3D printed matrix solid forms: Can the drug solubility and dose customisation affect their controlled release behaviour?

Santos, Juliana dos; Balbinot, Gabriela de Souza; Buchner, Silvio; Collares, Fabrício Mezzomo; Windbergs, Maike; Deon, Marion; Beck, Ruy Carlos Ruver

doi:10.1016/j.ijpx.2022.100153

Cited by 5 publications

(4 citation statements)

References 40 publications

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“…The PXRD patterns of HPMC, SD1, and SD2 exhibited no visible diffraction patterns but displayed the characteristic amorphous halo [ 55 , 56 ]. However, the physical mixtures of SD1 and SD2 showed specific peaks at 2θ in the range of 5–20°, indicating a crystalline content from DEX, as previously described in literature [ 52 , 53 ]. In Fig.…”

Section: Resultssupporting

confidence: 80%

See 1 more Smart Citation

Design of colon-targeted drug delivery of dexamethasone: Formulation and in vitro characterization of solid dispersions

Zaid Alkilani,

Omar,

Nasereddin

et al. 2024

Heliyon

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Section: Resultssupporting

confidence: 80%

“…3 C shows the PXRD patterns of HPMC, DEX-SDs, and their corresponding physical mixtures. Because DEX is known to have a crystalline structure [ 52 , 53 ], it is noteworthy that we did not conduct a PXRD study on it. Two characteristic peaks at 8° and 20° on the HPMC diffractogram agree with the previous study [ 54 ].…”

Section: Resultsmentioning

confidence: 99%

Design of colon-targeted drug delivery of dexamethasone: Formulation and in vitro characterization of solid dispersions

Zaid Alkilani,

Omar,

Nasereddin

et al. 2024

Heliyon

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“…Contemporary 3D printing technologies provide a versatile platform for preparing highly innovative personalized pharmaceutical dosage forms [26]. Moreover, 3D printing is a valuable technique especially for poorly water-soluble drugs, such as benzodiazepine derivatives, to overcome the challenges related to their formulation, and to enhance their oral bioavailability and therapeutic efficacy [39,40].…”

Section: Discussionmentioning

confidence: 99%

“…Three-dimensional (3D) printing is an emerging manufacturing technology with several applications in the pharmaceutical dosage form design [25]. Modern 3D printing methods enable the preparation of personalized drug delivery systems (DDSs) based on individual patient needs (i.e., specific doses or combinations of drugs) [26]. In addition, 3D printing enables the fabrication of sophisticated DDSs (such as controlled-release and multi-drug preparations) [27], thus improving the therapeutic efficacy of pharmaceuticals and enhancing patient compliance.…”

Section: Semi-solid Extrusion 3d Printing Of Functionalized Polyethyl...mentioning

confidence: 99%

Semi-solid extrusion 3D printing of functionalized polyethylene oxide gels loaded with 1,2,3-triazolo-1,4-benzodiazepine nanofibers and valine-modified motherwort (Leonurus cardiaca L.) dry extract

Botsula,

Kireyev,

Koshovyi

et al. 2024

SR: PS

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Anxiety disorders are the most prevalent psychiatric disorders and are associated with a high burden of illness. Combining synthetic and native-origin compounds in treating such disorders could provide true benefits in terms of therapeutic efficacy. In the present study, we combined triazolobenzodiazepine and motherwort (Leonurus cardiaca L.) dry extract for such applications. The aim. The aim of this study was to develop aqueous polyethylene oxide (PEO) composite gels loaded with 1,2,3-triazolo-1,4-benzodiazepine nanofibers and a valine-modified motherwort herb dry extract for semi-solid extrusion (SSE) 3D printing. The printability of such gels and the physicochemical properties of the final 3D-printed drug preparations were investigated. Materials and methods. A new drug substance, 1,2,3-triazolo-1,4-benzodiazepine (MA-253) was synthesized and used to formulate oleogels and electrospun nanofibers for 3D printing. The plant-origin dry extract was prepared from a motherwort tincture and valine. The aqueous PEO gels loaded with a synthetic drug (MA-253) containing nanofibers and a valine-modified motherwort extract were prepared and subsequently used in the SSE 3D printing experiments. The homogeneity, viscosity and 3D printability of composite PEO gels were verified. The phytochemical assay of flavonoids in the 3D-printed drug preparations was conducted with the European pharmacopoeia spectrophotometric method. Research results. Three experimental gel formulations loaded with 1,2,3-triazolo-1,4-benzodiazepine nanofibers and a valine-modified motherwort dry extract were developed and tested for the SSE 3D printing applications. The present three gels showed good SSE 3D printability without any significant printing flaws. The SSE 3D-printed lattices prepared from the aqueous PEO gels containing 100 mg/ml of motherwort extract showed the most promising 3D printing performance. The 3D-printed drug preparations were entirely dissolved in purified water (22±2 °C) within 20 minutes, thus suggesting their applicability in oral administration. Conclusions. Novel aqueous PEO gel formulations loaded with nanofibrous 1,2,3-triazolo-1,4-benzodiazepine nanofibers and valine-modified motherwort herb extract are feasible for pharmaceutical SSE 3D printing. The present composite PEO gels enable the preparation of printed oral immediate-release drug delivery systems for new triazolobenzodiazepine derivatives and a drug therapy supportive plant extract

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Three-dimensional (3D) printing in dental practice: Applications, areas of interest, and level of evidence

et al. 2023

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3D printed matrix solid forms: Can the drug solubility and dose customisation affect their controlled release behaviour?

Cited by 5 publications

References 40 publications

Design of colon-targeted drug delivery of dexamethasone: Formulation and in vitro characterization of solid dispersions

Design of colon-targeted drug delivery of dexamethasone: Formulation and in vitro characterization of solid dispersions

Semi-solid extrusion 3D printing of functionalized polyethylene oxide gels loaded with 1,2,3-triazolo-1,4-benzodiazepine nanofibers and valine-modified motherwort (Leonurus cardiaca L.) dry extract

Three-dimensional (3D) printing in dental practice: Applications, areas of interest, and level of evidence

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