3D-printed biodegradable composite scaffolds with significantly enhanced mechanical properties via the combination of binder jetting and capillary rise infiltration process

Ahn, Jae Hoon; Kim, Jin‐Young; Han, Ginam; Kim, DongEung; Cheon, Kwang-Hee; Lee, Hyun; Kim, Hyoun‐Ee; Kim, Young‐Jig; Jang, Tae‐Sik; Jung, Hyun‐Do

doi:10.1016/j.addma.2021.101988

Cited by 37 publications

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References 86 publications

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“…Because of their good mechanical characteristics and biocompatibility for hard tissue engineering applications, Ahn et al [ 66 ] intensively explored biodegradable composite scaffolds. Three-dimensional printing technologies have sparked a lot of interest in the tissue engineering field because of their ability to be customized for tissues repair.…”

Section: Types Of 3d Printingmentioning

confidence: 99%

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3D Printing and Shaping Polymers, Composites, and Nanocomposites: A Review

et al. 2022

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Sustainable technologies are vital due to the efforts of researchers and investors who have allocated significant amounts of money and time to their development. Nowadays, 3D printing has been accepted by the main industry players, since its first establishment almost 30 years ago. It is obvious that almost every industry is related to technology, which proves that technology has a bright future. Many studies have shown that technologies have changed the methods for developing particular products. Three-dimensional printing has evolved tremendously, and currently, many new types of 3D printing machines have been introduced. In this paper, we describe the historical development of 3D printing technology including its process, types of printing, and applications on polymer materials.

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Section: Types Of 3d Printingmentioning

confidence: 99%

“… FESEM and (inset) optical images of the surface of the 3D printedscaffolds: ( A ) CSH; ( B ) BCP; ( C ) BCP/d-PCL; ( D ) BCP/m-PCL scaffolds (adapted with permission from reference [ 66 ]). …”

Section: Figurementioning

confidence: 99%

3D Printing and Shaping Polymers, Composites, and Nanocomposites: A Review

et al. 2022

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“…PCL-biphasic calcium phosphates). 162 In vivo, its resorption is mediated by the lipase enzyme secreted in the interstitial fluid by cells.…”

Section: Synthetic and Natural Materials For Meniscal Scaffolds Printing Conditioning And Bioprintingmentioning

confidence: 99%

Meniscus regeneration by 3D printing technologies: Current advances and future perspectives

et al. 2022

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Meniscal tears are a frequent orthopedic injury commonly managed by conservative strategies to avoid osteoarthritis development descending from altered biomechanics. Among cutting-edge approaches in tissue engineering, 3D printing technologies are extremely promising guaranteeing for complex biomimetic architectures mimicking native tissues. Considering the anisotropic characteristics of the menisci, and the ability of printing over structural control, it descends the intriguing potential of such vanguard techniques to meet individual joints’ requirements within personalized medicine. This literature review provides a state-of-the-art on 3D printing for meniscus reconstruction. Experiences in printing materials/technologies, scaffold types, augmentation strategies, cellular conditioning have been compared/discussed; outcomes of pre-clinical studies allowed for further considerations. To date, translation to clinic of 3D printed meniscal devices is still a challenge: meniscus reconstruction is once again clear expression of how the integration of different expertise (e.g., anatomy, engineering, biomaterials science, cell biology, and medicine) is required to successfully address native tissues complexities.

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“…On the other hand, the low bioactivity of a single polymer restricted tissue restoration . The preparation of porous 3DP bone scaffolds by adding active Ca, P powders (such as hydroxyapatite (HA), β-tricalcium phosphate (β-TCP), and biphase calcium phosphate (BCP)) into polymers was an effective strategy. − Traditionally, bioactive Ca, P powders were firmly encapsulated in 3DP polymer filaments and gradually released along with polymer degradation, which greatly restricted the inducibility of Ca, P ions in early osteogenesis . Meanwhile, at the microscopic level, the surface of most filament units in 3D printed scaffolds was dense and smooth, which impeded cell adhesion and spreading, and resulted in new tissue loosely wrapped around the filaments, hindering osseointegration .…”

Section: Introductionmentioning

confidence: 99%

Tailorable 3DP Flexible Scaffolds with Porosification of Filaments Facilitate Cell Ingrowth and Biomineralized Deposition

Liu

et al. 2022

ACS Appl. Mater. Interfaces

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Facilitating cell ingrowth and biomineralized deposition inside filaments of 3DP scaffolds are an ideal bone repair strategy. Here, 3D printed PLGA/HA scaffolds with hydroxyapatite content of 50% (P5H5) and 70% (P3H7) were prepared by optimizing 3D printing inks, which exhibited good tailorability and foldability to meet clinical maneuverability. The supercritical CO2 foaming technology further endowed the filaments of P5H5 with a richer interconnected pore structure (P5H5-C). The finite element and computational fluid dynamics simulation analysis indicated that the porosification could effectively reduce the stress concentration at the filament junction and improved the overall permeability of the scaffold. The results of in vitro experiments confirmed that P5H5-C promoted the adsorption of proteins on the surface and inside of filaments, accelerated the release of Ca and P ions, and significantly upregulated osteogenesis (Col I, ALP, and OPN)- and angiogenesis (VEGF)-related gene expression. Subcutaneous ectopic osteogenesis experiments in nude mice further verified that P5H5-C facilitated cell growth inside filaments and biomineralized deposition, as well as significantly upregulated the expression of osteogenesis- and angiogenesis-related genes (Col I, ALP, OCN, and VEGF) and protein secretion (ALP, RUNX2, and VEGF). The porosification of filaments by supercritical CO2 foaming provided a new strategy for accelerating osteogenesis of 3DP implants.

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3D-printed biodegradable composite scaffolds with significantly enhanced mechanical properties via the combination of binder jetting and capillary rise infiltration process

Cited by 37 publications

References 86 publications

3D Printing and Shaping Polymers, Composites, and Nanocomposites: A Review

3D Printing and Shaping Polymers, Composites, and Nanocomposites: A Review

Meniscus regeneration by 3D printing technologies: Current advances and future perspectives

Tailorable 3DP Flexible Scaffolds with Porosification of Filaments Facilitate Cell Ingrowth and Biomineralized Deposition

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