3D-printed fish gelatin scaffolds for cartilage tissue engineering

Maihemuti, Abudureheman; Zhang, Han; Lin, Xiang; Wang, Yangyufan; Xu, Zheng; Zhang, Dagan; Jiang, Qing

doi:10.1016/j.bioactmat.2023.02.007

Cited by 34 publications

(20 citation statements)

References 52 publications

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“…Maihemuti et al presented an innovative method for regenerating osteoarticular cartilage by employing a 3D-printed porous multilayer scaffold made of gelatin sourced from fish skin. 166 To improve viscosity, printability, and mechanical strength, gelatin was combined with sodium alginate. The hybrid hydrogels can be printed using a 3D printer based on digitally predesigned structures.…”

Section: Applications Of Gelatin Of Micro/nanostructures In Therapeut...mentioning

confidence: 99%

Chemical and Structural Engineering of Gelatin-Based Delivery Systems for Therapeutic Applications: A Review

Jia,

Fan,

Chen

et al. 2024

Biomacromolecules

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As a biodegradable and biocompatible protein derived from collagen, gelatin has been extensively exploited as a fundamental component of biological scaffolds and drug delivery systems for precise medicine. The easily engineered gelatin holds great promise in formulating various delivery systems to protect and enhance the efficacy of drugs for improving the safety and effectiveness of numerous pharmaceuticals. The remarkable biocompatibility and adjustable mechanical properties of gelatin permit the construction of active 3D scaffolds to accelerate the regeneration of injured tissues and organs. In this Review, we delve into diverse strategies for fabricating and functionalizing gelatin-based structures, which are applicable to gene and drug delivery as well as tissue engineering. We emphasized the advantages of various gelatin derivatives, including methacryloyl gelatin, polyethylene glycolmodified gelatin, thiolated gelatin, and alendronate-modified gelatin. These derivatives exhibit excellent physicochemical and biological properties, allowing the fabrication of tailor-made structures for biomedical applications. Additionally, we explored the latest developments in the modulation of their physicochemical properties by combining additive materials and manufacturing platforms, outlining the design of multifunctional gelatin-based micro-, nano-, and macrostructures. While discussing the current limitations, we also addressed the challenges that need to be overcome for clinical translation, including high manufacturing costs, limited application scenarios, and potential immunogenicity. This Review provides insight into how the structural and chemical engineering of gelatin can be leveraged to pave the way for significant advancements in biomedical applications and the improvement of patient outcomes.

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Section: Applications Of Gelatin Of Micro/nanostructures In Therapeut...mentioning

confidence: 99%

Chemical and Structural Engineering of Gelatin-Based Delivery Systems for Therapeutic Applications: A Review

Jia,

Fan,

Chen

et al. 2024

Biomacromolecules

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“…Hyaluronic acid (HA) is a naturally occurring glycosaminoglycan crucial in forming and maintaining healthy cartilage. Due to its high biocompatibility and stable binding to cell surface receptors, HA has been included as a potential scaffold material for cartilage tissue engineering . HA-based scaffolds have shown promising results in promoting the growth and differentiation of chondrocytes and regeneration of cartilage tissue in animal models.…”

Section: Overview Of Polysaccharide-based Polymers and Their Propertiesmentioning

confidence: 99%

Advances in Polysaccharides for Cartilage Tissue Engineering Repair: A Review

An,

Zhang,

et al. 2024

Biomacromolecules

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Cartilage repair has been a significant challenge in orthopedics that has not yet been fully resolved. Due to the absence of blood vessels and the almost cell-free nature of mature cartilage tissue, the limited ability to repair cartilage has resulted in significant socioeconomic pressures. Polysaccharide materials have recently been widely used for cartilage tissue repair due to their excellent cell loading, biocompatibility, and chemical modifiability. They also provide a suitable microenvironment for cartilage repair and regeneration. In this Review, we summarize the techniques used clinically for cartilage repair, focusing on polysaccharides, polysaccharides for cartilage repair, and the differences between these and other materials. In addition, we summarize the techniques of tissue engineering strategies for cartilage repair and provide an outlook on developing next-generation cartilage repair and regeneration materials from polysaccharides. This Review will provide theoretical guidance for developing polysaccharide-based cartilage repair and regeneration materials with clinical applications for cartilage tissue repair and regeneration.

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“…3D printing is recently recognized as an approach with tremendous potential for producing geometrical specified constructions, considerably enhancing their physiological significance thru engineering resembling of native organs. 30,[52][53][54] This fabrication method enables the modulation of certain factors, including heterogeneity, construct size, matrix stiffness, and cell density, which promotes the management and development of additional complexity. Consequently, the 3D printing technique has been applied in the development of diverse tissue scaffolds to fully mimic the target tissue structure in vitro.…”

Section: D Printingmentioning

confidence: 99%

Construction of cardiac fibrosis for biomedical research

Shang,

Liu,

Gan

et al. 2023

Smart Medicine

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Cardiac remodeling is critical for effective tissue recuperation, nevertheless, excessive formation and deposition of extracellular matrix components can result in the onset of cardiac fibrosis. Despite the emergence of novel therapies, there are still no lifelong therapeutic solutions for this issue. Understanding the detrimental cardiac remodeling may aid in the development of innovative treatment strategies to prevent or reverse fibrotic alterations in the heart. Further combining the latest understanding of disease pathogenesis with cardiac tissue engineering has provided the conversion of basic laboratory studies into the therapy of cardiac fibrosis patients as an increasingly viable prospect. This review presents the current main mechanisms and the potential tissue engineering of cardiac fibrosis. Approaches using biomedical materials‐based cardiac constructions are reviewed to consider key issues for simulating in vitro cardiac fibrosis, outlining a future perspective for preclinical applications.

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3D-printed fish gelatin scaffolds for cartilage tissue engineering

Cited by 34 publications

References 52 publications

Chemical and Structural Engineering of Gelatin-Based Delivery Systems for Therapeutic Applications: A Review

Chemical and Structural Engineering of Gelatin-Based Delivery Systems for Therapeutic Applications: A Review

Advances in Polysaccharides for Cartilage Tissue Engineering Repair: A Review

Construction of cardiac fibrosis for biomedical research

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