3D Printing in Drug Delivery Systems

Chakka, Jaidev L.; Salem, Aliasger K.

doi:10.2217/3dp-2019-0005

Cited by 11 publications

(5 citation statements)

References 19 publications

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“…Furthermore, 3D printing overcomes the limitations of traditional formulation techniques by tailoring tablet microstructure and altering composition, enabling the production of tablets with distinct release profiles [ 96 , 97 , 98 ]. The integration of Organ-on-a-Chip technology into 3D bioprinting ensures the precise distribution of cells, extracellular matrix, biomaterials, and circulatory systems within these models [ 72 , 73 , 98 ]. When combined with 3D printing technology, bioprinting can enhance the effectiveness of drug delivery devices.…”

Section: Discussionmentioning

confidence: 99%

“…Although 3D printing technology faces some challenges related to methodologies and materials, these issues are expected to be resolved as technology advances. The future impact of drug testing on patients is set to be significantly enhanced, with more pharmacies and hospitals equipped with 3D printing facilities for on-demand personalized pharmaceutics solutions [ 73 ].…”

Section: Discussionmentioning

confidence: 99%

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(3D) Bioprinting—Next Dimension of the Pharmaceutical Sector

Mihaylova,

Shopova,

Parahuleva

et al. 2024

Pharmaceuticals

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To create a review of the published scientific literature on the benefits and potential perspectives of the use of 3D bio-nitrification in the field of pharmaceutics. This work was performed in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines for reporting meta-analyses and systematic reviews. The scientific databases PubMed, Scopus, Google Scholar, and ScienceDirect were used to search and extract data using the following keywords: 3D bioprinting, drug research and development, personalized medicine, pharmaceutical companies, clinical trials, drug testing. The data points to several aspects of the application of bioprinting in pharmaceutics were reviewed. The main applications of bioprinting are in the development of new drug molecules as well as in the preparation of personalized drugs, but the greatest benefits are in terms of drug screening and testing. Growth in the field of 3D printing has facilitated pharmaceutical applications, enabling the development of personalized drug screening and drug delivery systems for individual patients. Bioprinting presents the opportunity to print drugs on demand according to the individual needs of the patient, making the shape, structure, and dosage suitable for each of the patient’s physical conditions, i.e., print specific drugs for controlled release rates; print porous tablets to reduce swallowing difficulties; make transdermal microneedle patches to reduce patient pain; and so on. On the other hand, bioprinting can precisely control the distribution of cells and biomaterials to build organoids, or an Organ-on-a-Chip, for the testing of drugs on printed organs mimicking specified disease characteristics instead of animal testing and clinical trials. The development of bioprinting has the potential to offer customized drug screening platforms and drug delivery systems meeting a range of individualized needs, as well as prospects at different stages of drug development and patient therapy. The role of bioprinting in preclinical and clinical testing of drugs is also of significant importance in terms of shortening the time to launch a medicinal product on the market.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

(3D) Bioprinting—Next Dimension of the Pharmaceutical Sector

Mihaylova,

Shopova,

Parahuleva

et al. 2024

Pharmaceuticals

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“…Two-photon polymerization (TPP) explores the nearinfrared femtosecond laser for solidification and developing ultraprecise 3D nanostructures with a 100 nm resolution. 68 The process needs TPP initiators, laser power, and exposure time. Although a high spatial resolution is offered by TPPbased 3D printing, it is a time-consuming fabrication, and the initiators are mainly water-insoluble, which poses a problem in biomedicine.…”

Section: D-printing Technologiesmentioning

confidence: 99%

“…Two-photon polymerization (TPP) explores the near-infrared femtosecond laser for solidification and developing ultraprecise 3D nanostructures with a 100 nm resolution . The process needs TPP initiators, laser power, and exposure time.…”

Section: D-printing Technologiesmentioning

confidence: 99%

Role of 3D Printing in the Development of Biodegradable Implants for Central Nervous System Drug Delivery

et al. 2022

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Increased life expectancy has led to a rise in age-related disorders including neurological diseases such as Alzheimer's disease and Parkinson's disease. Limited progress has been made in the development of clinically translatable therapies for these central nervous system (CNS) diseases. Challenges including the blood−brain barrier, brain complexity, and comorbidities in the elderly population are some of the contributing factors toward lower success rates. Various invasive and noninvasive ways are being employed to deliver small and large molecules across the brain. Biodegradable, implantable drug-delivery systems have gained lot of interest due to advantages such as sustained and targeted delivery, lower side effects, and higher patient compliance. 3D printing is a novel additive manufacturing technique where various materials and printing techniques can be used to fabricate implants with the desired complexity in terms of mechanical properties, shapes, or release profiles. This review discusses an overview of various types of 3D-printing techniques and illustrative examples of the existing literature on 3D-printed systems for CNS drug delivery. Currently, there are various technical and regulatory impediments that need to be addressed for successful translation from the bench to the clinical stage. Overall, 3D printing is a transformative technology with great potential in advancing customizable drug treatment in a high-throughput manner.

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“…[ 25 ] These drug delivery scaffolds can be made of both synthetic polymers such as poly‐caprolacton (PCL), and poly (lactic‐ co ‐glycolic acid) (PLGA) or natural polymers, e.g., Alg, and cellulose. [ 26 ] Overall, 3D‐bioprinting is a promising technology for the development of local drug delivery scaffolds with precise and customizable drug release profiles.…”

Section: Introductionmentioning

confidence: 99%

Avastin‐Loaded 3D‐Printed Alginate Scaffold as an Effective Antiadhesive Barrier to Prevent Postsurgical Adhesion Bands Formation

Vakilian,

Al‐Hashmi,

Al‐kindi

et al. 2024

Macromolecular Bioscience

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Post‐operative adhesion can cause complications, such as pain, and organ blockage, in the abdominal regions. To address this issue, surgical techniques, and anti‐adhesive treatments have been applied. Given the significant role of vascularization in adhesion band formation, Avastin (Ava) that targets VEGF can be applied to prevent peritoneal adhesion bands. Moreover, Alginate (Alg), a natural polysaccharide, is a promising physical barrier to prevent adhesion bands. Incorporating Ava into Alg hydrogel in a form of 3D‐printed scaffold (Alg/Ava) has potential to suppress inflammation and angiogenesis, leading to reduce peritoneal adhesion bands. Following physical, morphological, and biocompatibility evaluations, the efficacy of Alg and Ava alone and their combination in Alg/Ava on the formation of post‐surgical adhesions was evaluated. Upon confirming physical stability and sustained release of Ava, the Alg/Ava scaffold effectively diminished both the extent and strength of adhesion bands. Histopathological examination showed that the reduction in fibrosis and inflammation was responsible for preventing adhesion bands by the Alg/Ava scaffold. Additionally, the cytokine assessment revealed that this was due to the inhibition in the secretion of VEGF and IL‐6, suppressing vascularization and inflammatory pathways. This study suggests that a 3D‐printed Alg/Ava scaffold has great potential to prevent the post‐surgical adhesion bands.This article is protected by copyright. All rights reserved

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3D Printing in Drug Delivery Systems

Abstract: Three-dimensional printed drug delivery systems facilitate localized, controlled and sustained release of different active pharmaceutical ingredients "

Cited by 11 publications

References 19 publications

(3D) Bioprinting—Next Dimension of the Pharmaceutical Sector

(3D) Bioprinting—Next Dimension of the Pharmaceutical Sector

Role of 3D Printing in the Development of Biodegradable Implants for Central Nervous System Drug Delivery

Avastin‐Loaded 3D‐Printed Alginate Scaffold as an Effective Antiadhesive Barrier to Prevent Postsurgical Adhesion Bands Formation

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