3D-printed barium strontium titanate-based piezoelectric scaffolds for bone tissue engineering

Tariverdian, Tara; Behnamghader, Aliasghar; Milan, Peiman Brouki; Bafrooei, Hadi Barzegar; Mozafari, Masoud

doi:10.1016/j.ceramint.2019.04.102

Cited by 54 publications

(37 citation statements)

References 43 publications

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“…Since its invention, MTT has been widely used to measure the cytotoxicity of biomaterials and the growth of cells due to its high sensitivity and economy. For example, Mozafari et al measured the MSCs viability on the 3D-printed barium strontium titanate (BST)/β-tricalcium phosphate (β-TCP) composite scaffolds by MTT [ 52 ]. Specifically, human bone marrow mesenchymal stem cell (hBMSCs) were seeded on the scaffold for 1, 3 and 7 days.…”

Section: The Latest Research Progress Of Traditional Characterizationmentioning

confidence: 99%

Development of methods for detecting the fate of mesenchymal stem cells regulated by bone bioactive materials

Jiang

Liu

Wang

et al. 2021

Bioactive Materials

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The fate of mesenchymal stem cells (MSCs) is regulated by biological, physical and chemical signals. Developments in biotechnology and materials science promoted the occurrence of bioactive materials which can provide physical and chemical signals for MSCs to regulate their fate. In order to design and synthesize materials that can precisely regulate the fate of MSCs, the relationship between the properties of materials and the fate of mesenchymal stem cells need to be clarified, in which the detection of the fate of mesenchymal stem cells plays an important role. In the past 30 years, a series of detection technologies have been developed to detect the fate of MSCs regulated by bioactive materials, among which high-throughput technology has shown great advantages due to its ability to detect large amounts of data at one time. In this review, the latest research progresses of detecting the fate of MSCs regulated by bone bioactive materials (BBMs) are systematically reviewed from traditional technology to high-throughput technology which is emphasized especially. Moreover, current problems and the future development direction of detection technologies of the MSCs fate regulated by BBMs are prospected. The aim of this review is to provide a detection technical framework for researchers to establish the relationship between the properties of BMMs and the fate of MSCs, so as to help researchers to design and synthesize BBMs better which can precisely regulate the fate of MSCs.

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Section: The Latest Research Progress Of Traditional Characterizationmentioning

confidence: 99%

Development of methods for detecting the fate of mesenchymal stem cells regulated by bone bioactive materials

Jiang

Liu

Wang

et al. 2021

Bioactive Materials

View full text Add to dashboard Cite

show abstract

“…The potential effect of this class of materials in bone tissue engineering is due to its dielectric properties, low dielectric loss, and polarization. Sr 2+ ion can increase a dielectric constant, and it is a trace element in the human body that plays a dual role in bone formation and regeneration [2].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, barium titanate-based ceramic with perovskite structure has been widely used as a ferroelectric material for its attractive properties, such as high piezoelectric coefficient (d 33 = 191 pC/N) as well as excellent biocompatibility and bone regeneration capacity in the complex physiological environment, and is further considered as an intelligent material for tissue reconstruction [2][3][4].…”

Section: Introductionmentioning

confidence: 99%

“…One of the best ways to achieve this goal is to use an osteoconductive and porous structure to act as a three-dimensional (3D) porous scaffold [2]. Ideally, osseointegration of the grafted material would be accomplished on a long timescale by the progressive action of osteoclasts, osteoblasts, and osteocytes which remove the graft material and deposit new bone in place [20].…”

Section: Introductionmentioning

confidence: 99%

“…In recent years, the development of 3D printing techniques for the manufacture of ceramic-based scaffold materials has shown promising outcomes [1,2].…”

Section: Introductionmentioning

confidence: 99%

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Innovative Hybrid Materials with Improved Tensile Strength Obtained by 3D Printing

Piticescu¹,

Cursaru²,

Negroiu³

et al. 2020

Biomaterials

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Barium titanate (BT) and barium strontium titanate (BST) are one of the most studied ferroelectric materials with excellent piezoelectric properties, which can be used to stimulate bone formation by applying an electrical field. It is known that this ceramic is biocompatible and can be used for medical applications. New hybrid materials based on BT and collagen and BST and collagen, with potential applications in bone reconstruction, are presented, emphasizing the potential of fabricating 3D structures by integrating hydrothermal synthesis with additive manufacturing. Designing such structures may take advantage of rheological characterization at single-molecule level for some elastic biopolymers like titin and collagen and their molecular dissection into structural motifs that independently contribute to the protein viscoelasticity. Atomic force spectroscopy measurements on synthetic polypeptides showed that a polypeptide chain containing Ig domain modules is protected against rupture at high stretch by Ig domain unfolding, an important mechanism for stress relaxation in titin molecules. This property may be exploited to enhance the tensile strength of a 3D structure by adding specific synthetic polypeptides to the composition of the printing paste.

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3D Printing and Biomedical Applications of Piezoelectric Composites: A Critical Review

Li,

Shan,

Chen

et al. 2024

Adv Materials Technologies

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Piezoelectric composites have received widespread attentions in the fields of biomedicine and in vitro wearable devices due to their ability to convert mechanical forces into charge signals. The preparation of piezoelectric composites with complex structures through 3D printing technology can not only effectively improve their piezoelectric output, but also enable their customized therapeutic applications. This paper first introduces the types of piezoelectric composites and reviews the 3D printing technology commonly used in their preparation, analyzing the advantages and disadvantages of each 3D printing technology. Then, the state‐of‐the‐art of the biomedical applications of piezoelectric composites, including drug sustained‐release, wound healing promotion, bone tissue cells growth promoting, neurorehabilitation stimulating, ultrasonic diagnosis, and in vivo biosensing and in vitro wearable sensing, are emphasized. Finally, the main factors affecting the applications of 3D printed piezoelectric composites are outlooked, and an in‐depth discussion on the challenges toward 3D printed piezoelectric composites are analyzed. This review is believed to provide some fundamental knowledge of 3D printed piezoelectric composites.

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3D-printed barium strontium titanate-based piezoelectric scaffolds for bone tissue engineering

Cited by 54 publications

References 43 publications

Development of methods for detecting the fate of mesenchymal stem cells regulated by bone bioactive materials

Development of methods for detecting the fate of mesenchymal stem cells regulated by bone bioactive materials

Innovative Hybrid Materials with Improved Tensile Strength Obtained by 3D Printing

3D Printing and Biomedical Applications of Piezoelectric Composites: A Critical Review

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