Dental prosthesis and restoration technologies have been developed in the past years. Despite the advantages of additive manufacturing, computer-aided design, and computer-aided manufacturing technologies are still the dominant type of method for fabricating prostheses. Therefore, the main goal of this study is to assess the feasibility of using indirect fused deposition modeling to fabricate dental prosthesis made of ZrSiO4-glass composites. To achieve this goal, filaments were filled by 90% of ZrSiO4 and 50 Îźm glass spheres to fabricate prosthesis. Multivariable approach was applied to evaluate the feasibility of the proposed method. Holding temperature, holding time, heating rate, and cooling rate were considered the control factors, while shrinkage, flexural strength, and process feasibility were the study responses. In addition, the flexural strength of materials was found between 25 and 85 MPa, while shrinkage fluctuated between 10 and 25%.