3D printed lens for depth of field imaging

Kiekens, Kelli C.; Barton, Jennifer K.

doi:10.1364/osac.2.003019

Cited by 11 publications

(7 citation statements)

References 10 publications

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“…To achieve the desired 60° FFOV, a custom lens is required. Our lab has been looking into replacing the GRIN lens with a 3D printed lens [15] giving us optical design flexibility while keeping cost and manufacturing time low. Another future improvement to this project is to incorporate a motorized pull back mechanism inside the handle for automated OCT scanning.…”

Section: Discussionmentioning

confidence: 99%

Reengineering a falloposcope imaging system for clinical use

Kiekens

Romano

Galvez

et al. 2020

Transl Biophotonics

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High-grade serous carcinoma of the ovary is believed to originate in the fallopian tubes (FTs). A submillimeter diameter endoscope with advanced imaging capabilities may take advantage of the natural pathway of the female reproductive tract to image the FTs in a minimally invasive procedure for early detection of cancer. Our lab previously built a prototype benchtop FT endoscope with pseudowhite light imaging, multispectral fluorescence imaging and optical coherence tomography. This endoscope was approximately 0.9 mm in diameter, flexible and steerable in one direction. Several modifications have been made to create a falloposcope imaging system which is ready for clinical use. This new design includes a multilumen extrusion, a revised handle design, simplified lens design and redesigned subsystems resulting in improved mechanical characteristics, biocompatibility and portability while maintaining image quality. Additionally, these clinical endoscopes are single use, considerably less expensive and faster to build as compared to the prototype.

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Section: Discussionmentioning

confidence: 99%

Reengineering a falloposcope imaging system for clinical use

Kiekens

Romano

Galvez

et al. 2020

Transl Biophotonics

Self Cite

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“…Already, monolithic lens designs for fluorescence imaging and OCT microendoscopy have been shown 31 . We have previously demonstrated a 500µm diameter 3D-printed singlet with an excellent surface quality and DOF, but the optical performance was limited by the bulk scattering of the resin 32 . Recent activity in the 3D-printed lens field have explored the use of new resins more applicable to biomedical applications.…”

Section: Common Approachesmentioning

confidence: 99%

Comparison of micro-optic systems for close-focus microendoscopic applications

Galvez,

Hong,

Rocha

et al. 2024

Endoscopic Microscopy XIX

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To detect disease in organs with small lumens like the pancreas or fallopian tubes, where lumens may be collapsed or filled with mucus, cilia, or plicae, minimally invasive submillimeter endoscopes must meet unique optical requirements. They must provide a moderate angular field of view (AFOV), a close working distance (WD), and provide adequate resolution for the application. Additionally, when using miniature fiber bundles for image relay, the effect of the honeycomb pattern and potential fiber crosstalk must be considered. We compare the optical performance of a gradient refractive index (GRIN) singlet, a 3D-printed doublet, and a 3D-printed triplet, as well as discuss the consequences of fiber bundle use. We show that for our designs, both GRIN lenses and 3D printed aspheric lens systems can meet our application requirements, with to the ability to resolve less than 10µm at 10% contrast. The effect of fiber bundle crosstalk is shown to be negligible because of limited mode coupling in realistic manufactured fiber bundles.

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“…Recently, there has been interest in the implementation of 3D printed optics in endoscopy. [24][25][26] At the sub-mm size scale there are limited stock options for optical components, and custom systems can be expensive and time-consuming to manufacture with conventional fabrication techniques, making prototyping more difficult. Distal end optical systems comprised of multiple elements need to be assembled post-lens fabrication, thus the performance of the system has the potential to be affected by assembly errors.…”

Section: Distal End Optical System Designmentioning

confidence: 99%

Design of a 1.0mm multiphoton microscopy microendoscope

Adams,

Hong,

Valenzuela

et al. 2024

Endoscopic Microscopy XIX

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Early indicators of cancer manifest as cellular abnormalities that can be imaged via high resolution imaging modalities such as label-free Multiphoton Microscopy (MPM). Implementing MPM endoscopically can aid in the early diagnosis of cancer. We are developing a minimally invasive microendoscope system capable of simultaneous co-registered multiphoton imaging (two-and three-photon excited fluorescence, second and third harmonic generation) of the epithelial layer in small diameter ductal tissues via helical scanning of a 1.0 mm diameter endoscope distal end with a fixed focus. The endoscope working length is comprised of a stationary outer sheath housing a proximally driven endoscope distal optical system. The lenses are 0.5 mm in diameter and side viewing, requiring a novel optical design with power on the exit surface of the fold prism. Additive manufacturing (three-dimensional [3D] printing) opens significantly more possibilities for distal end microendoscope optical design. We present the design of the distal end outer sheath, housing, and optics, as well as an evaluation of the feasibility of 3D printed optics for a high numerical aperture (HNA) MPM microendoscope system. The selected distal end outer sheath meets flexibility, size, and optical requirements suitable for a first iteration lab prototype. The distal end housing was custom designed to be easily attached and removed from the proximal system and to ensure stable and consistent helical motion of the inner probe distal end when it is flexed and bent in manners needed for use in curved tissue lumens. We have also designed and manufactured (via two photon polymerization) multiple configurations of a 0.5 mm monolithic multi-element lens system containing an aspheric surface on the exit face of the prism and evaluated its optical performance.

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3D printed lens for depth of field imaging

Cited by 11 publications

References 10 publications

Reengineering a falloposcope imaging system for clinical use

Reengineering a falloposcope imaging system for clinical use

Comparison of micro-optic systems for close-focus microendoscopic applications

Design of a 1.0mm multiphoton microscopy microendoscope

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