3D Printing for Soft Tissue Regeneration and Applications in Medicine

Pantermehl, Sven; Emmert, Steffen; Foth, Aenne; Grabow, Niels; Alkildani, Said; Bader, Rainer; Barbeck, Mike; Jung, Ole

doi:10.3390/biomedicines9040336

Cited by 16 publications

(19 citation statements)

References 133 publications

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“…Two distinct deliveries may be of special interest for wound scaffolds: platelet-rich plasma (PRP) and stem cells. Besides electrospinning with prepared blend solutions containing PRP or stem cells, the scaffolds could be augmented by 3D printing technologies depositing PRP or stem cells into prepared scaffolds [25]. PRP is an orthobiologic substance of particular interest.…”

Section: Bioengineering Of Biocompatible and Biodegradable Scaffoldsmentioning

confidence: 99%

“…With the HHP method, human skin tissue may be devitalized gently thereby maintaining its biomechanical properties in the sense of devitalized allogenic skin tissue scaffolds [24]. This may even be extended by bioprinting stem cells or platelet-rich plasma or disinfectants or drugs or other wound healing enhancers into the scaffolds via 3D printing technologies [25].…”

Section: Introductionmentioning

confidence: 99%

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Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration

Emmert

Pantermehl

Foth

et al. 2021

IJMS

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Skin regeneration is a quite complex process. Epidermal differentiation alone takes about 30 days and is highly regulated. Wounds, especially chronic wounds, affect 2% to 3% of the elderly population and comprise a heterogeneous group of diseases. The prevailing reasons to develop skin wounds include venous and/or arterial circulatory disorders, diabetes, or constant pressure to the skin (decubitus). The hallmarks of modern wound treatment include debridement of dead tissue, disinfection, wound dressings that keep the wound moist but still allow air exchange, and compression bandages. Despite all these efforts there is still a huge treatment resistance and wounds will not heal. This calls for new and more efficient treatment options in combination with novel biocompatible skin scaffolds. Cold atmospheric pressure plasma (CAP) is such an innovative addition to the treatment armamentarium. In one CAP application, antimicrobial effects, wound acidification, enhanced microcirculations and cell stimulation can be achieved. It is evident that CAP treatment, in combination with novel bioengineered, biocompatible and biodegradable electrospun scaffolds, has the potential of fostering wound healing by promoting remodeling and epithelialization along such temporarily applied skin replacement scaffolds.

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Section: Bioengineering Of Biocompatible and Biodegradable Scaffoldsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Combining Biocompatible and Biodegradable Scaffolds and Cold Atmospheric Plasma for Chronic Wound Regeneration

Emmert

Pantermehl

Foth

et al. 2021

IJMS

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“…According to the American Society for Testing and Materials (ASTM) and International Standard Rule ISO-17296-2:2017, all current 3D-printing strategies are classified into seven procedures: (i) fused deposition model (FDM), also known as material extrusion, (ii) powder bed fusion, (iii) vat photopolymerization, (iv) material jetting, (v) binder jetting, (vi) sheet lamination, and (vii) directed energy deposition [71,72]. Technical specifications, potential biomedical applications and limitations have been comprehensively reviewed by others [69,[73][74][75][76].…”

Section: Overview Of 3d-printing Technology For Biomedical Applicationsmentioning

confidence: 99%

“…Consistent with these requirements, advances in additive manufacturing have enabled the development of innumerable 3D-printed models, anatomical phantoms, surgical aids, devices, and prostheses for biomedical and tissue engineering applications. Over the years, a wide variety of biomaterials and constructs have been fabricated using this technology for hard and soft tissues, including but not limited to bone, skin, cartilage, cardiovascular system, skeletal muscle, solid organs, and nerves [72,[80][81][82].…”

Section: Overview Of 3d-printing Technology For Biomedical Applicationsmentioning

confidence: 99%

New Insights into the Application of 3D-Printing Technology in Hernia Repair

et al. 2021

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Abdominal hernia repair using prosthetic materials is among the surgical interventions most widely performed worldwide. These materials, or meshes, are implanted to close the hernial defect, reinforcing the abdominal muscles and reestablishing mechanical functionality of the wall. Meshes for hernia repair are made of synthetic or biological materials exhibiting multiple shapes and configurations. Despite the myriad of devices currently marketed, the search for the ideal mesh continues as, thus far, no device offers optimal tissue repair and restored mechanical performance while minimizing postoperative complications. Additive manufacturing, or 3D-printing, has great potential for biomedical applications. Over the years, different biomaterials with advanced features have been successfully manufactured via 3D-printing for the repair of hard and soft tissues. This technological improvement is of high clinical relevance and paves the way to produce next-generation devices tailored to suit each individual patient. This review focuses on the state of the art and applications of 3D-printing technology for the manufacture of synthetic meshes. We highlight the latest approaches aimed at developing improved bioactive materials (e.g., optimizing antibacterial performance, drug release, or device opacity for contrast imaging). Challenges, limitations, and future perspectives are discussed, offering a comprehensive scenario for the applicability of 3D-printing in hernia repair.

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“…In this special issue new insights into the underlying cellular and molecular interactions of biomaterials for hard and soft tissue regeneration are presented ranging from collagen-based matrices for osteoconduction and collagen membranes for guided bone regeneration (GBR) to newly developed methodologies such as electrical stimulation of adipose-derived stem cells, vascular grafts, and bioabsorbable ossification materials for maxillofacial bone surgery [11,[16][17][18][19][20][21][22][23]. Altogether, this special issue includes studies describing novel biomaterials and innovative material processing techniques related to the healing processes of soft and hard tissues.…”

mentioning

confidence: 99%