3D Printed Bioscaffolds for Developing Tissue-Engineered Constructs

Chowdhury, Shiplu Roy; Lokanathan, Yogeswaran; Law, Jia Xian; Busra, Fauzi M.; Yazid, Muhammad Dain; Sulaiman, Nadiah; Lahiry, Gargy; Hoque, Enamul

doi:10.5772/intechopen.92418

Cited by 4 publications

(2 citation statements)

References 101 publications

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“…Tissue-engineered constructs are artificial structures that are created using cells and biomaterials and can be used for tissue engineering applications. Scaffolds are 3D structures that provide support for cells to grow and differentiate, and can be used for tissue engineering, drug screening, and regenerative medicine applications [ 116 , 117 , 118 , 119 , 120 ]. In summary, while organoids, spheroids, and other 3D structures have some similarities, they can be distinguished by their cellular organization, complexity, and functional specialization.…”

Section: Cell Culture System—from 2d To 3dmentioning

confidence: 99%

Revolutionizing Disease Modeling: The Emergence of Organoids in Cellular Systems

Silva-Pedrosa

Salgado

Ferreira

2023

Cells

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Cellular models have created opportunities to explore the characteristics of human diseases through well-established protocols, while avoiding the ethical restrictions associated with post-mortem studies and the costs associated with researching animal models. The capability of cell reprogramming, such as induced pluripotent stem cells (iPSCs) technology, solved the complications associated with human embryonic stem cells (hESC) usage. Moreover, iPSCs made significant contributions for human medicine, such as in diagnosis, therapeutic and regenerative medicine. The two-dimensional (2D) models allowed for monolayer cellular culture in vitro; however, they were surpassed by the three-dimensional (3D) cell culture system. The 3D cell culture provides higher cell–cell contact and a multi-layered cell culture, which more closely respects cellular morphology and polarity. It is more tightly able to resemble conditions in vivo and a closer approach to the architecture of human tissues, such as human organoids. Organoids are 3D cellular structures that mimic the architecture and function of native tissues. They are generated in vitro from stem cells or differentiated cells, such as epithelial or neural cells, and are used to study organ development, disease modeling, and drug discovery. Organoids have become a powerful tool for understanding the cellular and molecular mechanisms underlying human physiology, providing new insights into the pathogenesis of cancer, metabolic diseases, and brain disorders. Although organoid technology is up-and-coming, it also has some limitations that require improvements.

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Section: Cell Culture System—from 2d To 3dmentioning

confidence: 99%

Revolutionizing Disease Modeling: The Emergence of Organoids in Cellular Systems

Silva-Pedrosa

Salgado

Ferreira

2023

Cells

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“…They prevent negative tissue responses, are nonhemolytic, and less immunogenic due to their polysaccharide composition and promote cellular connection and tissue growth. The biomedical industry (Figure 17) uses them for skin replacements, drug-releasing systems, gum, nerves, dura mater reconstruction, stent covering, and scaffolds for tissue engineering [90][91][92][93][94]. BNC is a suitable biomaterial for promoting bone regenerative processes.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Synthesis, Properties, Applications, and Future Prospective of Cellulose Nanocrystals

Rashid,

Hoque,

Kabir

et al. 2023

Polymers

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The exploration of nanocellulose has been aided by rapid nanotechnology and material science breakthroughs, resulting in their emergence as desired biomaterials. Nanocellulose has been thoroughly studied in various disciplines, including renewable energy, electronics, environment, food production, biomedicine, healthcare, and so on. Cellulose nanocrystal (CNC) is a part of the organic crystallization of macromolecular compounds found in bacteria’s capsular polysaccharides and plant fibers. Owing to numerous reactive chemical groups on its surface, physical adsorption, surface grating, and chemical vapor deposition can all be used to increase its performance, which is the key reason for its wide range of applications. Cellulose nanocrystals (CNCs) have much potential as suitable matrices and advanced materials, and they have been utilized so far, both in terms of modifying and inventing uses for them. This work reviews CNC’s synthesis, properties and various industrial applications. This review has also discussed the widespread applications of CNC as sensor, acoustic insulator, and fire retardant material.

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