3D‐Printed Microinjection Needle Arrays via a Hybrid DLP‐Direct Laser Writing Strategy (Adv. Mater. Technol. 5/2023)

Sarker, Sunandita; Colton, Adira; Wen, Ziteng; Xu, Xin; Erdi, Metecan; Jones, Anthony; Tubaldi, Eleonora; Walczak, Piotr; Janowski, Mirosław; Liang, Yajie; Sochol, Ryan D.

doi:10.1002/admt.202370021

Cited by 2 publications

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“…MAPs (5×5 mm 2 ) and artificial villi (2×2 cm 2 ) were fabricated by a multistep replica molding technique using DLP 3D‐printed molds ( Figure a). [ 44,45 ] Compared to other microfabrication methods, such as soft‐lithography, [ 46–48 ] laser cutting, [ 49 ] and electrical discharge machining, [ 50,51 ] replica molding using DLP 3D‐printed molds is a cost‐effective strategy to fabricate high‐aspect‐ratio soft microposts of arbitrary dimensions and with high fidelity (Figure 4c).…”

Section: Resultsmentioning

confidence: 99%

Villi Inspired Mechanical Interlocking for Intestinal Retentive Devices

et al. 2023

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Intestinal retentive devices have applications ranging from sustained oral drug delivery systems to indwelling ingestible medical devices. Current strategies to retain devices in the small intestine primarily focus on chemical anchoring using mucoadhesives or mechanical coupling using expandable devices or structures that pierce the intestinal epithelium. Here, the feasibility of intestinal retention using devices containing villi‐inspired structures that mechanically interlock with natural villi of the small intestine is evaluated. First the viability of mechanical interlocking as an intestinal retention strategy is estimated by estimating the resistance to peristaltic shear between simulated natural villi and devices with various micropost geometries and parameters. Simulations are validated in vitro by fabricating micropost array patches via multistep replica molding and performing lap‐shear tests to evaluate the interlocking performance of the fabricated microposts with artificial villi. Finally, the optimal material and design parameters of the patches that can successfully achieve retention in vivo are predicted. This study represents a proof‐of‐concept for the viability of micropost‐villi mechanical interlocking strategy to develop nonpenetrative multifunctional intestinal retentive devices for the future.

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Section: Resultsmentioning

confidence: 99%

Villi Inspired Mechanical Interlocking for Intestinal Retentive Devices

et al. 2023

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“…Direct laser writing (DLW) is a 3D printing technology that uses a focused laser beam to selectively cure and solidify a photosensitive resin, creating complex structures with sub‐1 µm resolution. [ 23 ] This technology has many potential applications in fields such as microelectronics, biomedicine, and microrobotics, [ 24–27 ] and has the potential to revolutionize the way we design and manufacture small‐scale devices and structures. One of the key advantages of DLW is its high resolution.…”

Section: Introductionmentioning

confidence: 99%

3D‐Printed Multi‐scale Fluidics for Liquid Metals

Smith,

Gesell,

Restaino

et al. 2023

Adv Materials Technologies

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Room‐temperature eutectic Gallium Indium (eGaIn)‐based devices offer stretchable, conductive, and reconfigurable properties for robotics, communications, and medicine. Microfluidics enables eGaIn device creation, but these typically have larger feature sizes. Recent three‐dimensional (3D) printing advancements, particularly direct laser writing (DLW), allow for sub‐100 µm microfluidic devices. However, interfacing DLW microfluidics with larger systems poses challenges in channel resist removal, eGaIn filling, and electrical integration, limiting micro‐scale liquid metal device application. This study introduces a multiscale, cost‐effective, three‐step process combining DLW‐fluidic microchannels with centimeter‐scale substrates made via stereolithography (SLA). It establishes a robust interface between independently printed materials and simplifies eGaIn filling in microfluidic channels as small as 50 µm, potentially enabling smaller liquid metal features. The research also presents eGaIn coils with 43–770 mΩ resistance and 2–4 nH inductance. This process facilitates low‐temperature, conductive, flexible interfaces for sensors, actuators, and circuits, and expands the range for size‐dependent properties of passive electronic components like resistors, capacitors, and inductors from liquid metal.

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3D‐Printed Microinjection Needle Arrays via a Hybrid DLP‐Direct Laser Writing Strategy (Adv. Mater. Technol. 5/2023)

Cited by 2 publications

References 0 publications

Villi Inspired Mechanical Interlocking for Intestinal Retentive Devices

Villi Inspired Mechanical Interlocking for Intestinal Retentive Devices

3D‐Printed Multi‐scale Fluidics for Liquid Metals

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