3D-Printed Microrobots: Translational Challenges

Sarabi, Misagh Rezapour; Karagoz, Ahmet Agah; Yetisen, Ali K.

doi:10.3390/mi14061099

Cited by 4 publications

(2 citation statements)

References 33 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…When compared to conventional manufacturing techniques, 3D printing stands out for its cost-effectiveness, swift adaptability for design alterations, and its capacity to utilize an extensive array of materials, spanning from metals and polymers to bioinks and composites. The accessibility and consistency of 3D printing have firmly established it as the emerging method of choice for microrobot fabrication, even for individuals with limited expertise in micromanufacturing [21].…”

Section: Background On 3d Printing Technologymentioning

confidence: 99%

Empowering Precision Medicine: The Impact of 3D Printing on Personalized Therapeutic

Alzoubi,

Aljabali,

Tambuwala

2023

AAPS PharmSciTech

View full text Add to dashboard Cite

This review explores recent advancements and applications of 3D printing in healthcare, with a focus on personalized medicine, tissue engineering, and medical device production. It also assesses economic, environmental, and ethical considerations. In our review of the literature, we employed a comprehensive search strategy, utilizing well-known databases like PubMed and Google Scholar. Our chosen keywords encompassed essential topics, including 3D printing, personalized medicine, nanotechnology, and related areas. We first screened article titles and abstracts and then conducted a detailed examination of selected articles without imposing any date limitations. The articles selected for inclusion, comprising research studies, clinical investigations, and expert opinions, underwent a meticulous quality assessment. This methodology ensured the incorporation of high-quality sources, contributing to a robust exploration of the role of 3D printing in the realm of healthcare. The review highlights 3D printing's potential in healthcare, including customized drug delivery systems, patient-specific implants, prosthetics, and biofabrication of organs. These innovations have significantly improved patient outcomes. Integration of nanotechnology has enhanced drug delivery precision and biocompatibility. 3D printing also demonstrates cost-effectiveness and sustainability through optimized material usage and recycling. The healthcare sector has witnessed remarkable progress through 3D printing, promoting a patient-centric approach. From personalized implants to radiation shielding and drug delivery systems, 3D printing offers tailored solutions. Its transformative applications, coupled with economic viability and sustainability, have the potential to revolutionize healthcare. Addressing material biocompatibility, standardization, and ethical concerns is essential for responsible adoption. Graphical Abstract

show abstract

Section: Background On 3d Printing Technologymentioning

confidence: 99%

Empowering Precision Medicine: The Impact of 3D Printing on Personalized Therapeutic

Alzoubi,

Aljabali,

Tambuwala

2023

AAPS PharmSciTech

View full text Add to dashboard Cite

show abstract

“…The model can be used to find efficient procedures for MN fabrication prior to actual production, saving materials and resources. 27 In another example, drug diffusion from a polymeric MN patch was simulated, using surface erosion theory and Fick's law. 28 The model allows users to optimize the MN design without fabricating the MN patch.…”

mentioning

confidence: 99%

Prediction of drug permeation through microneedled skin by machine learning

Yuan

Han

Yap³

et al. 2023

Bioengineering & Transla Med

View full text Add to dashboard Cite

Stratum corneum is the outermost layer of the skin preventing external substances from entering human body. Microneedles (MNs) are sharp protrusions of a few hundred microns in length, which can penetrate the stratum corneum to facilitate drug permeation through skin. To determine the amount of drug delivered through skin, in vitro drug permeation testing is commonly used, but the testing is costly and time‐consuming. To address this issue, machine learning methods were employed to predict drug permeation through the skin, circumventing the need of conducting skin permeation experiments. By comparing the experimental data and simulated results, it was found extreme gradient boosting (XGBoost) was the best among the four simulation methods. It was also found that drug loading, permeation time, and MN surface area were critical parameters in the models. In conclusion, machine learning is useful to predict drug permeation profiles for MN‐facilitated transdermal drug delivery.

show abstract

Advanced Biomimetic and Biohybrid Magnetic Micro/Nano‐Machines

Murali,

Das,

Yadav

et al. 2024

Adv Materials Technologies

View full text Add to dashboard Cite

Biomimetic and biohybrid micro/nano‐structures involve the replication and creation of technologies, structures, and materials based on biological systems at the micrometer and nanometer scale. These strategies harness the natural biological principles to develop innovative treatment methods and advanced microstructure devices for noninvasive therapies. In this study, a detailed overview of fabrication processes, magnetically assisted locomotive techniques, and potential applications of biomimetic and biohybrid micro/nano‐machines are presented. The latest advancements in magnetically actuated biomimetic structures, such as annelid‐worm‐like microswimmers, jellyfish‐shaped microparticles, fish‐shaped microswimmers, and walnut‐shaped micromotors are explored. Additionally, the magnetic biohybrid systems, including sunflower seed‐based micro‐perforators, nanomotors extracted from the bamboo stem, sperm cell‐based micromotors, bacteria‐based robots, scaffold‐based microrobots, DNA‐based micromotors, microalgae‐based microswimmers, and red blood cell‐based microswimmers are also examined. A thorough investigation of the magnetically assisted locomotive behavior of these microstructure devices in biological Newtonian fluids, featuring cork‐screw motion, undulatory motion, surface wrinkling motion, traveling wave‐like motion, and ciliary stroke motion is discussed. Furthermore, unprecedented and innovative treatment methods developed using these minuscule devices such as cervical cancer treatment using tetrapod hybrid sperm micromotors, tissue regeneration using silk fibroin protein‐based magnetic microscale scaffolds, and doxorubicin drug delivery using mushroom‐based microrobots is extensively presented.

show abstract

3D-Printed Microrobots: Translational Challenges

Cited by 4 publications

References 33 publications

Empowering Precision Medicine: The Impact of 3D Printing on Personalized Therapeutic

Empowering Precision Medicine: The Impact of 3D Printing on Personalized Therapeutic

Prediction of drug permeation through microneedled skin by machine learning

Advanced Biomimetic and Biohybrid Magnetic Micro/Nano‐Machines

Contact Info

Product

Resources

About