3D-Printed Multifunctional Polyetheretherketone Bone Scaffold for Multimodal Treatment of Osteosarcoma and Osteomyelitis

Abstract

In this work, we developed the first 3D-printed polyetheretherketone (PEEK)-based bone scaffold with multi-functions targeting challenging bone diseases such as osteosarcoma and osteomyelitis. A 3D-printed PEEK/graphene nanocomposite scaffold was deposited with a drug-laden (antibiotics and/or anti-cancer drugs) hydroxyapatite coating. The graphene nanosheets within the scaffold served as effective photothermal agents that endowed the scaffold with on-demand photothermal conversion function under near-infrared laser irradiation. The bioactive hydroxyapatite coating significantly boosted the stem cell proliferation in vitro and promoted new bone growth in vivo. The presence of antibiotics and anti-cancer drugs enabled eradication of drug-resistant bacteria and ablation of osteosarcoma cancer cells, the treatment efficacy of which can be further enhanced by on-demand laser-induced heating. The promising results demonstrate the strong potential of our multi-functional scaffold in applications such as bone defect repair and multimodal treatment of osteosarcoma and osteomyelitis.

Hydroxygenkwanin suppresses proliferation, invasion and migration of osteosarcoma cells via the miR‑320a/SOX9 axis

“…Various concentrations (0, 10, 20, 40 and 60 µmol/l) of HGK were applied to treat hFOB 1.19 cells to test the safety of the drug. In addition, MG-63 and U2OS cells were also treated with various concentrations of HGK (10,20,40 and 60 µmol/l) for 48 h, and assigned as the treatment groups. Moreover, MG-63 and U2OS cells as well as hFOB 1.19 cells received 0 µmol/l HGK and were assigned as the control groups.…”

“…In recent years, with the development of tissue engineering, increasing attention has been paid to the development of bone substitutes with custom-made microarchitecture and physicomechanical properties comparable to native bone, such as bioactive three-dimensional (3D) porous polymer or ceramic scaffolds or its conjugated forms, which can mimic the host tissue to facilitate the transferring of nutrients to ensure defective bone restoration (7)(8)(9). Moreover, 3D-printed multifunctional polyetheretherketone bone scaffold was widely applied in the multimodal treatment of osteosarcoma and osteomyelitis (10). clinical results reveal that the efficacy of current chemotherapy drugs in patients with metastatic osteosarcoma is insufficient (11).…”

Therapeutic application of hydrogels for bone-related diseases

“…It is worth mentioning that some macromolecular nanomaterials composed of nanoparticles (such as nanosheets, nanotubes, mesoporous materials, etc.) are often used as nanoplatforms to carry drugs to treat diseases ( Yan J. et al, 2021 ; Wang Y.-C. et al, 2021 ; Zhu et al, 2021 ). To date, nanomaterials have been widely used in various fields of medical treatment ( Zhu et al, 2018 , 2019 ).…”

Microenvironment-responsive electrocution of tumor and bacteria by implants modified with degenerate semiconductor film

“…Resect the malignant lesions through surgery is the first treatment option for tumors without extensive metastatic lesions, while palliative therapy is the optimal choice for terminal cancer [ 2 ]. Implants are widely used in both cases, they can fill the surgical site resulting from the tumor resection surgery [ 3 , 4 ]. Or as a stent to alleviate malignant obstruction in the palliative treatment [ 5 , 6 ].…”