissue regeneration.…”

Section: Introductionmentioning

confidence: 99%

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FABRICATION OF POROUS Β-Tricalcium PHOSPHATE SCAFFOLDS USING FOAM REPLICA WITH 3D TECHNOLOGY

Tsuchiya

Shohei

Ohno

et al. 2021

Phosphorus Research Bulletin

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The present work is based on prior research into the synthesis of porous β-tricalcium phosphate (β-TCP) with continuous pores by applying a β-TCP suspension onto a porous polyurethane foam by spray coating followed by pyrolysis of the foam. In the work reported herein, the three-dimensional (3D) pore structure of a polyurethane foam specimen was scanned using X-ray computerized tomography after which a porous acrylic foam with an optimized pore structure was fabricated using a 3D printer based on this scan. The pore size and pillar diameter of the porous printed material could be modified simply by changing the brightness value of the image data in the processing software. Specifically, the pillar diameter was increased while the pore size became smaller as the brightness was increased. β-TCP with interconnecting pores could be easily fabricated by spray coating these printed molds. The physical properties and porous structure of the product could also be tuned by modifying the pore structure of the foam and the amount of spray coating. The porous β-TCP obtained in this study had sufficient physical properties to be used as a scaffold material, suggesting the possibility of applying this scanning process to other porous materials, including living bones.

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Section: Effect Of the Coating Amountmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

FABRICATION OF POROUS Β-Tricalcium PHOSPHATE SCAFFOLDS USING FOAM REPLICA WITH 3D TECHNOLOGY

Tsuchiya

Shohei

Ohno

et al. 2021

Phosphorus Research Bulletin

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show abstract

“…HPMC and glycerin are used as plasticizers in injectable or putty forms in commercially available bone substitutes [26][27][28][29]. Because of its biocompatibility [30], degradability [31], and non-toxic properties, HPMC has been used as a scaffold material in bone tissue engineering [32,33]. In addition, HPMC increases osteogenesis [34,35] and does not affect the degradation time [36].…”

Section: Introductionmentioning

confidence: 99%

Improved Anti-Washout Property of Calcium Sulfate/Tri-Calcium Phosphate Premixed Bone Substitute with Glycerin and Hydroxypropyl Methylcellulose

Chiang

Hsu

et al. 2021

Applied Sciences

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Calcium sulfate/calcium phosphate (CS-CP)-based bone substitutes have been developed in premixed putty for usage in clinical applications. However, it is difficult to completely stop the bleeding during an operation because premixed putty can come into contact with blood or body fluids leading to disintegration. Under certain conditions depending on particle size and morphology, collapsed (washed) particles can cause inflammation and delay bone healing. In this context, anti-washout premixed putty CS-CP was prepared by mixing glycerin with 1, 2, and 4 wt% of hydroxypropyl methylcellulose (HPMC), and the resultant anti-washout properties were evaluated. The results showed that more than 70% of the premixed putty without HPMC was disintegrated after being immersed into simulated body fluid (SBF) for 15 min. The results demonstrated that the more HPMC was contained in the premixed putty, the less disintegration occurred. We conclude that CS-CP pre-mixed putty with glycerin and HPMC is a potential bone substitute that has good anti-washout properties for clinical applications.

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Tissue Engineering Applications of Marine-Based Materials

Polat¹,

Zeybek²,

Polat³

2022

Marine Biomaterials

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3D pore-interconnected calcium phosphate bone blocks for bone tissue engineering

Cited by 6 publications

References 38 publications

FABRICATION OF POROUS Β-Tricalcium PHOSPHATE SCAFFOLDS USING FOAM REPLICA WITH 3D TECHNOLOGY

FABRICATION OF POROUS Β-Tricalcium PHOSPHATE SCAFFOLDS USING FOAM REPLICA WITH 3D TECHNOLOGY

Improved Anti-Washout Property of Calcium Sulfate/Tri-Calcium Phosphate Premixed Bone Substitute with Glycerin and Hydroxypropyl Methylcellulose

Tissue Engineering Applications of Marine-Based Materials

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