3D Printed Sugar‐Sensing Hydrogels

Bruen, Danielle; Delaney, Colm; Chung, Johnson; Ruberu, Kalani; Wallace, Gordon G.; Diamond, Dermot; Florea, Larisa

doi:10.1002/marc.202070020

Cited by 3 publications

(2 citation statements)

References 28 publications

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“…Generally, T gel in such a range is fast enough to achieve successful 3D printing. [ 50,51 ] Figure 5c further shows that, upon exposing the PTH precursor to the intermittent light irradiation, the increase of G' and G“ is only observed when the visible light is on. However, no change is found in these two parameters without visible light irradiation.…”

Section: Resultsmentioning

confidence: 89%

Bifunctional Phenol‐Enabled Sequential Polymerization Strategy for Printable Tough Hydrogels

Wei

Zhang

et al. 2022

Macromol. Rapid Commun.

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Hydrogels are promising material candidates in engineering soft robotics, mechanical sensors, biomimetic regenerative medicine, etc. However, developing multinetwork hydrogels with high mechanical properties and excellent printability are still challenging. Here, a bifunctional phenol‐enabled sequential polymerization (BPSP) strategy is reported to fabricate high‐performance multinetwork hydrogels under the orthogonal catalysis of efficient ruthenium photochemistry. Benefiting from this bifunctional design, phenols can sequentially polymerize with typical monomers and themselves to fabricate various phenol‐containing polymers (Ph‐Ps) and Ph‐Ps‐based multinetwork tough hydrogels, respectively. The as‐prepared hydrogels have maximum stress of 0.75 MPa and toughness of 2.2 MJ m–3 under the critical strain of 800%. These property parameters are a maximum of 16 times higher than those of the phenol‐postmodified and phenol‐free hydrogels. Moreover, the rapid coupling polymerization of phenols can shorten the gelation times of hydrogels to as low as ≈4 s, which enables its printable property for customizable applications. As a proof of concept, a 3D scaffold‐like structure is optimized as highly sensitive mechanical sensors for detecting various human motions.

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Section: Resultsmentioning

confidence: 89%

Bifunctional Phenol‐Enabled Sequential Polymerization Strategy for Printable Tough Hydrogels

Wei

Zhang

et al. 2022

Macromol. Rapid Commun.

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show abstract

“…Hydrogels are promising materials with a low elastic modulus. Nevertheless, the shape morphing of the previously reported hydrogel-based micromachines always relied on stimuli such as intense light 21,22 , temperature change 23 , pH gradients 24,25 or specific molecules 26 , which limit their applications in enclosed and delicate biological environments-for example, such stimuli are difficult to induce remotely deep within the body for medical applications. Contrastingly, magnetic fields have been widely reported as high-penetration energy sources for micromachines, making remote control feasible 8,9,11 .…”

Section: Picosprings As Real-time Piconewton-scale Force Indicatorsmentioning

confidence: 99%

3D nanofabricated soft microrobots with super-compliant picoforce springs as onboard sensors and actuators

Xu,

Wu,

Liu

et al. 2024

Nat. Nanotechnol.

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Microscale organisms and specialized motile cells use protein-based spring-like responsive structures to sense, grasp and move. Rendering this biomechanical transduction functionality in an artificial micromachine for applications in single-cell manipulations is challenging due to the need for a bio-applicable nanoscale spring system with a large and programmable strain response to piconewton-scale forces. Here we present three-dimensional nanofabrication and monolithic integration, based on an acrylic elastomer photoresist, of a magnetic spring system with quantifiable compliance sensitive to 0.5 pN, constructed with customized elasticity and magnetization distributions at the nanoscale. We demonstrate the effective design programmability of these ‘picospring’ ensembles as energy transduction mechanisms for the integrated construction of customized soft micromachines, with onboard sensing and actuation functions at the single-cell scale for microrobotic grasping and locomotion. The integration of active soft springs into three-dimensional nanofabrication offers an avenue to create biocompatible soft microrobots for non-disruptive interactions with biological entities.

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Current-status and applications of polysaccharides in drug delivery systems

Prasher

Sharma

Mehta

et al. 2021

Colloid and Interface Science Communications

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The polysaccharide-based advanced drug delivery system owing to their biocompatibility, ability to encapsulate the drug molecules in their interspaces, and ability to achieve a controlled release of the cargo drug molecules result in improved drug pharmacokinetics. The drug-loaded polysaccharides possess ability to evade the multidrug-resistant microbial efflux pumps by aggregation effect, whereas the drug loaded polysaccharidefabricated metal nanoparticles present an exceptional candidature for effectively transporting the drug molecules across the membrane barriers while enabling the theranostic applications at the same time. The biodegradability of polysaccharide based drug delivery systems ensure a sustained release of the encapsulated drug molecules, which minimizes the side effects caused by a burst release of the cargo therapeutics. These drug delivery systems proved highly beneficial for the NSAIDs that otherwise manifest ulcerogenic effect in the gastrointestinal tract. The large surface area of polysaccharides further provide a higher drug-loading capacity, which maintains the optimal concentration of the cargo drug at the target sites. The emerging applications of biodegradable polysaccharides in the designing of multicompartmental microspheres revolutionized tissue engineering, multi drug delivery, and cell culturing technologies. The present review deals with the current-status of polysaccharides as advanced drug delivery systems.

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3D Printed Sugar‐Sensing Hydrogels

Abstract: Front Cover: In article 1900610, Gordon G. Wallace, Larisa Florea, and co‐workers fabricate 3D‐printed, sugar‐sensing hydrogels. When sugar molecules are introduced into the system, the hydrogel in contact with the sugar molecules appears fluorescent.

Cited by 3 publications

References 28 publications

Bifunctional Phenol‐Enabled Sequential Polymerization Strategy for Printable Tough Hydrogels

Bifunctional Phenol‐Enabled Sequential Polymerization Strategy for Printable Tough Hydrogels

3D nanofabricated soft microrobots with super-compliant picoforce springs as onboard sensors and actuators

Current-status and applications of polysaccharides in drug delivery systems

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