3D Printing for Bone Regeneration

Bandyopadhyay, Amit; Mitra, Indranath; Bose, Susmita

doi:10.1007/s11914-020-00606-2

Cited by 64 publications

(35 citation statements)

References 47 publications

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“…FDM printing requires thermoplastic materials (linear macromolecules), but most pharmaceutical grade materials do not meet the requirements. An improved technology based on FDM, called fused deposition of ceramics (FDC), gets rid of the limitations of materials used [ 7 ].…”

Section: 3d Printing Techniquesmentioning

confidence: 99%

Application and Development of Modern 3D Printing Technology in the Field of Orthopedics

Zhang

et al. 2022

BioMed Research International

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3D printing, also known as additive manufacturing, is a technology that uses a variety of adhesive materials such as powdered metal or plastic to construct objects based on digital models. Recently, 3D printing technology has been combined with digital medicine, materials science, cytology, and other multidisciplinary fields, especially in the field of orthopedic built-in objects. The development of advanced 3D printing materials continues to meet the needs of clinical precision medicine and customize the most suitable prosthesis for everyone to improve service life and satisfaction. This article introduces the development of 3D printing technology and different types of materials. We also discuss the shortcomings of 3D printing technology and the current challenges, including the poor bionics of 3D printing products, lack of ideal bioinks, product safety, and lack of market supervision. We also prospect the future development trends of 3D printing.

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Section: 3d Printing Techniquesmentioning

confidence: 99%

Application and Development of Modern 3D Printing Technology in the Field of Orthopedics

Zhang

et al. 2022

BioMed Research International

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“…Though most tissues and organs are structured with rich vascular networks, several studies indicated that the pro-vascularization of the dECM is not very promising [ 63 ]. Combining dECM bioinks with pro-angiogenic–related nanomaterials or drugs can effectively modulate the angiogenesis of recruited progenitor cells or embedded stem cells, and this phenomenon has also been demonstrated in other studies [ 155 , 156 ].…”

Section: Possible Challenges and Solutionsmentioning

confidence: 58%

Three-Dimensional Bioprinting of Decellularized Extracellular Matrix-Based Bioinks for Tissue Engineering

Zhang

et al. 2022

Molecules

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Three-dimensional (3D) bioprinting is one of the most promising additive manufacturing technologies for fabricating various biomimetic architectures of tissues and organs. In this context, the bioink, a critical element for biofabrication, is a mixture of biomaterials and living cells used in 3D printing to create cell-laden structures. Recently, decellularized extracellular matrix (dECM)-based bioinks derived from natural tissues have garnered enormous attention from researchers due to their unique and complex biochemical properties. This review initially presents the details of the natural ECM and its role in cell growth and metabolism. Further, we briefly emphasize the commonly used decellularization treatment procedures and subsequent evaluations for the quality control of the dECM. In addition, we summarize some of the common bioink preparation strategies, the 3D bioprinting approaches, and the applicability of 3D-printed dECM bioinks to tissue engineering. Finally, we present some of the challenges in this field and the prospects for future development.

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“…However, it should be recognised that such printed or bioprinted implants could also be loaded with cells prior to implantation in a clinical setting and still be classified a print-and-implant strategy. Extensive reviews are available in the literature on cell sources for bone regeneration in general [23][24][25][26][27] and more specifically for bioprinting bone implants [9,10,[28][29][30][31][32][33][34][35].…”

Section: Print-and-implant Strategies That Harness Bone's Inherent Reparative Capacitymentioning

confidence: 99%

Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors

Freeman

Burdis²,

Kelly³

2021

Trends in Molecular Medicine

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Regenerating large bone defects remains a significant clinical challenge, motivating increased interest in additive manufacturing and 3D bioprinting to engineer superior bone graft substitutes. 3D bioprinting enables different biomaterials, cell types, and growth factors to be combined to develop patientspecific implants capable of directing functional bone regeneration. Current approaches to bioprinting such implants fall into one of two categories, each with their own advantages and limitations. First are those that can be 3D bioprinted and then directly implanted into the body and second those that require further in vitro culture after bioprinting to engineer more mature tissues prior to implantation. This review covers the key concepts, challenges, and applications of both strategies to regenerate damaged and diseased bone. Current Bioprinting Strategies for Bone RegenerationSince the first US patent was awarded for 3D bioprinting (see Glossary) in 2006 (https://www.google.com/patents/US7051654), there have been significant advances in the field, particularly its application towards bone regeneration. This can be seen in the large number of publications (>600 papers) and reviews [1][2][3][4][5][6][7][8][9][10][11][12] devoted to the topic in the past 4 years alone. Advances in additive manufacturing and 3D bioprinting have had a significant impact on the fields of tissue engineering and regenerative medicine, with microextrusion, inkjet, laser-assisted bioprinting, and more recently melt-electrowriting (MEW) techniques all being used to generate implants for bone repair. In the literature there are a variety of definitions for the terms 'bioprinting' and 'bioinks', with some specifying the presence of cells as a mandatory component of the printing formulation in bioprinting [13]. For the purpose of this review, we define bioprinting as the use of 3D printing technologies to deposit cells and/or other biological factors, specifically genes, growth factors, and/or extracellular matrix (ECM) components, in a spatially controlled pattern to fabricate or regenerate living tissues and organs. Common features of a bone bioprinting strategy include a bioink (typically a hydrogel), laden with cells, genes, and/or growth factors, and a mechanical backbone of a thermopolymer or ceramic to accommodate the challenging loads experienced by the implant in situ. Extensive reviews have been written on the various technologies [1,2,4,5,[9][10][11][12][14][15][16][17] and bioinks [1,3,[6][7][8]10,18,19] under development for bone regeneration. Broadly speaking, putative therapeutics that can be derived from such technologies fall into one of two categories; first, those that can be 3D bioprinted and then directly implanted into the body (herein termed 'print-and-implant' devices), and second, those that require further in vitro culture after bioprinting (e.g., in a bioreactor) to mature the engineered tissue prior to implantation. Both approaches have their own inherent advantages and limitations. Constructs that can be biopri...

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3D Printing for Bone Regeneration

Cited by 64 publications

References 47 publications

Application and Development of Modern 3D Printing Technology in the Field of Orthopedics

Application and Development of Modern 3D Printing Technology in the Field of Orthopedics

Three-Dimensional Bioprinting of Decellularized Extracellular Matrix-Based Bioinks for Tissue Engineering

Printing New Bones: From Print-and-Implant Devices to Bioprinted Bone Organ Precursors

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