3D printing for oral drug delivery: a new tool to customize drug delivery

Pandey, Manisha; Choudhury, Hira; Fern, Joyce Lau Chui; Kee, Alice Teo Kee; Kou, Janice; Jing, Jane Lee Jia; Her, How Chiu; Yong, Hong Sin; Ming, Hon Chian; Bhattamisra, Subrat Kumar; Gorain, Bapi

doi:10.1007/s13346-020-00737-0

Cited by 90 publications

(34 citation statements)

References 89 publications

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“…However, the use of additive manufacturing also enables the preparation of small batches of customized, on-demand-prepared formulations-for example, in the treatment of patients with rare diseases or for clinical trials. The great applicability of 3D printing (3DP) in the pharmaceutical field results from the simplicity of object shape modification, which allows the production of dosage forms of complex shape and internal structure, containing one or more active pharmaceutical ingredients (APIs) [1,2]. Moreover, the differences in shape and infill density of tablets, which cannot be achieved in compressed tablets, lead to alternation in the surface-to-volume ratio and allow us to produce printlets with desired drug dosages and dissolution profiles [3][4][5].…”

Section: Introductionmentioning

confidence: 99%

Multivariate Design of 3D Printed Immediate-Release Tablets with Liquid Crystal-Forming Drug—Itraconazole

et al. 2020

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The simplicity of object shape and composition modification make additive manufacturing a great option for customized dosage form production. To achieve this goal, the correlation between structural and functional attributes of the printed objects needs to be analyzed. So far, it has not been deeply investigated in 3D printing-related papers. The aim of our study was to modify the functionalities of printed tablets containing liquid crystal-forming drug itraconazole by introducing polyvinylpyrrolidone-based polymers into the filament-forming matrices composed predominantly of poly(vinyl alcohol). The effect of the molecular reorganization of the drug and improved tablets’ disintegration was analyzed in terms of itraconazole dissolution. Micro-computed tomography was applied to analyze how the design of a printed object (in this case, a degree of an infill) affects its reproducibility during printing. It was also used to analyze the structure of the printed dosage forms. The results indicated that the improved disintegration obtained due to the use of Kollidon®CL-M was more beneficial for the dissolution of itraconazole than the molecular rearrangement and liquid crystal phase transitions. The lower infill density favored faster dissolution of the drug from printed tablets. However, it negatively affected the reproducibility of the 3D printed object.

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Section: Introductionmentioning

confidence: 99%

Multivariate Design of 3D Printed Immediate-Release Tablets with Liquid Crystal-Forming Drug—Itraconazole

et al. 2020

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“…3DP in drug production possesses patient-customized characteristics as well as accomplishes the selection of drug size, shape, and combination of different pharmaceutical ingredients, which may be more convenient for clinical applications [119] . Through 3DP technology, even the layers and percentage parameters in tablet coating, therapeutic release rates and patterns can also be predesigned, thus providing better curative effects [120,121] .…”

Section: Ai In Drug Productionmentioning

confidence: 99%

Application of Artificial Intelligence in Medicine: An Overview

et al. 2021

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Artificial intelligence (AI) is a new technical discipline that uses computer technology to research and develop the theory, method, technique, and application system for the simulation, extension, and expansion of human intelligence. With the assistance of new AI technology, the traditional medical environment has changed a lot. For example, a patient’s diagnosis based on radiological, pathological, endoscopic, ultrasonographic, and biochemical examinations has been effectively promoted with a higher accuracy and a lower human workload. The medical treatments during the perioperative period, including the preoperative preparation, surgical period, and postoperative recovery period, have been significantly enhanced with better surgical effects. In addition, AI technology has also played a crucial role in medical drug production, medical management, and medical education, taking them into a new direction. The purpose of this review is to introduce the application of AI in medicine and to provide an outlook of future trends.

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“…The least invasive, most popular method affording the greatest patient control method is oral delivery. Oral pills/tablets/capsules can be formulated using various methods, such as compression or injection molding 45,46 , 3-D printing 47,48 , extrusion 49,50 , and coating 51 to name a few. In these systems, an API is typically homogenously mixed into a matrix of controlled release agent(s) to be released via diffusion or degradation of the matrix when introduced to an external environment.…”

Section: Targeting Postoperative Pain Via Apismentioning

confidence: 99%

Degradable polymeric vehicles for postoperative pain management

Brigham

Becker

2021

Nat Commun

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Effective control of pain management has the potential to significantly decrease the need for prescription opioids following a surgical procedure. While extended release products for pain management are available commercially, the implementation of a device that safely and reliably provides extended analgesia and is sufficiently flexible to facilitate a diverse array of release profiles would serve to advance patient comfort, quality of care and compliance following surgical procedures. Herein, we review current polymeric systems that could be utilized in new, controlled post-operative pain management devices and highlight where opportunities for improvement exist.

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3D printing for oral drug delivery: a new tool to customize drug delivery

Cited by 90 publications

References 89 publications

Multivariate Design of 3D Printed Immediate-Release Tablets with Liquid Crystal-Forming Drug—Itraconazole

Multivariate Design of 3D Printed Immediate-Release Tablets with Liquid Crystal-Forming Drug—Itraconazole

Application of Artificial Intelligence in Medicine: An Overview

Degradable polymeric vehicles for postoperative pain management

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