3D-printed stenotic aortic valve model to simulate physiology before, during, and after transcatheter aortic valve implantation

Zelis, Jo M.; Meiburg, Roel; Roijen, Jorn J.D.; Janssens, K.L.P.M.; Veer, Marcel van ’t; Pijls, Nico H.J.; Johnson, Nils P.; Vosse, Frans N. van de; Tonino, Pim A.L.; Rutten, Marcel

doi:10.1016/j.ijcard.2020.04.087

Cited by 9 publications

(6 citation statements)

References 4 publications

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“…Zelis et al wanted to compare custom 3DP silicon valvular models to actual patient pressure gradients pre- and post-transcatheter aortic valve implantation (TAVI) when placed in a model of a circulatory system. After measuring the replicated pre- and post-TAVI pressure gradients, they found that the measurement prior to the intervention was underrepresented in the 3DP model (35.1 ± 0.6 mmHg as compared to 45.3 ± 1.5 mmHg) but resembled the patient gradient in the post-intervention measurement (3.7 ± 0.7 mmHg as compared to 6.7 ± 2.3 mmHg) [ 18 ].…”

Section: Discipline Specific Applicationsmentioning

confidence: 99%

The Role of 3D Printing in Planning Complex Medical Procedures and Training of Medical Professionals—Cross-Sectional Multispecialty Review

Meyer-Szary

Luis

Mikulski

et al. 2022

IJERPH

108

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Medicine is a rapidly-evolving discipline, with progress picking up pace with each passing decade. This constant evolution results in the introduction of new tools and methods, which in turn occasionally leads to paradigm shifts across the affected medical fields. The following review attempts to showcase how 3D printing has begun to reshape and improve processes across various medical specialties and where it has the potential to make a significant impact. The current state-of-the-art, as well as real-life clinical applications of 3D printing, are reflected in the perspectives of specialists practicing in the selected disciplines, with a focus on pre-procedural planning, simulation (rehearsal) of non-routine procedures, and on medical education and training. A review of the latest multidisciplinary literature on the subject offers a general summary of the advances enabled by 3D printing. Numerous advantages and applications were found, such as gaining better insight into patient-specific anatomy, better pre-operative planning, mock simulated surgeries, simulation-based training and education, development of surgical guides and other tools, patient-specific implants, bioprinted organs or structures, and counseling of patients. It was evident that pre-procedural planning and rehearsing of unusual or difficult procedures and training of medical professionals in these procedures are extremely useful and transformative.

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Section: Discipline Specific Applicationsmentioning

confidence: 99%

The Role of 3D Printing in Planning Complex Medical Procedures and Training of Medical Professionals—Cross-Sectional Multispecialty Review

Meyer-Szary

Luis

Mikulski

et al. 2022

IJERPH

108

View full text Add to dashboard Cite

show abstract

“…In addition to this, personalized medical strategies using 3D printing not only make complex surgeries repeatable but also improve patient safety and the effectiveness of treatment. Zelis et al [39] created a model of a narrowed aortic valve using 3D printing technology. They achieved good surgical results through preoperative evaluation, simulation, intraoperative guidance, and postoperative evaluations.…”

Section: Training and Surgical Planningmentioning

confidence: 99%

A Review on the Full Chain Application of 3D Printing Technology in Precision Medicine

Zeng

et al. 2023

Processes

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Personalized precision medicine is a new direction for medical development, and advanced manufacturing technology can provide effective support for the development of personalized precision medicine. Based on the layered accumulation manufacturing principle, 3D printing technology has unique advantages in personalized rapid manufacturing, and can form complex geometric shape parts at low cost and high efficiency. This article introduces the application progress of 3D printing technology in medical models, surgical navigation templates, invisible aligners, and human implants, analyzes their advantages and limitations, and provides an outlook for the development trend of 3D printing technology in precision medicine.

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“…Data showed that 3D printed aortic valves effectively simulated hemodynamics and pressure gradients, which were predicted accurately. However, the study concluded that further refinement of the model and the addition of calcification are required to improve [143]. A study has fabricated a triple-layered human alveolar lung model consisting of fibroblast, endothelial, and lung epithelial cells using DOD 3D printing technology.…”

Section: D Printing and In Vitro Cancer Modelsmentioning

confidence: 99%

Three-Dimensional (3D) Printing in Cancer Therapy and Diagnostics: Current Status and Future Perspectives

Safhi

2022

Pharmaceuticals

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Three-dimensional (3D) printing is a technique where the products are printed layer-by-layer via a series of cross-sectional slices with the exact deposition of different cell types and biomaterials based on computer-aided design software. Three-dimensional printing can be divided into several approaches, such as extrusion-based printing, laser-induced forward transfer-based printing systems, and so on. Bio-ink is a crucial tool necessary for the fabrication of the 3D construct of living tissue in order to mimic the native tissue/cells using 3D printing technology. The formation of 3D software helps in the development of novel drug delivery systems with drug screening potential, as well as 3D constructs of tumor models. Additionally, several complex structures of inner tissues like stroma and channels of different sizes are printed through 3D printing techniques. Three-dimensional printing technology could also be used to develop therapy training simulators for educational purposes so that learners can practice complex surgical procedures. The fabrication of implantable medical devices using 3D printing technology with less risk of infections is receiving increased attention recently. A Cancer-on-a-chip is a microfluidic device that recreates tumor physiology and allows for a continuous supply of nutrients or therapeutic compounds. In this review, based on the recent literature, we have discussed various printing methods for 3D printing and types of bio-inks, and provided information on how 3D printing plays a crucial role in cancer management.

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3D-printed stenotic aortic valve model to simulate physiology before, during, and after transcatheter aortic valve implantation

Cited by 9 publications

References 4 publications

The Role of 3D Printing in Planning Complex Medical Procedures and Training of Medical Professionals—Cross-Sectional Multispecialty Review

The Role of 3D Printing in Planning Complex Medical Procedures and Training of Medical Professionals—Cross-Sectional Multispecialty Review

A Review on the Full Chain Application of 3D Printing Technology in Precision Medicine

Three-Dimensional (3D) Printing in Cancer Therapy and Diagnostics: Current Status and Future Perspectives

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