3D Printed Sugar‐Sensing Hydrogels

Bruen, Danielle; Delaney, Colm; Chung, Johnson; Ruberu, Kalani; Wallace, Gordon G.; Diamond, Dermot; Florea, Larisa

doi:10.1002/marc.201900610

Cited by 8 publications

(9 citation statements)

References 30 publications

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“…Generally, T gel in such a range is fast enough to achieve successful 3D printing. [50,51] Figure 5c further shows that, upon exposing the PTH precursor to the intermittent light irradiation, the increase of G' and G" is only observed when the visible light is on. However, no change is found in these two parameters without visible light irradiation.…”

Section: D Printing Of Pthsmentioning

confidence: 87%

Bifunctional Phenol‐Enabled Sequential Polymerization Strategy for Printable Tough Hydrogels

Wei

Zhang

et al. 2022

Macromol. Rapid Commun.

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Hydrogels are promising material candidates in engineering soft robotics, mechanical sensors, biomimetic regenerative medicine, etc. However, developing multinetwork hydrogels with high mechanical properties and excellent printability are still challenging. Here, a bifunctional phenol‐enabled sequential polymerization (BPSP) strategy is reported to fabricate high‐performance multinetwork hydrogels under the orthogonal catalysis of efficient ruthenium photochemistry. Benefiting from this bifunctional design, phenols can sequentially polymerize with typical monomers and themselves to fabricate various phenol‐containing polymers (Ph‐Ps) and Ph‐Ps‐based multinetwork tough hydrogels, respectively. The as‐prepared hydrogels have maximum stress of 0.75 MPa and toughness of 2.2 MJ m–3 under the critical strain of 800%. These property parameters are a maximum of 16 times higher than those of the phenol‐postmodified and phenol‐free hydrogels. Moreover, the rapid coupling polymerization of phenols can shorten the gelation times of hydrogels to as low as ≈4 s, which enables its printable property for customizable applications. As a proof of concept, a 3D scaffold‐like structure is optimized as highly sensitive mechanical sensors for detecting various human motions.

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Section: D Printing Of Pthsmentioning

confidence: 87%

Bifunctional Phenol‐Enabled Sequential Polymerization Strategy for Printable Tough Hydrogels

Wei

Zhang

et al. 2022

Macromol. Rapid Commun.

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“…Consider, for example, a material that swells and contracts in response to glucose concentration and using this response to control the release of insulin. Such materials are known (Bruen et al, 2020), but even if insulin control using a materials only approach can be demonstrated convincingly, can this be presented in a manner acceptable to society as the next step on the road towards the artificial pancreas which, in the heady excitement of the 1980s, appeared to be on the cusp of happening?…”

Section: The Futurementioning

confidence: 99%

Sensors and “The internet of biochemical things”

Florea

Diamond²

2022

Front. Sens.

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In this perspective article, we consider the pathway biochemical sensing will take as the huge businesses underpinning Big Data and the Internet of Things seek new layers of highly valuable information to integrate into our increasingly digitised world. Up to now, the complexity of biochemical sensing has limited its inclusion in a manner similar to more reliable and lower cost technologies based on physical transducers. At its core, this complexity arises from the fundamental need for biochemical sensors to interact intimately at the molecular level with one or more specific components (analytes) in samples that are often highly complex and hostile to the sensors. This limits the functional lifetime of biochemical sensors to at best days or weeks or most commonly single use, making long-term embedded use-models developed for Internet of Things applications beyond reach. Nevertheless, even single use sensors can lead to “big data”, if used in large enough scale (e.g., COVID-19 diagnostics), and progress in continuous is beginning to make headway towards longer-term use models in health and environmental monitoring. New concepts exploiting advanced materials and biomimetic concepts offer opportunities to further extend the lifetime of biochemical sensing devices.

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“…Hydrogels represent 3-D hydrophilic, polymeric platforms, which hold potential preserve large quantities of water or biological fluids. Aerogels are extremely porous and provide large internal surfaces with exceptional drug delivery capabilities [190,191]. Almost all of these gels are static and brittle; however, polysaccharides form xerogels and they tend to generate transparent hydrogels, which spontaneously shape interconnected polymers.…”

Section: Drug Retention In Aerogel Layer and Hydrogelsmentioning

confidence: 99%

Current-status and applications of polysaccharides in drug delivery systems

Prasher

Sharma

Mehta

et al. 2021

Colloid and Interface Science Communications

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The polysaccharide-based advanced drug delivery system owing to their biocompatibility, ability to encapsulate the drug molecules in their interspaces, and ability to achieve a controlled release of the cargo drug molecules result in improved drug pharmacokinetics. The drug-loaded polysaccharides possess ability to evade the multidrug-resistant microbial efflux pumps by aggregation effect, whereas the drug loaded polysaccharidefabricated metal nanoparticles present an exceptional candidature for effectively transporting the drug molecules across the membrane barriers while enabling the theranostic applications at the same time. The biodegradability of polysaccharide based drug delivery systems ensure a sustained release of the encapsulated drug molecules, which minimizes the side effects caused by a burst release of the cargo therapeutics. These drug delivery systems proved highly beneficial for the NSAIDs that otherwise manifest ulcerogenic effect in the gastrointestinal tract. The large surface area of polysaccharides further provide a higher drug-loading capacity, which maintains the optimal concentration of the cargo drug at the target sites. The emerging applications of biodegradable polysaccharides in the designing of multicompartmental microspheres revolutionized tissue engineering, multi drug delivery, and cell culturing technologies. The present review deals with the current-status of polysaccharides as advanced drug delivery systems.

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3D Printed Sugar‐Sensing Hydrogels

Cited by 8 publications

References 30 publications

Bifunctional Phenol‐Enabled Sequential Polymerization Strategy for Printable Tough Hydrogels

Bifunctional Phenol‐Enabled Sequential Polymerization Strategy for Printable Tough Hydrogels

Sensors and “The internet of biochemical things”

Current-status and applications of polysaccharides in drug delivery systems

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