3D printed microfluidic devices: a review focused on four fundamental manufacturing approaches and implications on the field of healthcare

Mehta, Viraj; Rath, Subha Narayan

doi:10.1007/s42242-020-00112-5

Cited by 121 publications

(106 citation statements)

References 175 publications

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“…Recently, 3D printing has been utilized to create microuidic devices for healthcare, chemistry, and engineering applications. [3][4][5] 3D printing is fast, simple, low cost, and can produce 3D structured polymer microchips that are resistant to swelling in solvents. [6][7][8] PDMS is known to swell in many organic solvents, which limits its application in micro-uidics.…”

Section: Introductionmentioning

confidence: 99%

Hydrophilic modification of SLA 3D printed droplet generators by photochemical grafting

et al. 2021

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Section: Introductionmentioning

confidence: 99%

Hydrophilic modification of SLA 3D printed droplet generators by photochemical grafting

et al. 2021

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“…It enables the creation of low-cost and rapid prototyping of microfluidic devices with intricate 3D designs, which can be readily adjusted at minimal additional effort [9]. Despite the current fabrication challenges [10,11], 3D printing for microfluidic device fabrication has been rapidly moving toward becoming the dominant microfluidic fabrication method for numerous biochemical and biomedical research projects [12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Recent Advances and Future Perspectives on Microfluidic Mix-and-Jet Sample Delivery Devices

2021

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The integration of the Gas Dynamic Virtual Nozzle (GDVN) and microfluidic technologies has proven to be a promising sample delivery solution for biomolecular imaging studies and has the potential to be transformative for a range of applications in physics, biology, and chemistry. Here, we review the recent advances in the emerging field of microfluidic mix-and-jet sample delivery devices for the study of biomolecular reaction dynamics. First, we introduce the key parameters and dimensionless numbers involved in their design and characterisation. Then we critically review the techniques used to fabricate these integrated devices and discuss their advantages and disadvantages. We then summarise the most common experimental methods used for the characterisation of both the mixing and jetting components. Finally, we discuss future perspectives on the emerging field of microfluidic mix-and-jet sample delivery devices. In summary, this review aims to introduce this exciting new topic to the wider microfluidics community and to help guide future research in the field.

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“…Considering these requirements, we reasoned that digital light projection (DLP) 3D printing, which uses UV or blue light to cure photocrosslinkable resins layer by layer [ 19 , 20 ], may facilitate SlipChip fabrication and allow for rapid prototyping. This additive method is quickly gaining popularity for fabricating small parts and microfluidic devices, because of both its high feature resolution and reproducibility and its rapid fabrication speed compared to traditional soft-lithography [ 3 , 21 , 22 , 23 ]. While 3D printing has not been reported previously for SlipChips, two of the four fabrication requirements are already met.…”

Section: Introductionmentioning

confidence: 99%

Rapid Fabrication by Digital Light Processing 3D Printing of a SlipChip with Movable Ports for Local Delivery to Ex Vivo Organ Cultures

2021

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SlipChips are two-part microfluidic devices that can be reconfigured to change fluidic pathways for a wide range of functions, including tissue stimulation. Currently, fabrication of these devices at the prototype stage requires a skilled microfluidic technician, e.g., for wet etching or alignment steps. In most cases, SlipChip functionality requires an optically clear, smooth, and flat surface that is fluorophilic and hydrophobic. Here, we tested digital light processing (DLP) 3D printing, which is rapid, reproducible, and easily shared, as a solution for fabrication of SlipChips at the prototype stage. As a case study, we sought to fabricate a SlipChip intended for local delivery to live tissue slices through a movable microfluidic port. The device was comprised of two multi-layer components: an enclosed channel with a delivery port and a culture chamber for tissue slices with a permeable support. Once the design was optimized, we demonstrated its function by locally delivering a chemical probe to slices of hydrogel and to living tissue with up to 120 µm spatial resolution. By establishing the design principles for 3D printing of SlipChip devices, this work will enhance the ability to rapidly prototype such devices at mid-scale levels of production.

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3D printed microfluidic devices: a review focused on four fundamental manufacturing approaches and implications on the field of healthcare

Cited by 121 publications

References 175 publications

Hydrophilic modification of SLA 3D printed droplet generators by photochemical grafting

Hydrophilic modification of SLA 3D printed droplet generators by photochemical grafting

Recent Advances and Future Perspectives on Microfluidic Mix-and-Jet Sample Delivery Devices

Rapid Fabrication by Digital Light Processing 3D Printing of a SlipChip with Movable Ports for Local Delivery to Ex Vivo Organ Cultures

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