3D porous poly(ε-caprolactone)/58S bioactive glass–sodium alginate/gelatin hybrid scaffolds prepared by a modified melt molding method for bone tissue engineering

Mao, Daoyong; Li, Qing; Li, Daikun; Tan, Yen Kheng; Che, Qijun

doi:10.1016/j.matdes.2018.08.062

Cited by 58 publications

(25 citation statements)

References 41 publications

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“…A myriad of techniques are available to fabricate scaffolds including solvent casting 5 , freeze casting 6 , freeze drying 7 , electrospinning 8 , gas foaming 9 , particulate-leaching 10 , melt molding 11 , phase separation 12 , and self-assembly 13 and sol–gel methods 14 . However, most techniques are limited by their poor control over scaffold design, architecture, pore network and pore size.…”

Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds

Seyedsalehi

Daneshmandi

Barajaa

et al. 2020

Sci Rep

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The ability to produce constructs with a high control over the bulk geometry and internal architecture has situated 3D printing as an attractive fabrication technique for scaffolds. Various designs and inks are actively investigated to prepare scaffolds for different tissues. In this work, we prepared 3D printed composite scaffolds comprising polycaprolactone (PCL) and various amounts of reduced graphene oxide (rGO) at 0.5, 1, and 3 wt.%. We employed a two-step fabrication process to ensure an even mixture and distribution of the rGO sheets within the PCL matrix. The inks were prepared by creating composite PCL-rGO films through solvent evaporation casting that were subsequently fed into the 3D printer for extrusion. The resultant scaffolds were seamlessly integrated, and 3D printed with high fidelity and consistency across all groups. This, together with the homogeneous dispersion of the rGO sheets within the polymer matrix, significantly improved the compressive strength and stiffness by 185% and 150%, respectively, at 0.5 wt.% rGO inclusion. The in vitro response of the scaffolds was assessed using human adipose-derived stem cells. All scaffolds were cytocompatible and supported cell growth and viability. These mechanically reinforced and biologically compatible 3D printed PCL-rGO scaffolds are a promising platform for regenerative engineering applications.

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Section: Introductionmentioning

confidence: 99%

Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds

Seyedsalehi

Daneshmandi

Barajaa

et al. 2020

Sci Rep

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show abstract

“…Results Reference polycaprolactone-58S bioactive glasssodium/alginate-gelatin enhanced mechanical properties, hydrophilicity, and biodegradability (Mao et al, 2018) alginate/gelatin bioinks with an apatite increased Young's modulus, protein adsorption, and enhanced (Luo et al, 2018) layer rBMSCs adhesion, proliferation, and osteogenic differentiation gelatin-CMC-hydroxyapatite enhanced proliferation and differentiation of human Wharton's jelly MSC microtissue/slower degradation (Maji et al, 2018) Vitamin D3 encapsulated in gelatin/layered double hydroxides-hydroxyapatite high density and Young's modulus and: enhanced cell viability and proliferation for G-292 cells (Fayyazbakhsh et al, 2017).…”

Section: Gelatin-based Biomaterialsmentioning

confidence: 97%

“…The presence of this microspheres in the pores was confirmed by SEM images. Furthermore, the use of 58S bioactive glass-sodium enhanced the mechanical properties, the hydrophilicity, and the biodegradability of the scaffolds (Mao et al, 2018). As mentioned above, alginate is another natural polymer which is currently studied for BTE applications.…”

Section: New Approaches For Gelatin-based Biomaterialsmentioning

confidence: 99%

A review of chitosan-, alginate-, and gelatin-based biocomposites for bone tissue engineering

2018

Biomater Tissue Eng Bull

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Bone diseases and injuries have a major impact on the quality of life. Classical treatments for bone repair/regeneration/replacement have various disadvantages. Bone tissue engineering (BTE) received a great attention in the last years. Natural polymers are intensively studied in this field due to their properties (biocompatibility, biodegradability, abundance in nature, high processability). Unfortunately, their mechanical properties are poor, which is why synthetic polymers or ceramics are added in order to provide the optimal compressive, elastic or fatigue strength. Moreover, growth factors, vitamins, or antimicrobial substances are also added to enhance the cell behavior (attachment, proliferation, and differentiation). In this review, new scientific results regarding potential applications of chitosan-, alginate-, and gelatin based biocomposites in BTE will be provided, along with their in vitro and/or in vivo tests.

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“…Hydrogels are made by techniques such as solvent casting/particulate leaching [ 138 ], gas foaming [ 139 ], phase separation [ 140 ], melt molding [ 141 ], and freeze-drying [ 142 ] ( Figure 6 ). Hydrogels can be manufactured as films, coatings, nanoparticles, etc., and can act as semipermeable membranes through which fluid can flow in three dimensions.…”

Section: Various Strategies Of Anti-adhesionmentioning

confidence: 99%

“… Hydrogel fabrication techniques: ( a ) Solvent-casting/particulate-leaching [ 138 ]; ( b ) gas foaming [ 139 ]; ( c ) phase separation [ 140 ]; ( d ) melt molding [ 141 ]; and ( e ) freeze drying [ 142 ] (images adopted with permission). …”

Section: Figurementioning

confidence: 99%

Biomaterials to Prevent Post-Operative Adhesion

et al. 2020

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Surgery is performed to treat various diseases. During the process, the surgical site is healed through self-healing after surgery. Post-operative or tissue adhesion caused by unnecessary contact with the surgical site occurs during the normal healing process. In addition, it has been frequently found in patients who have undergone surgery, and severe adhesion can cause chronic pain and various complications. Therefore, anti-adhesion barriers have been developed using multiple biomaterials to prevent post-operative adhesion. Typically, anti-adhesion barriers are manufactured and sold in numerous forms, such as gels, solutions, and films, but there are no products that can completely prevent post-operative adhesion. These products are generally applied over the surgical site to physically block adhesion to other sites (organs). Many studies have recently been conducted to increase the anti-adhesion effects through various strategies. This article reviews recent research trends in anti-adhesion barriers.

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3D porous poly(ε-caprolactone)/58S bioactive glass–sodium alginate/gelatin hybrid scaffolds prepared by a modified melt molding method for bone tissue engineering

Cited by 58 publications

References 41 publications

Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds

Fabrication and characterization of mechanically competent 3D printed polycaprolactone-reduced graphene oxide scaffolds

A review of chitosan-, alginate-, and gelatin-based biocomposites for bone tissue engineering

Biomaterials to Prevent Post-Operative Adhesion

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