2017
DOI: 10.1016/j.jmbbm.2017.05.016
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3D-printed biomaterials with regional auxetic properties

Abstract: Tissue engineering is replete with methods for inducing and mediating cell differentiation, which are crucial for ensuring proper regrowth of desired tissues. In this study, we developed a 3D-printed, non-positive Poisson's Ratio (NPPR) scaffold intended for future use in stretch-mediated cell differentiation applications, such as in muscle and tendon regeneration. We utilized dynamic optical projection stereolithography (DOPsL) to fabricate multi-layered, cell-laden NPPR scaffolds – these scaffolds can not on… Show more

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Cited by 53 publications
(30 citation statements)
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“…Material selection is one of the many considerations to be taken into account when fabricating auxetic tissue engineering scaffolds. Only synthetic materials have been previously used in the fabrication of auxetic scaffolds [18][19][20][21][22][23][24][25][26][27] due to the difficulty of manipulating natural materials such as ECM. The cyto-compatability and cellular adhesion should be considered and has been demonstrated in all studies developing auxetic scaffolds [18][19][20][21][22][23][24][25][26][27] .…”
Section: Significance Of Auxetic Materials In Tissue Engineeringmentioning
confidence: 99%
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“…Material selection is one of the many considerations to be taken into account when fabricating auxetic tissue engineering scaffolds. Only synthetic materials have been previously used in the fabrication of auxetic scaffolds [18][19][20][21][22][23][24][25][26][27] due to the difficulty of manipulating natural materials such as ECM. The cyto-compatability and cellular adhesion should be considered and has been demonstrated in all studies developing auxetic scaffolds [18][19][20][21][22][23][24][25][26][27] .…”
Section: Significance Of Auxetic Materials In Tissue Engineeringmentioning
confidence: 99%
“…Only synthetic materials have been previously used in the fabrication of auxetic scaffolds [18][19][20][21][22][23][24][25][26][27] due to the difficulty of manipulating natural materials such as ECM. The cyto-compatability and cellular adhesion should be considered and has been demonstrated in all studies developing auxetic scaffolds [18][19][20][21][22][23][24][25][26][27] . For eventual implantation applications the biocompatibility and Tri-axial compression has been employed to create auxetic scaffolds from polyurethane 20,25,26 and poly(lactic-co-glycolic acid) (PLGA) 22,23 with similar results to the triaxial compression of polyurethane foam (Figure 4).…”
Section: Significance Of Auxetic Materials In Tissue Engineeringmentioning
confidence: 99%
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“…Poisson's ratio is another important mechanical property that has yet to be fully explored in the bioengineering field, primarily due to the limited manufacturing capabilities in controlling the Poisson's ratio of the biological constructs using traditional biofabrication techniques. 56,57 In comparison to the Young's modulus, which measures a material's elastic behavior along the axial direction of the applied stress, Poisson's ratio defines the material's deformation (i.e., shrinkage or expansion) in the transverse direction that is perpendicular to the stress loading direction. In nature, a vast majority of materials possess a positive Poisson's ratio such that they experience a reduction in size in the transverse direction while being stretched in the axial direction.…”
Section: Controlling Poisson's Ratiomentioning
confidence: 99%
“…In recent years, advanced 3D printing platforms have emerged as a powerful tool for building artificial scaffolds with precise control over the Poisson's ratio for interesting biological applications. [56][57][58][59][60]62 In one example, the fabrication of single-and multi-layer web structures with negative, zero, and positive Poisson's ratios were achieved by using DLP-based 3D printers with PEG-based biomaterials. 58,59,62 Poisson's ratio structure and negative Poisson's ratio structures together.…”
Section: Controlling Poisson's Ratiomentioning
confidence: 99%