3D printable SiO<sub>2</sub> nanoparticle ink for patient specific bone regeneration

Roopavath, Uday Kiran; Soni, Raghav; Mahanta, Urbashi; Deshpande, Atul Suresh; Rath, Subha Narayan

doi:10.1039/c9ra03641e

Cited by 59 publications

(40 citation statements)

References 45 publications

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“…Recently, SiO 2 nanoparticles were loaded into alginate-gelatin composite hydrogels chemically crosslinked with CaCl 2 solution for the printing of an irregular specific defect using a BIOBOT (Allevi) 3D printer (Roopavath, Soni, Mahanta, Deshpande, & Rath, 2019). The effect of SiO 2 nanoparticles on the viscosity, degradation, compressive modulus (MPa), biocompatibility and osteogenic ability post-seeding were evaluated on lyophilized scaffolds.…”

Section: D-printing Of Alginate Hydrogel-ceramic Composites For Bone Engineeringmentioning

confidence: 99%

Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review

Hernández-González

Téllez-Jurado

Rodríguez‐Lorenzo

2020

Carbohydrate Polymers

405

209

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This review focuses on recently developed alginate injectable hydrogels and alginate composites for applications in bone tissue regeneration, and it evaluates the alternatives to overcome the problems that avoid their utilization in the field. Section 2 covers the properties of alginates that have made them useful for medical applications, in particular their ionic gelling ability for preparing injectable compositions used as delivery drugs systems. The advantages and shortcomings of these preparations are revised together with the chemical modifications assayed. Section 3 describes how it has been taken advantage of alginates into the new field of biofabrication and the developments in bone engineering. The state of the art of this field is reviewed. Finally in Section 4, new developments and approaches that in opinion of the authors can lead to a breakthrough in bone tissue engineering using alginates are introduced.

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Section: D-printing Of Alginate Hydrogel-ceramic Composites For Bone Engineeringmentioning

confidence: 99%

Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review

Hernández-González

Téllez-Jurado

Rodríguez‐Lorenzo

2020

Carbohydrate Polymers

405

209

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“…This ink concentration demonstrated an enhanced osteogenic ability and better cell proliferation effects compared with the other levels. [ 123,124 ]…”

Section: D Printing and Nanotechnology Alliancementioning

confidence: 99%

3D Printing and Nanotechnology: A Multiscale Alliance in Personalized Medicine

Santos

Oliveira

et al. 2021

Adv Funct Materials

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3D printing and nanotechnology have been two important tools in the development of therapeutic approaches for personalized medicine. More recently, their alliance has been improved in an effort to build innovative, versatile, multifunctional, and/or smart medical and pharmaceutical products. Therefore, an extensive review about scientific studies that ally 3D printing and nanomaterials in the development of new approaches for pharmaceutical and medical applications for the treatment and prevention of diseases is presented here. The articles are classified into five categories according to their main application: Cell growth and tissue engineering, antimicrobial, drug delivery, stimulus‐response, and theranostics. Semisolid extrusion, inorganic nanoparticles, and cell growth and tissue engineering are the most reported 3D printing technique, type of nanomaterial, and application, respectively. The increase in papers dedicated to these areas is also notable, especially in the 2019 and 2020, when semisolid extrusion became the most used technique, overcoming fused deposition modelling. In fact, this review highlights that the possibility of an alliance between 3D printing and nanotechnology for the production of multiscale materials is undoubtedly a great opportunity for knowledge and innovation in the pharmaceutical and medical area.

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“…In a previous bone regeneration study by Rath and the research team [146], SiO 2 nanoparticles were added into the sodium alginate to produce a scaffold [146]. Sodium alginate and gelatine, are natural polymer hydrogel, that is widely used in tissue engineering using 3-D bioprinting because their properties of biodegradability and biocompatibility [146].…”

Section: Medicalmentioning

confidence: 99%

Recent advancement in 3-D printing: nanocomposites with added functionality

et al. 2021

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3D printable SiO₂ nanoparticle ink for patient specific bone regeneration

Abstract: 3D printing of a complex and irregular virtual defect using SiO2 nanoparticle and hydrogel composite ink for patient specific defect fabrication.

Cited by 59 publications

References 45 publications

Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review

Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review

3D Printing and Nanotechnology: A Multiscale Alliance in Personalized Medicine

Recent advancement in 3-D printing: nanocomposites with added functionality

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3D printable SiO2 nanoparticle ink for patient specific bone regeneration

Abstract: 3D printing of a complex and irregular virtual defect using SiO2 nanoparticle and hydrogel composite ink for patient specific defect fabrication.

Cited by 59 publications

References 45 publications

Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review

Alginate hydrogels for bone tissue engineering, from injectables to bioprinting: A review

3D Printing and Nanotechnology: A Multiscale Alliance in Personalized Medicine

Recent advancement in 3-D printing: nanocomposites with added functionality

Contact Info

Product

Resources

About

3D printable SiO₂ nanoparticle ink for patient specific bone regeneration