3D-printed cellular structures for bone biomimetic implants

Limmahakhun, Sakkadech; Oloyede, Adekunle; Sitthiseripratip, Kriskrai; Xiao, Yin; Chen, Yan

doi:10.1016/j.addma.2017.03.010

Cited by 91 publications

(73 citation statements)

References 34 publications

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“…The form of the endoprosthesis should allow the insertion of bone material into the endoprosthesis to improve the growth of bone tissue [6]. In Figure 1, the long bone (a) and long bone with lattice endoprosthesis (b) are schematically shown.…”

Section: Methodsmentioning

confidence: 99%

“…Figure 3 shows the diagram of the inner chamber, the length of which is 1500 mm, the height of 800 mm. The chamber is hermetic and allows creating an atmosphere of inert gas (9), in the chamber to the left is a metal roller for applying powder (6), it has the possibility of horizontal movement throughout the chamber. In the middle, there is a box (3) with a powder inside which a movable piston is located, on the right (2) is a construction zone consisting of a movable piston with a platform and a laser (8) mounted above it.…”

Section: Methodsmentioning

confidence: 99%

“…Traditionally manufactured lattice constructions using casting and forging techniques cannot achieve the levels of additive manufacturing. However, problems appear because of melting: A manifestation of brittle properties and geometry deviations [4][5][6][7]. Different materials and melting modes are investigated to improve the quality of constructions [8][9][10].…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Design and Optimization Lattice Endoprosthesis for Long Bones: Manufacturing and Clinical Experiment

Bolshakov

Raginov

Egorov³

et al. 2020

Materials

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The article is devoted to the construction of lattice endoprosthesis for a long bone. Clinically, the main idea is to design a construction with the ability to improve bone growth. The article presents the algorithm for such a design. The construction should be produced by additive manufacturing. Such an approach allows using not only metallic materials but also ceramics and polymers. The algorithm is based on the influence function as a method to describe the elementary cell geometry. The elementary cell can be described by a number of parameters. The influence function maps the parameters to local stress in construction. Changing the parameters influences the stress distribution in the endoprosthesis. In the paper, a bipyramid was used as an elementary cell. Numerical studies were performed using the finite element method. As a result, manufacturing construction is described. Some problems for different orientations of growth are given. The clinical test was done and histological results were presented.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Design and Optimization Lattice Endoprosthesis for Long Bones: Manufacturing and Clinical Experiment

Bolshakov

Raginov

Egorov³

et al. 2020

Materials

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“…Limmahakhun et al [26] emphasized that the internal architectures of scaffolds play a crucial role in determining the overall mechanical and biological performances. It is interesting to note that the mechanical response from a cellular structure depends on the loading modes.…”

Section: Additive Manufacturing (Am) Techniquesmentioning

confidence: 99%

Graded Cellular Bone Scaffolds

Limmahakhun¹,

Chen²

2017

Scaffolds in Tissue Engineering - Materials, Technologies and Clinical Applications

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Bone scaffolds with graded porosities or graded cellular bone scaffolds are new innovations of bone replacements and biomedical bone implants, especially in cases of long-bone defects, multitissue regenerations, and functional-controlled bone prostheses. The concepts of graded cellular bone scaffolds are based on the complexity of bone characteristics (graded hierarchical structures and heterogeneity), which aims to closer replicate the multifunctions of bone tissues. The designs of graded cellular bone scaffolds are highly fascinating with the relative anatomical, biological, and mechanical similarity to the replaced bones. While it is difficult for the graded designs to replicate the actual bone models, additive manufacturing (AM) techniques with computer-aided designs successfully create well-controlled models with comparable bone properties. Potential advantages of graded cellular bone scaffolds are enormous. Graded pores can direct types of cell regenerations for multitissue regenerations. Furthermore, graded pores promote a greater load-sharing to adjacent bone tissues than conventional scaffolds do, while both mechanical properties are similar. To summarize, bone implants with graded cellular structures can be fabricated using AM techniques, and their mechanical and biological performances can be tailored by modifying the internal architectures.

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“…Wang Chunxiao [20] et al designed and manufactured titanium alloy scaffolds with different pore structures using metal 3D printing technology, and observed its micro-pore characteristics and mechanical properties. Sakkadech Limmahakhun [21,22] et al taking the cylindrical octahedron structure as a unit, fabricated four kinds of porous structures with different pore size by Selective laser melting technology, and testing their mechanical properties and biological behavior. Li X [23] et al studied the surface properties [24,25], mechanical properties [26,27], and its biological behavior [28,29] of porous titanium alloy made by electron beam melting (EBM).…”

Section: Introductionmentioning

confidence: 99%

Mechanical behavior of a titanium alloy scaffold mimicking trabecular structure

Zhang

Liu³

et al. 2020

J Orthop Surg Res

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Background: Additively manufactured porous metallic structures have recently received great attention for bone implant applications. The morphological characteristics and mechanical behavior of 3D printed titanium alloy trabecular structure will affect the effects of artificial prosthesis replacement. However, the mechanical behavior of titanium alloy trabecular structure at present clinical usage still is lack of in-depth study from design to manufacture as well as from structure to mechanical function. Methods: A unit cell of titanium alloy was designed to mimick trabecular structure. The controlled microarchitecture refers to a repeating array of unit-cells, composed of titanium alloy, which make up the scaffold structure. Five kinds of unit cell mimicking trabecular structure with different pore sizes and porosity were obtained by modifying the strut sizes of the cell and scaling the cell as a whole. The titanium alloy trabecular structure was fabricated by 3D printing based on Electron Beam Melting (EBM). The paper characterized the difference between the designs and fabrication of trabecular structures, as well as mechanical properties and the progressive collapse behavior and failure mechanism of the scaffold. Results: The actual porosities of the EBM-produced bone trabeculae are lower than the designed, and the load capacity of a bearing is related to the porosity of the structure. The larger the porosity of the structure, the smaller the stiffness and the worse the load capacity is. The fracture interface of the trabecular structure under compression is at an angle of 45 o with respect to the compressive axis direction, which conforms to Tresca yield criterion. The trabeculae-mimicked unit cell is anisotropy. Under quasi-static loading, loading speed has no effect on mechanical performance of bone trabecular specimens. There is no difference of the mechanical performance at various orientations and sites in metallic workspace. The elastic modulus of the scaffold decreases by 96%-93% and strength reduction 96%-91%, compared with titanium alloy dense metals structure. The apparent elastic modulus of the unit-cell-repeated scaffold is 0.39-0.618 GPa, which is close to that of natural bone and stress shielding can be reduced. Conclusion: We have systematically studied the structural design, fabrication and mechanical behavior of a 3D printed titanium alloy scaffold mimicking trabecula bone. This study will be benefit of the application of prostheses with proper structures and functions.

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3D-printed cellular structures for bone biomimetic implants

Cited by 91 publications

References 34 publications

Design and Optimization Lattice Endoprosthesis for Long Bones: Manufacturing and Clinical Experiment

Design and Optimization Lattice Endoprosthesis for Long Bones: Manufacturing and Clinical Experiment

Graded Cellular Bone Scaffolds

Mechanical behavior of a titanium alloy scaffold mimicking trabecular structure

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