3D printing: an emerging tool for novel microfluidics and lab-on-a-chip applications

Yazdi, Alireza Ahmadian; Popma, Adam; Wong, William S. Y.; Nguyen, Tammy T.; Pan, Yayue; Xu, Jie

doi:10.1007/s10404-016-1715-4

Cited by 257 publications

(170 citation statements)

References 142 publications

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“…Additional steps must be taken using specialized airbrushing equipment to properly prepare the template for soft lithography. 19,20 More affordable printers (below $2500) can now be purchased with layer resolution (z-direction) less than 50 μm and spatial resolution in the hundreds of micrometers. 19,21 While 3D prints on this scale are inadequate for fabrication of more traditional microfluidic devices (channels with 10 – 50 μm widths), they should be ideal for well resolved millimetre-scale fluidic interfaces.…”

Section: Introductionmentioning

confidence: 99%

Macro-to-micro interfacing to microfluidic channels using 3D-printed templates: application to time-resolved secretion sampling of endocrine tissue

Brooks

Ford

Holder

et al. 2016

Analyst

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Employing 3D-printed templates for macro-to-micro interfacing, a passively operated polydimethysiloxane (PDMS) microfluidic device was designed for time-resolved secretion sampling from primary murine islets and epidiymal white adipose tissue explants. Interfacing in similar devices is typically accomplished through manually punched or drilled fluidic reservoirs. We previously introduced the concept of using hand fabricated polymer inserts to template cell culture and sampling reservoirs into PDMS devices, allowing rapid stimulation and sampling of endocrine tissue. However, fabrication of the fluidic reservoirs was time consuming, tedious, and was prone to errors during device curing. Here, we have implemented computer-aided design and 3D printing to circumvent these fabrication obstacles. In addition to rapid prototyping and design iteration advantages, the ability to match these 3D-printed interface templates with channel patterns is highly beneficial. By digitizing the template fabrication process, more robust components can be produced with reduced fabrication variability. Herein, 3D-printed templates were used for sculpting millimetre-scale reservoirs into the above-channel, bulk PDMS in passively-operated, eight-channel devices designed for time-resolved secretion sampling of murine tissue. Devices were proven functional by temporally assaying glucose-stimulated insulin secretion from <10 pancreatic islets and glycerol secretion from 2-mm adipose tissue explants, suggesting that 3D-printed interface templates could be applicable to a variety of cells and tissue types. More generally, this work validates desktop 3D printers as versatile interfacing tools in microfluidic laboratories.

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Section: Introductionmentioning

confidence: 99%

Macro-to-micro interfacing to microfluidic channels using 3D-printed templates: application to time-resolved secretion sampling of endocrine tissue

Brooks

Ford

Holder

et al. 2016

Analyst

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“…Resolutions in the µm‐range were obtained soon after the introduction of SL as a fabrication method . SL is used in various fields, including the fabrication of micromachines, microfluidic systems, tissue engineering, and bioanalysis …”

Section: Fabrication Methods For 3d Structures With Overhanging Featumentioning

confidence: 99%

Nanostructure and Microstructure Fabrication: From Desired Properties to Suitable Processes

Assenbergh

Meinders²,

Geraedts

et al. 2018

Small

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When designing a new nanostructure or microstructure, one can follow a processing-based manufacturing pathway, in which the structure properties are defined based on the processing capabilities of the fabrication method at hand. Alternatively, a performance-based pathway can be followed, where the envisioned performance is first defined, and then suitable fabrication methods are sought. To support the latter pathway, fabrication methods are here reviewed based on the geometric and material complexity, resolution, total size, geometric and material diversity, and throughput they can achieve, independently from processing capabilities. Ten groups of fabrication methods are identified and compared in terms of these seven moderators. The highest resolution is obtained with electron beam lithography, with feature sizes below 5 nm. The highest geometric complexity is attained with vat photopolymerization. For high throughput, parallel methods, such as photolithography (≈10 m h ), are needed. This review offers a decision-making tool for identifying which method to use for fabricating a structure with predefined properties.

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“…The resolution of a SLS printer is usually few tens of micrometers, typically 10 to 15 μm, which is dependent on the focus power of the laser and the particle size of the powders . Alternatively, the process is referred to as selective laser melting, when the feedstock material is a metal alloy …”

Section: D Processing Techniquesmentioning

confidence: 99%

Multifaceted polymeric materials in three‐dimensional processing (3DP) technologies: Current progress and prospects

Oderinde

Kang

et al. 2018

Polymers for Advanced Techs

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Three‐dimensional printing (3DP) technologies, which are sets of powerful deposition methods employed to fabricate 3D objects with materials in the fields of material sciences and engineering, biomedical and biocompatible structural components, automotive, aviation, and polymers, among others, are currently rapidly developing manufacturing technologies. The methods have significant advantages, which include designing flexibility, enhanced geometrical freedom, low cost, and net shape manufacture, among others, over the traditional “subtractive” method. This review highlights the major 3D printing techniques, especially in the fields of advanced polymeric material fabrication and engineering, as well as the synergy in the incorporation of different types of polymeric materials and composites in a process that will lead to an enhancement of dimensional accuracy for 3D technologies. Furthermore, composite ink systems especially polymer‐based and hydrogel‐based in tissue engineering applications are also discussed.

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3D printing: an emerging tool for novel microfluidics and lab-on-a-chip applications

Cited by 257 publications

References 142 publications

Macro-to-micro interfacing to microfluidic channels using 3D-printed templates: application to time-resolved secretion sampling of endocrine tissue

Macro-to-micro interfacing to microfluidic channels using 3D-printed templates: application to time-resolved secretion sampling of endocrine tissue

Nanostructure and Microstructure Fabrication: From Desired Properties to Suitable Processes

Multifaceted polymeric materials in three‐dimensional processing (3DP) technologies: Current progress and prospects

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