3D Porous Crystalline Polyimide Covalent Organic Frameworks for Drug Delivery

Abstract

Three-dimensional porous crystalline polyimide covalent organic frameworks (termed PI-COFs) have been synthesized. These PI-COFs feature non- or interpenetrated structures that can be obtained by choosing tetrahedral building units of different sizes. Both PI-COFs show high thermal stability (>450 °C) and surface area (up to 2403 m(2) g(-1)). They also show high loading and good release control for drug delivery applications.

Porous organic polymer bifunctionalized with triazine and thiophene groups as a novel adsorbent for removing Cu (II)

“…[21][22][23] Owing to their high surface areas, well-defined porosities and variety of structures, POPs have attracted great attention with diverse applications. [24][25][26] By incorporating multiple chemical functionalities into the porous networks, POPs can be designed and constructed as task-specific materials with versatile applications. Recently, a sulfonic acid-modified microporous hyper-crosslinked polymer (SAM-HCP) has been investigated as an adsorbent for Cu (II) removal from water.…”

Selective Molecular Sieving in Self‐Standing Porous Covalent‐Organic‐Framework Membranes

“…[18] Fabrication of these membranes is done using various techniques such as plasma polymerization, [18b] interfacial polymerizations [18a] and spin coating. [1][2][3][4] Even though COFs have been dem onstrated for storage applications of a wide variety of molecular species like gasses, [5] nanoparticles, [6] enzymes [7] and drugs; [8] benefits of their ordered pore channels for molecular separation is hardly extracted. Apart from traditional polymeric membranes, a handful of porous crystalline materials such as zeolites [19] and metal-organic frameworks (MOFs) [20] have shown potential for molecular separation through preferential adsorption in ordered pore channels.…”

“…This approach is very simple (like making cakes and biscuits), which is easily processable (thus scalable) and could be highly cost effective. [1][2][3][4] Even though COFs have been dem onstrated for storage applications of a wide variety of molecular species like gasses, [5] nanoparticles, [6] enzymes [7] and drugs; [8] benefits of their ordered pore channels for molecular separation is hardly extracted. [21] These selfstanding COMs are flexible, continuous, devoid of Covalent organic frameworks (COFs) represent a new category of highly porous, crystalline polymers with uniformly arranged ordered pore channels.…”

Moving Beyond Boron: The Emergence of New Linkage Chemistries in Covalent Organic Frameworks

“…Rhodamine B's luminescence intensity is inversely proportional to temperature, making the COFs interesting for optical temperature sensing. More recently, the Yan group extended this work to a three-dimensional polyimide COF that released ibuprofen over 7 days instead of the typical biological half-life of 2 h. 76 …”