3D printed enzymatic microchip for multiplexed electrochemical biosensing

Koukouviti, Eleni; Kokkinos, Christos

doi:10.1016/j.aca.2021.339114

Cited by 24 publications

(14 citation statements)

References 35 publications

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“…[ 299 ] A novel micro 3D‐printed electrode biochip enabled simultaneous measurement of multiple biomarkers, including cholesterol and choline. [ 300 ]…”

Section: Applications and Devicesmentioning

confidence: 99%

Biointerface Coatings With Structural and Biochemical Properties Modifications of Biomaterials

Lee

Christy

et al. 2023

Adv Materials Inter

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fundamental properties from the physical perspective (e.g., surface roughness, hydrophobicity, elasticity, surface structure/ geometry, and mechanical strength) and the chemical perspective (e.g., bio and/or chemical functionality) can affect cellular responses, including cell attachment, proliferation, migration, differentiation, and apoptosis. [1][2][3][4] For instance, cells respond extensively to synthetic extracellular matrix (ECM) on substrates with multiple features, such as chemical composition, geometry and topological features, ligand organization, and substrate stiffness. [5][6][7][8]

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“…[ 299 ] A novel micro 3D‐printed electrode biochip enabled simultaneous measurement of multiple biomarkers, including cholesterol and choline. [ 300 ]…”

Section: Applications and Devicesmentioning

confidence: 99%

Biointerface Coatings With Structural and Biochemical Properties Modifications of Biomaterials

Lee

Christy

et al. 2023

Adv Materials Inter

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“…Koukouviti et al reported an alternative type of multiplexed electrochemical sensor for monitoring cardiac biomarkers ( Figure 4 b) [ 107 ]. A 3D-printed 4-electrode enzymatic biosensor for simultaneous measurement of cholesterol and choline was developed by this group.…”

Section: Biosensor Platformsmentioning

confidence: 99%

“…( a ) Multiplexed ePAD for cTnI, PCT, and CRP detection [ 106 ]. ( b ) Fabrication process of the 3D printed biosensor for amperometric detection of cholesterol and choline [ 107 ]. ( c ) A 32-sensor array with microwells with a microfluidic chamber for simultaneous detection of prostate cancer biomarker proteins [ 109 ].…”

Section: Figurementioning

confidence: 99%

Towards Multiplexed and Multimodal Biosensor Platforms in Real-Time Monitoring of Metabolic Disorders

Chung

Nguyen

Zhang

et al. 2022

Sensors

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Metabolic syndrome (MS) is a cluster of conditions that increases the probability of heart disease, stroke, and diabetes, and is very common worldwide. While the exact cause of MS has yet to be understood, there is evidence indicating the relationship between MS and the dysregulation of the immune system. The resultant biomarkers that are expressed in the process are gaining relevance in the early detection of related MS. However, sensing only a single analyte has its limitations because one analyte can be involved with various conditions. Thus, for MS, which generally results from the co-existence of multiple complications, a multi-analyte sensing platform is necessary for precise diagnosis. In this review, we summarize various types of biomarkers related to MS and the non-invasively accessible biofluids that are available for sensing. Then two types of widely used sensing platform, the electrochemical and optical, are discussed in terms of multimodal biosensing, figure-of-merit (FOM), sensitivity, and specificity for early diagnosis of MS. This provides a thorough insight into the current status of the available platforms and how the electrochemical and optical modalities can complement each other for a more reliable sensing platform for MS.

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“…104 To date, most applications of 3D printed electrodes are focused on energy storage and conversion 105,106 applications and it has been demonstrated that 3D printed electrodes with commercial filaments are not directly active upon printing but require chemical and/or physical activation methods to render their surface highly electroactive. 107 Nevertheless, pristine 3D printed electrodes are still conductive enough to fabricate immunosensors for C-reactive protein 108 or enzymatic biosensors for cholesterol and choline 109 using multi-material 3D printing to print electrodes and electrochemical cells in a single print to obtain a fully functional device. Hence, more research is needed in the post-activation and modification steps of the electrodes and ideally in the formulation of conductive filaments to provide highly electrochemically active as-printed devices.…”

Section: Real-time Electrochemical Sensing: An Enriching Complement T...mentioning

confidence: 99%

Digital manufacturing for accelerating organ-on-a-chip dissemination and electrochemical biosensing integration

et al. 2022

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3D printed enzymatic microchip for multiplexed electrochemical biosensing

Cited by 24 publications

References 35 publications

Biointerface Coatings With Structural and Biochemical Properties Modifications of Biomaterials

Biointerface Coatings With Structural and Biochemical Properties Modifications of Biomaterials

Towards Multiplexed and Multimodal Biosensor Platforms in Real-Time Monitoring of Metabolic Disorders

Digital manufacturing for accelerating organ-on-a-chip dissemination and electrochemical biosensing integration

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