3D printing nacre powder/sodium alginate scaffold loaded with PRF promotes bone tissue repair and regeneration

Liu, Bin; Hu, Cewen; Huang, Xinyue; Qin, Kaiqi; Wang, Lei; Wang, Zhilong; Liang, Jiachen; Xie, Fuqiang; Fan, Zengjie

doi:10.1039/d3bm01936e

Biomater. Sci.

2024

DOI: 10.1039/d3bm01936e

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3D printing nacre powder/sodium alginate scaffold loaded with PRF promotes bone tissue repair and regeneration

Bin Liu,

Cewen Hu,

Xinyue Huang

et al.

Abstract: Bone defect is a common complication of bone diseases, which often affects the quality of life and mental health of patients. The use of biomimetic bone scaffolds loaded with bioactive...

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Cited by 3 publications

References 84 publications

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3D Printing of Polysaccharide-Based Hydrogel Scaffolds for Tissue Engineering Applications: A Review

Tamo,

Djouonkep,

Selabi

2024

International Journal of Biological Macromolecules

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3D Printing of Polysaccharide-Based Hydrogel Scaffolds for Tissue Engineering Applications: A Review

Tamo,

Djouonkep,

Selabi

2024

International Journal of Biological Macromolecules

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Commercially available bioinks and state-of-the-art lab-made formulations for bone tissue engineering: A comprehensive review

Chiticaru,

Ioniță

2024

Materials Today Bio

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Research on Dual-Phase Composite Forming Process and Platform Construction of Radial Gradient Long Bone Scaffold

Zhang,

Wang,

Song

et al. 2024

Bioengineering

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The structure and composition of natural bone show gradient changes. Most bone scaffolds prepared by bone tissue engineering with single materials and structures present difficulties in meeting the needs of bone defect repair. Based on the structure and composition of natural long bones, this study proposed a new bone scaffold preparation technology, the dual-phase composite forming process. Based on the composite use of multiple biomaterials, a bionic natural long bone structure bone scaffold model with bone scaffold pore structure gradient and material concentration gradient changes along the radial direction was designed. Different from the traditional method of using multiple nozzles to achieve material concentration gradient in the scaffold, the dual-phase composite forming process in this study achieved continuous 3D printing preparation of bone scaffolds with gradual material concentration gradient by controlling the speed of extruding materials from two feed barrels into a closed mixing chamber with one nozzle. Through morphological characterization and mechanical property analysis, the results showed that BS-G (radial gradient long bone scaffolds prepared by the dual-phase composite forming process) had obvious pore structure gradient changes and material concentration gradient changes, while BS-T (radial gradient long bone scaffolds prepared by printing three concentrations of material in separate regions) had a discontinuous gradient with obvious boundaries between the parts. The compressive strength of BS-G was 1.00 ± 0.19 MPa, which was higher than the compressive strength of BS-T, and the compressive strength of BS-G also met the needs of bone defect repair. The results of in vitro cell culture tests showed that BS-G had no cytotoxicity. In a Sprague–Dawley rat experimental model, blood tests and key organ sections showed no significant difference between the experimental group and the control group. The prepared BS-G was verified to have good biocompatibility and lays a foundation for the subsequent study of the bone repair effect of radial gradient long bone scaffolds in large animals.

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3D printing nacre powder/sodium alginate scaffold loaded with PRF promotes bone tissue repair and regeneration

Abstract: Bone defect is a common complication of bone diseases, which often affects the quality of life and mental health of patients. The use of biomimetic bone scaffolds loaded with bioactive...

Cited by 3 publications

References 84 publications

3D Printing of Polysaccharide-Based Hydrogel Scaffolds for Tissue Engineering Applications: A Review

3D Printing of Polysaccharide-Based Hydrogel Scaffolds for Tissue Engineering Applications: A Review

Commercially available bioinks and state-of-the-art lab-made formulations for bone tissue engineering: A comprehensive review

Research on Dual-Phase Composite Forming Process and Platform Construction of Radial Gradient Long Bone Scaffold

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