3D printed microneedles for insulin skin delivery

Pere, Cristiane Patricia Pissinato; Economidou, Sophia N.; Lall, Gurprit S.; Ziraud, Clémentine; Boateng, Joshua; Alexander, Bruce D.; Lamprou, Dimitrios A.; Douroumis, Dennis

doi:10.1016/j.ijpharm.2018.03.031

Cited by 279 publications

(186 citation statements)

References 37 publications

Supporting

Mentioning

181

Contrasting

Unclassified

Order By: Relevance

“…Figure 1F is the optical microscopic image of the GelMA MN patch, which showed an 11 × 11 array of uniformly aligned MNs fixed on a 1 cm × 1 cm patch to support sufficient ISF extraction for later analysis. The most commonly used techniques to manufacture MNs with different shapes and sizes include micromolding,30 lithography,31 laser cutting,32 3D printing,33 and wet or dry etching 34. In the present work, we used a polydimethylsiloxane (PDMS) mold with a predesigned shape and size to manufacture the MN patches.…”

Section: Figurementioning

confidence: 99%

Gelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid

Zhu

Zhou

Kim

et al. 2020

Small

141

130

View full text Add to dashboard Cite

The extraction of interstitial fluid (ISF) from skin using microneedles (MNs) has attracted growing interest in recent years due to its potential for minimally invasive diagnostics and biosensors. ISF collection by absorption into a hydrogel MN patch is a promising way that requires the materials to have outstanding swelling ability. Here, a gelatin methacryloyl (GelMA) patch is developed with an 11 × 11 array of MNs for minimally invasive sampling of ISF. The properties of the patch can be tuned by altering the concentration of the GelMA prepolymer and the crosslinking time; patches are created with swelling ratios between 293% and 423% and compressive moduli between 3.34 MPa and 7.23 MPa. The optimized GelMA MN patch demonstrates efficient extraction of ISF. Furthermore, it efficiently and quantitatively detects glucose and vancomycin in ISF in an in vivo study. This minimally invasive approach of extracting ISF with a GelMA MN patch has the potential to complement blood sampling for the monitoring of target molecules from patients.

show abstract

Section: Figurementioning

confidence: 99%

Gelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid

Zhu

Zhou

Kim

et al. 2020

Small

141

130

View full text Add to dashboard Cite

show abstract

“…CAE files are digitalized representations of conical MNs. Conical MNs are produced in MicroChem (SU-8 photoresist) via UV exposure 21,47,48 (Fig. 1A).…”

Section: Materials Polyvinyl Pyrrolidone K-30 (Pvp K-30) Was Kindly mentioning

confidence: 99%

Characterization and Pharmacological Evaluation of Anti-Cellulite Herbal Product(s) Encapsulated in 3D-Fabricated Polymeric Microneedles

Amer

Elosaily

Bakr

et al. 2020

Sci Rep

View full text Add to dashboard Cite

Skin health is vital for a healthy body. Herbal remedies have long been used for skin care, and their global use has tremendously increased over the past three decades. Although cellulite is seen as a normal condition by the medical community, it is considered a serious cosmetic concern for most affected women. Many topical anti-cellulite creams are available on the market, but unfortunately, their efficacy has not been proven scientifically. Microneedles (MNs) represent a new approach to enhance the permeation of loaded medication through the skin. In this study, the anti-cellulite effects of Vitex agnus-castus and Tamarindus indica extracts were compared using safe and effective polymeric MNs. This delivery system offers a painless alternative to the combined treatment strategy of microneedling devices and anti-cellulite products. The selected standardized extracts were evaluated for their mineral, phenolic and flavonoid contents, which are correlated to a promising antioxidant effect, as demonstrated by an in vitro radical scavenging activity assay. 3D-printing techniques were chosen for fabrication of a micromold, which is inexpensive for mass production. To ensure that MNs were sufficiently strong to perforate the skin without breaking, axial failure force was measured using a micro-mechanical test machine. The anticellulite effects of MNs were assessed using an in vivo dietinduced obesity guinea pig model. Skin properties, histopathology and inflammatory markers were examined. MNs loaded with plant extracts were statistically comparable in normalizing the oxidative state and reducing inflammation, while myeloperoxidase levels were more significantly reduced by T. indica than by V. agnus-castus. This novel delivery system opens the door for new transdermal strategies for cellulite management. The skin is a chief barrier that provides protection for the human body. The outermost layer of the epidermis (stratum corneum, SC) is mainly responsible for this barrier property. Cellulite is a skin condition that affects up to 90% of women over 20 years of age and only 2% of men. It includes changes in skin appearance, with an orange-peel-like texture (mostly on the hips and buttocks) due to the expansion of fat lobules out of their connective frame and into the dermis 1-3. Cellulite is a pathologically complicated condition that is associated with decreased microcirculation, oedema, overgrowth of adipocytes, oxidative stress, continuous inflammation, and changes in the extracellular matrix 4,5. Some pharmaceutical products can treat cellulite by increasing the microvascular flow, inducing lipolysis, restoring dermis and connective tissue structures, and preventing

show abstract

“…The study also showed the degradability of polylactic acid (a renewable, biodegradable, and thermoplastic polymer) in the skin, leading to the drug release (Luzuriaga et al 2018). Pere et al (2018) also fabricated biocompatible polymeric microneedle patches for insulin skin delivery. Using the SLA method, a biocompatible resin was photopolymerized to make microneedles of cone and pyramid geometries, followed by IJ print coating of insulin formulations.…”

Section: Microneedlesmentioning

confidence: 91%

Pharmaceutical applications of 3D printing technology: current understanding and future perspectives

Park

Choi

Moon

et al. 2018

J. Pharm. Investig.

View full text Add to dashboard Cite

Three-dimensional printing (3DP) technology allows the fabrication of 3D objects with various geometrics in a layer-bylayer process. Some advantages of 3DP methods over the conventional manufacturing processes include the customization of medicines with individually adjusted doses, the ability to fabricate the sophisticated and complex solid dosage forms, on-demand manufacturing, and cost-effectiveness. Furthermore, recent years have seen an increasing interest in applying 3DP technology to the pharmaceutical manufacturing of drug products and development of various drug delivery systems. However, although 3DP technology exhibits many potential medical and economic benefits, there are also some technical and regulatory challenges restricting the wide applications of 3DP technology to pharmaceutical products. Accordingly, continuous innovation and refinement in 3DP methods are needed to overcome the current limitations and facilitate patientspecific health care with on-demand tailored medications in the future. This review introduces some 3DP techniques suitable for pharmaceutical manufacturing and also their applications to the development of drug dosage forms, indicating the feasibility of this technology in regular commercial production.

show abstract

3D printed microneedles for insulin skin delivery

Cited by 279 publications

References 37 publications

Gelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid

Gelatin Methacryloyl Microneedle Patches for Minimally Invasive Extraction of Skin Interstitial Fluid

Characterization and Pharmacological Evaluation of Anti-Cellulite Herbal Product(s) Encapsulated in 3D-Fabricated Polymeric Microneedles

Pharmaceutical applications of 3D printing technology: current understanding and future perspectives

Contact Info

Product

Resources

About