3D-Printed Pacifier-Shaped Mouthpiece for fMRI-Compatible Gustometers

Tord, David Munoz; Coppin, Géraldine; Pool, Eva; Mermoud, Christophe; Pataky, Zoltan; Sander, David; Delplanque, Sylvain

doi:10.1523/eneuro.0208-21.2021

Cited by 4 publications

(9 citation statements)

References 35 publications

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“…In a nutshell, a 3D-printed paci er-shape fMRI mouthpiece paired with a gustometer was used to deliver liquids while participants were lying down. As demonstrated in Muñoz-Tord et al [10], this allows a precise, reliable and comfortable liquid delivery. The collection of the responses was controlled by a computer running MATLAB (version R2015a; MathWorks, Natick, USA).…”

Section: Taste Stimuli and Presentationmentioning

confidence: 85%

“…The data reported here were acquired in the context of a larger study, components of which have been [10] and will be reported separately. More precisely, we conducted this randomized, single-centre, double-blind, placebo-controlled, parallel group, prospective clinical trial from March 7, 2018, through March 18, 2020, in the Geneva University Hospitals (Switzerland), i.e.…”

Section: Trial Overviewmentioning

confidence: 99%

“…fMRI Data Acquisition Parameters. Acquisition parameters were identical to the ones described in Muñoz-Tord et al [10]. The neuroimaging data were acquired on a 3-Tesla MRI system (Magnetom Tim Trio, Siemens Medical Solutions) supplied with a 32-channel head coil following a gradient echo (GRE) sequence to record data acquisition BOLD signal.…”

Section: Statistical Analysis Behavioral and Metabolic Datamentioning

confidence: 99%

“…Preprocessing. As in Muñoz-Tord et al [10], we created a pipeline optimized for the preprocessing of our neuroimaging data. More speci cally, we combined the Functional Magnetic Resonance Imaging of the Brain (FMRIB) Software Library (FSL, version 4.1) [19] with the Advanced Normalization Tools (ANTS, version 2.1) [20].…”

Section: Statistical Analysis Behavioral and Metabolic Datamentioning

confidence: 99%

“…The apparatus used to deliver the liquids in the scanner has been described in Muñoz-Tord et al [10]. In a nutshell, a 3D-printed paci er-shape fMRI mouthpiece paired with a gustometer was used to deliver liquids while participants were lying down.…”

Section: Taste Stimuli and Presentationmentioning

confidence: 99%

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Does GLP-1 receptor agonist liraglutide alter food-related sensory pleasure in patients with obesity? A randomized controlled trial

Coppin,

David,

Pool

et al. 2022

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Background/Objectives: Obesity is a complex condition and the mechanisms involved in weight gain and loss are poorly understood. Liraglutide, a GLP-1 receptor agonist, has been demonstrated to successfully promote weight loss in patients with obesity (OB). Yet, it is unclear whether the observed weight loss is driven by an alteration of food reward processing. Here we investigated the effects of liraglutide on cerebral correlates of food-related sensory pleasure in OB. Subjects/Methods: This study was a randomized, single-centre, double-blind, placebo-controlled, parallel group, prospective clinical trial. 73 patients with OB and without diabetes were randomly assigned (1:1) to receive liraglutide 3.0 mg (37.40±11.18 years old, BMI = 35.89 kg ±3.01) or placebo (40.04±14.10 years old, BMI = 34.88 kg ±2.87) subcutaneously once daily, for 16 weeks. They also followed a multidisciplinary weight loss program. Interventions/Methods: We investigated sensory pleasure during food consumption (i.e., “liking”). Participants reported their hedonic experience while consuming a high-calorie food (milkshake) and a tasteless solution. The solutions were administered inside the scanner with a Magnetic Resonance Imaging (MRI)-compatible gustometer to assess neural responses during consumption. The same procedure was repeated for pre- and post-intervention sessions. Results: The liraglutide group lost more weight (BMI post-pre = - 3.19 kg/m2 ±1.28) than the placebo group (BMI post-pre = - 0.60 kg/m2 ±1.26). The sensory pleasure during food reward consumption was associated with the activation of the ventromedial prefrontal cortex (vmPFC) and the amygdala. We did not find any statistically significant difference in the liraglutide group between the pre and post sessions, neither at a subjective level nor at a neural level in terms of reactivity of the vmPFC to the milkshake.Conclusions: These results suggest that liraglutide leads to weight loss without self-report or neural evidence supporting a concomitant reduction of food-related sensory pleasure in patients with from obesity.

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Section: Taste Stimuli and Presentationmentioning

confidence: 85%

Section: Trial Overviewmentioning

confidence: 99%

Section: Statistical Analysis Behavioral and Metabolic Datamentioning

confidence: 99%