3D Printed Bioelectronic Platform with Embedded Electronics

Agarwala, Shweta; Lee, Jia Min; Yeong, Wai Yee; Layani, Michael; Magdassi, Shlomo

doi:10.1557/adv.2018.431

Cited by 10 publications

(8 citation statements)

References 11 publications

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“…It is The copyright holder for this preprint this version posted July 2, 2020. ; https://doi.org/10.1101/2020.06.30.181214 doi: bioRxiv preprint Figure 3B shows the PrestoBlue ® assay results, conducted to measure the metabolic activity of our cell-seeded fibers. We observed a gradual and substantial increase in activity over the first 12 days in all cases (i.e., GelMA fibers with or without TuMV), which is expected at proliferation stages and has also been reported for C2C12 cells seeded on GelMA scaffolds [36,37]. All samples followed approximately the same trend the first 6 days, but in the following days they exhibited significantly different behaviors (p*<0.05).…”

Section: Hydrogel Fibers As Cell Scaffoldssupporting

confidence: 80%

Biofabrication of muscle fibers enhanced with plant viral nanoparticles using surface chaotic flows

et al. 2021

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Multiple human tissues exhibit fibrous nature. Therefore, the fabrication of hydrogel filaments for tissue engineering is a trending topic. Current tissue models are made of materials that often require further enhancement for appropriate cell attachment, proliferation and differentiation. Here we present a simple strategy, based on the use surface chaotic flows amenable of mathematical modeling, to fabricate continuous, long and thin filaments of gelatin methacryloyl (GelMA).The fabrication of these filaments is achieved by chaotic advection in a finely controlled and miniaturized version of the journal bearing (JB) system. A drop of GelMA pregel was injected on a higher-density viscous fluid (glycerin) and a chaotic flow is applied through an iterative process.The hydrogel drop is exponentially deformed and elongated to generate a fiber, which was then polymerized under UV-light exposure. Computational fluid dynamic (CFD) simulations are conducted to determine the characteristics of the flow and design the experimental conditions for fabrication of the fibers. GelMA fibers were effectively used as scaffolds for C2C12 myoblast cells..

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Section: Hydrogel Fibers As Cell Scaffoldssupporting

confidence: 80%

Biofabrication of muscle fibers enhanced with plant viral nanoparticles using surface chaotic flows

et al. 2021

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“…Figure 3B shows the PrestoBlue ® assay results, conducted to measure the metabolic activity of our cell-seeded fibers. We observed a gradual and substantial increase in activity over the first 12 days in all cases (i.e., GelMA fibers with or without TuMV), which is expected at proliferation stages and has also been reported for C2C12 cells seeded on GelMA scaffolds [36,37]. All samples followed approximately the same trend the first 6 days, but in the following days they exhibited significantly different behaviors (p*<0.05).…”

Section: Hydrogel Fibers As Cell Scaffoldssupporting

confidence: 80%

Biofabrication of muscle fibers enhanced with plant viral nanoparticles using surface chaotic flows

Frías-Sánchez

Quevedo‐Moreno

Samandari

et al. 2020

Preprint

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AbstractMultiple human tissues exhibit fibrous nature. Therefore, the fabrication of hydrogel filaments for tissue engineering is a trending topic. Current tissue models are made of materials that often require further enhancement for appropriate cell attachment, proliferation and differentiation. Here we present a simple strategy, based on the use surface chaotic flows amenable of mathematical modeling, to fabricate continuous, long and thin filaments of gelatin methacryloyl (GelMA).The fabrication of these filaments is achieved by chaotic advection in a finely controlled and miniaturized version of the journal bearing (JB) system. A drop of GelMA pregel was injected on a higher-density viscous fluid (glycerin) and a chaotic flow is applied through an iterative process. The hydrogel drop is exponentially deformed and elongated to generate a fiber, which was then polymerized under UV-light exposure. Computational fluid dynamic (CFD) simulations are conducted to determine the characteristics of the flow and design the experimental conditions for fabrication of the fibers. GelMA fibers were effectively used as scaffolds for C2C12 myoblast cells. Experimental results demonstrate an accurate accordance with CFD simulations for the predicted length of the fibers.Plant-based viral nanoparticles (i.e., Turnip mosaic virus; TuMV) were then integrated to the hydrogel fibers as a secondary nano-scaffold for cells for enhanced muscle tissue engineering. The addition of TuMV significantly increased the metabolic activity of the cell-seeded fibers (p*<0.05), strengthened cell attachment throughout the first 28 days, improved cell alignment, and promoted the generation of structures that resemble natural mammal muscle tissues.Chaotic 2D-printing is proven to be a viable method for the fabrication of hydrogel fibers. The combined use of thin and long GelMA hydrogel fibers enhanced with flexuous virions offers a promising alternative for scaffolding of muscle cells and show potential to be used as cost-effective models for muscle tissue engineering purposes.

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“…21). [208][209][210][211][212][213] 5 Future development directions for hydrogel bioelectronics During the last decade, the tremendous amount of efforts highlighted above has driven rapid progress in this nascent field. Hydrogels have found their unique role in numerous stimulation and recording applications as bioelectronic and biomechanical bridging interfaces.…”

Section: Fabrication Of Hydrogel Interfacesmentioning

confidence: 99%