3D Printing in alloy design to improve biocompatibility in metallic implants

Mitra, Indranath; Bose, Susmita; Dernell, William S.; Dasgupta, Nairanjana; Eckstrand, Chrissy; Herrick, Jim; Yaszemski, Michael J.; Goodman, Stuart B.; Bandyopadhyay, Amit

doi:10.1016/j.mattod.2020.11.021

Cited by 104 publications

(80 citation statements)

References 47 publications

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“…), surface roughness, corrosion resistance, and biocompatibility. Generally, implant materials consist of various polymers, ceramics, and metals (e.g., pure titanium, titanium alloys, stainless steel, and cobalt-chromium alloys) that possess adequate mechanical and corrosion-resistant properties, but which often do not exhibit the biological response that is key to successful osseointegration [ 1 , 2 , 3 ].…”

Section: Introductionmentioning

confidence: 99%

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Kravanja

Finšgar

2021

Biomedicines

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The development of bioactive coatings for orthopedic implants has been of great interest in recent years in order to achieve both early- and long-term osseointegration. Numerous bioactive materials have been investigated for this purpose, along with loading coatings with therapeutic agents (active compounds) that are released into the surrounding media in a controlled manner after surgery. This review initially focuses on the importance and usefulness of characterization techniques for bioactive coatings, allowing the detailed evaluation of coating properties and further improvements. Various advanced analytical techniques that have been used to characterize the structure, interactions, and morphology of the designed bioactive coatings are comprehensively described by means of time-of-flight secondary ion mass spectrometry (ToF-SIMS), X-ray photoelectron spectroscopy (XPS), Fourier transform infrared spectroscopy (FTIR), atomic force microscopy (AFM), scanning electron microscopy (SEM), transmission electron microscopy (TEM), 3D tomography, quartz crystal microbalance (QCM), coating adhesion, and contact angle (CA) measurements. Secondly, the design of controlled-release systems, the determination of drug release kinetics, and recent advances in drug release from bioactive coatings are addressed as the evaluation thereof is crucial for improving the synthesis parameters in designing optimal bioactive coatings.

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Section: Introductionmentioning

confidence: 99%

Analytical Techniques for the Characterization of Bioactive Coatings for Orthopaedic Implants

Kravanja

Finšgar

2021

Biomedicines

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“… SLS Bone regeneration and cell ingrowth capability. [ 81 ] Polybutylene Terephthalate (PBT) Biocompatible, degrade in aqueous media FDM and SLA Canine bones and in tissue regeneration [ 83 ] Polyurethane (PU) Biodegradable elastomer, biocompatibility SLA and DLP Cartilage tissue engineering, bone fabrication, construction of muscle and nerve scaffolds [ 84 ] Poly-vinyl alcohol (PVA) Biocompatible, biodegradable, bioinert, and semi-crystalline SLS Craniofacial defect treatment and bone tissue engineering applications, Tablets [ 85 ] Polylactic-co-glycolic acid (PLGA) Biodegradable FDM Bone regeneration animal and tissue-restoring systems [ 86 ] Stainless steel Excellent corrosion resistance and mechanical properties directed energy deposition (DED) Bone Plates, Bone screws and pins, Wires [ 87 ] Cobalt Chromium Alloys high resistance to corrosion, biocompatibility Selective Laser Melting (SLM) artificial joints (hips and knees), dental partial bridges [ 88 ] Copper alloys High thermic and electric conductivity, biostatic SLM electrical wiring [ 89 ] Titanium Matrix Composites Good resistance to oxidation, high strength at elevated temperature binder jetting Implants in the field of orthopedics and dentistry [ 90 ] Alumina (aluminum oxide) High hardness, good resistance to corrosion and temperature changes. Powder Bed Selective Laser Processing (PBSLP) General engineering applications.…”

Section: Additive Manufacturing and Printing Materialsmentioning

confidence: 99%

Additive manufacturing against the Covid-19 pandemic: a technological model for the adaptability and networking

Colorado

Mendoza²,

Lin³

et al. 2022

Journal of Materials Research and Technology

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This investigation analyzes the main contributions that additive manufacturing (AM) technology provides to the world in fighting against the pandemic COVID-19 from a materials and applications perspective. With this aim, different sources, which include academic reports, initiatives, and industrial companies, have been systematically analyzed. The AM technology applications include protective masks, mechanical ventilator parts, social distancing signage, and parts for detection and disinfection equipment [ 1 ]. There is a substantially increased number of contributions from AM technology to this global issue, which is expected to continuously increase until a sound solution is found. The materials and manufacturing technologies in addition to the current challenges and opportunities were analyzed as well. These contributions came from a lot of countries, which can be used as a future model to work in massive collaboration, technology networking, and adaptability, all lined up to provide potential solutions for some of the biggest challenges the human society might face in the future.

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“…With the assistance of computer-aided design (CAD) and surface optimisation technology, 3D-printed bone implants can now be fabricated which simultaneously possess gradient porous structures and functional surfaces, thereby greatly increasing their ability for osseointegration. [150][151] As an example, Mitra et al 152 successfully fabricated Ti-tantalum (Ta) alloy implants with multiscale structural variations by 3D…”

Section: Perspectives and Outlookmentioning

confidence: 99%