3D printed biomimetic epithelium/stroma bilayer hydrogel implant for corneal regeneration

He, Binbin; Wang, Jie; Xie, Mengtian; Xu, Miaoyi; Zhang, Yahan; Hao, Huijie; Xing, Xiaoli; Lu, William W.; Han, Qiang; Liu, Wenguang

doi:10.1016/j.bioactmat.2022.01.034

Cited by 50 publications

(89 citation statements)

References 57 publications

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“…During this photo-activation process, the N 3 • could also be generated from Pt(IV). Given the radicals triggered photo-crosslinking in many photo-cross-linkable hydrogels [ [42] , [43] , [44] ], we envision that the polymerization of these hydrogels could be initiated by N 3 • . Besides, oxygen could also be generated during this process; which is crucial for ROS production by photosensitizers (PSs) [ 45 , 46 ].…”

Section: Introductionmentioning

confidence: 99%

Pt(IV) prodrug initiated microparticles from microfluidics for tumor chemo-, photothermal and photodynamic combination therapy

Zhang

Wang

Kuang

et al. 2023

Bioactive Materials

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Section: Introductionmentioning

confidence: 99%

Pt(IV) prodrug initiated microparticles from microfluidics for tumor chemo-, photothermal and photodynamic combination therapy

Zhang

Wang

Kuang

et al. 2023

Bioactive Materials

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“…In vitro cell viability was not reduced either after seeding cells onto the surface of hydrogel or after printing cells within the gelatin-based ink. In addition, animal tests proved that 3D hydrogel was able to regenerate the cornea by stromal generation and re-epithelization [110].…”

Section: Gelatin As Bioink For 3d Printingmentioning

confidence: 99%

“…As mentioned above, 3D printing has paved the way towards clinical use by designing high-precision and sophisticated systems, alongside high cost-effectiveness. Since gelatin is able to crosslink in situ as well as to provide biologically suitable properties (ability to promote cell adhesion, proliferation and differentiation), gelatin-based inks or its derivatives (for instance, GelMA) have been extensively exploited in several tissues such as bone, skin and cornea [107][108][109][110].…”

Section: Gelatin As Bioink For 3d Printingmentioning

confidence: 99%

Progress in Gelatin as Biomaterial for Tissue Engineering

et al. 2022

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Tissue engineering has become a medical alternative in this society with an ever-increasing lifespan. Advances in the areas of technology and biomaterials have facilitated the use of engineered constructs for medical issues. This review discusses on-going concerns and the latest developments in a widely employed biomaterial in the field of tissue engineering: gelatin. Emerging techniques including 3D bioprinting and gelatin functionalization have demonstrated better mimicking of native tissue by reinforcing gelatin-based systems, among others. This breakthrough facilitates, on the one hand, the manufacturing process when it comes to practicality and cost-effectiveness, which plays a key role in the transition towards clinical application. On the other hand, it can be concluded that gelatin could be considered as one of the promising biomaterials in future trends, in which the focus might be on the detection and diagnosis of diseases rather than treatment.

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“…Besides its efficacy in corneal bioprinting, this method also has the potential in fabrication of other shell-like or hollow structures with complex surfaces (Zhang et al, 2019b). In 2022, He B et al used DLP-bioprinting to build biomimetic epithelium/stroma bilayer hydrogel implant for corneal regeneration (He et al, 2022). Though both CAD designed plain, and dome-shaped model were printed, the stepwise pattern resulting from the unsatisfying resolution and friability resulting from the mechanical properties of the biomaterial makes the printed dome-shaped hydrogel construct impossible for in-vivo models.…”

Section: Diverse Bioprinting Techniquesmentioning

confidence: 99%

Advances in 3D bioprinting technology for functional corneal reconstruction and regeneration

Jia

Lau

et al. 2023

Front. Bioeng. Biotechnol.

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Corneal transplantation constitutes one of the major treatments in severe cases of corneal diseases. The lack of cornea donors as well as other limitations of corneal transplantation necessitate the development of artificial corneal substitutes. Biosynthetic cornea model using 3D printing technique is promising to generate artificial corneal structure that can resemble the structure of the native human cornea and is applicable for regenerative medicine. Research on bioprinting artificial cornea has raised interest into the wide range of materials and cells that can be utilized as bioinks for optimal clarity, biocompatibility, and tectonic strength. With continued advances in biomaterials science and printing technology, it is believed that bioprinted cornea will eventually achieve a level of clinical functionality and practicality as to replace donated corneal tissues, with their associated limitations such as limited or unsteady supply, and possible infectious disease transmission. Here, we review the literature on bioprinting strategies, 3D corneal modelling, material options, and cellularization strategies in relation to keratoprosthesis design. The progress, limitations and expectations of recent cases of 3D bioprinting of artifial cornea are discussed. An outlook on the rise of 3D bioprinting in corneal reconstruction and regeneration is provided.

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3D printed biomimetic epithelium/stroma bilayer hydrogel implant for corneal regeneration

Cited by 50 publications

References 57 publications

Pt(IV) prodrug initiated microparticles from microfluidics for tumor chemo-, photothermal and photodynamic combination therapy

Pt(IV) prodrug initiated microparticles from microfluidics for tumor chemo-, photothermal and photodynamic combination therapy

Progress in Gelatin as Biomaterial for Tissue Engineering

Advances in 3D bioprinting technology for functional corneal reconstruction and regeneration

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