3D Printing: A review on technology, role in novel dosage forms and regulatory perspective

Kg, Hemanth; Hemamanjushree, S; Abhinaya, N; Pai, Raveendra; Pai, Girish K

doi:10.5958/0974-360x.2021.00102.5

Cited by 5 publications

(2 citation statements)

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“…Three-dimensional printing [69][70][71][72][73][74][75][76][77][78][79] can solve the formulation problems of producing OFs. Currently, buccal dosage forms are reserved for potent agents due to the limited capacity of drug incorporation.…”

Section: Three-dimensional Printing Technologies For Oral Filmsmentioning

confidence: 99%

Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview

Ozon,

Sarbu,

Popovici

et al. 2023

Processes

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The interest in buccal drug delivery is under consideration due to some distinct properties compared to the traditional pharmaceutical formulations for oral administration: significantly higher bioavailability, a faster absorption rate of the drug, and substantial compliance for special needs patients. Oral films are obtained through various technologies, from conventional tools to 3D and 4D printing approaches. This minireview aims to describe the current additive manufacturing technologies in oral film fabrication, display their advantages and limitations, and discuss various formulation strategies. It also provides advanced data regarding synthetic and natural polymers used in 3D printing technologies for oral films. Moreover, it shows the most recent studies with 3D-printed orodispersible films and mucoadhesive buccal films manufactured through previously analyzed methods. Finally, conclusions and future perspectives are also briefly summarized.

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Section: Three-dimensional Printing Technologies For Oral Filmsmentioning

confidence: 99%

Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview

Ozon,

Sarbu,

Popovici

et al. 2023

Processes

View full text Add to dashboard Cite

show abstract

“…3D printing has emerged in the technological context of prototyping [1], offering the advantage of producing a unique, individualized object in a noticeably short timeframe and at a relatively low cost. Classical mass production methods provide a meager price per unit built only if that product is made in large quantities so that the cost of designing and executing models and templates divided by the number of units is low.…”

Section: Introductionmentioning

confidence: 99%

Parametric Optimization in 3D Printed Tablets Using Statistical Methods of Experimental Design

Ozon¹,

Musuc²,

Sarbu³

et al. 2023

Preprint

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Recently, 3D printing techniques gained much attention in solid dosage form production. Even though the methods are increasingly studied, there are still many challenges in establishing an accurate content of active ingredients in the final products. In the present study, new experimental design techniques and statistical software were developed to identify and optimize a formula to predict the mass of the tablet to be 3D printed before it actually is. The first step was to develop a virtual 3D object in the FreeCad Software, then, using a CURA slicer software, the G-code Format was obtained. The tablets were printed using a Cartesian 3D printer based on the generated data. Finally, adapting the object sequencing mode, a predicted drug mass value was obtained. As expected, the oblong tablet's scaling directly influences its mass. The software generates a correlation coefficient (r) of 0.84, confirming the directly proportional relationship between scaling and tablet weight. However, the r values progressively decreased, indicating a poor correlation between tablet weight and other factors: infill density percent (r = 0.403) and wall thickness (r = 0.185). After repeating the 3D printing with the values suggested by the software, tablets with a practical value of 1066 mg were obtained. Considering that the confidence interval calculated is [834.95—1165.05] and the experimental value is 1066 mg, it can be certified that the proposed model is valid.

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3D printing in drug delivery: Current trends and future prospects

Sharma¹,

Kabra²,

Thakur³

et al. 2023

International Conference on Humans and Technology: A Holistic and Symbiotic Approach to Sustainable Development: Icht 2022

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3D Printing: A review on technology, role in novel dosage forms and regulatory perspective

Cited by 5 publications

References 0 publications

Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview

Three-Dimensional Printing Technologies in Oral Films Manufacturing—A Minireview

Parametric Optimization in 3D Printed Tablets Using Statistical Methods of Experimental Design

3D printing in drug delivery: Current trends and future prospects

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