3D Printed Scaffolds for Wound Healing and Tissue Regeneration

Tabriz, Atabak Ghanizadeh; Douroumis, Dennis; Boateng, Joshua

doi:10.1002/9781119433316.ch17

Cited by 17 publications

(19 citation statements)

References 51 publications

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“…Drop-on-demand (DOD) is the most established inkjet-based bioprinting technology and is sub-categorized into thermal, piezoelectric, and electromagnetic DOD, which each share a similar printing mechanism [ 113 , 114 ]. The printing process consists of two phases: (1) the dispensing of bioink droplets to specific locations on the substrate; and (2) the interaction between the bioink droplets and substrate upon contact (crosslinking and gelation).…”

Section: Three-dimensional Bioprinting Approaches To Aid Wound Repmentioning

confidence: 99%

Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers

et al. 2020

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Diabetes mellitus (DM) is a chronic metabolic disease with increasing prevalence worldwide. Diabetic foot ulcers (DFUs) are a serious complication of DM. It is estimated that 15–25% of DM patients develop DFU at least once in their lifetime. The lack of effective wound dressings and targeted therapy for DFUs often results in prolonged hospitalization and amputations. As the incidence of DM is projected to rise, the demand for specialized DFU wound management will continue to increase. Hence, it is of great interest to improve and develop effective DFU-specific wound dressings and therapies. In the last decade, 3D bioprinting technology has made a great contribution to the healthcare sector, with the development of personalized prosthetics, implants, and bioengineered tissues. In this review, we discuss the challenges faced in DFU wound management and how 3D bioprinting technology can be applied to advance current treatment methods, such as biomanufacturing of composite 3D human skin substitutes for skin grafting and the development of DFU-appropriate wound dressings. Future co-development of 3D bioprinting technologies with novel treatment approaches to mitigate DFU-specific pathophysiological challenges will be key to limiting the healthcare burden associated with the increasing prevalence of DM.

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Section: Three-dimensional Bioprinting Approaches To Aid Wound Repmentioning

confidence: 99%

Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers

et al. 2020

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“…Each 3D printing method has a unique set of tradeoffs in resolution, cost-efficiency, biocompatibility, and output volume, enabling the use of 3D printing in a wide range of applications ( Bakhshinejad and D'souza, 2015 ; Park et al., 2015 ). The ability to use biomaterials in 3D printing processes ( Chia and Wu, 2015 ), along with microscale and nanoscale 3D printing ( You et al., 2018 ), can enable the fabrication of a wide range of laboratory instruments for clinical and point-of-care applications ( Aimar et al., 2019 ; Amin et al., 2016b ; Douroumis, 2019 ; Knowlton et al., 2015c ; Yenilmez et al., 2016a ), including organ-on-a-chip devices ( Jain et al., 2020 ; Knowlton and Tasoglu, 2016 ; Knowlton et al., 2016b , 2016c ), tissue engineering ( Knowlton et al., 2018 ; Sears et al., 2016 ; Zhang et al., 2019 ), wound healing ( Joseph et al., 2019 ; Tabriz et al., 2020 ), fertility and embryology research ( Kanakasabapathy et al., 2019 ; Knowlton et al., 2015d ; Potluri et al., 2018 ), cancer research ( Knowlton et al., 2015a , 2016a ), stem cell research ( Javaid and Haleem, 2020 ; Tasoglu and Demirci, 2013 ), and circulating tumor cell isolation ( Chen et al., 2020 ).…”

Section: Introductionmentioning

confidence: 99%

3D-printed microneedles in biomedical applications

et al. 2021

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Conventional needle technologies can be advanced with emerging nano-and micro-fabrication methods to fabricate microneedles. Nano-/micro-fabricated microneedles seek to mitigate penetration pain and tissue damage, as well as providing accurately controlled robust channels for administrating bioagents and collecting body fluids. Here, design and 3D printing strategies of microneedles are discussed with emerging applications in biomedical devices and healthcare technologies. 3D printing offers customization, cost-efficiency, a rapid turnaround time between design iterations, and enhanced accessibility. Increasing the printing resolution, the accuracy of the features, and the accessibility of low-cost raw printing materials have empowered 3D printing to be utilized for the fabrication of microneedle platforms. The development of 3D-printed microneedles has enabled the evolution of pain-free controlled release drug delivery systems, devices for extracting fluids from the cutaneous tissue, biosignal acquisition, and point-of-care diagnostic devices in personalized medicine.

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“…Nevertheless, natural polymers are often challenging for this approach [10]. In comparison with conventional methods, 3-D printing allows for the fabrication of flexible, repeatable, personalized, and anatomically fitting structures with design morphology and composition as well as with high complexity [11,12]. Advances in 3D printing technology have enabled 3D fabricating of functional scaffolds for tissues from both natural and synthetic biocompatible materials, cells, and cell-support materials.…”

Section: Introductionmentioning

confidence: 99%

3D Printing of Thermoresponsive Hydrogel Laden with an Antimicrobial Agent towards Wound Healing Applications

et al. 2021

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Thermoresponsive hydrogel-based wound dressings with an incorporated antimicrobial agent can be fabricated employing 3D printing technology. A novel printable ink containing poly(N-isopropylacrylamide) (PNIPAAm) precursors, sodium alginate (ALG), methylcellulose (MC) that is laden with a mixture of octenidine dihydrochloride and 2-phenoxyethanol (Octenisept®, OCT) possess accurate printability and shape fidelity. This study also provides the protocol of ink’s use for the 3D printing of hydrogel scaffolds. The hydrogel’s physicochemical properties and drug release profiles from the hydrogel specimens to the external solution have been determined at two temperatures (20 and 37 °C). The release test showed a sustained OCT delivery into ultrapure water and the PBS solution. The temperature-responsive hydrogel exhibited antimicrobial activity against Staphylococcus aureus, Candida albicans, and Pseudomonas aeruginosa and demonstrated non-cytotoxicity towards fibroblasts. The thermoresponsive behavior along with biocompatibility, antimicrobial activity, and controlled drug release make this hydrogel a promising class of materials for wound dressing applications.

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3D Printed Scaffolds for Wound Healing and Tissue Regeneration

Cited by 17 publications

References 51 publications

Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers

Application of 3D Bioprinting Technologies to the Management and Treatment of Diabetic Foot Ulcers

3D-printed microneedles in biomedical applications

3D Printing of Thermoresponsive Hydrogel Laden with an Antimicrobial Agent towards Wound Healing Applications

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