3D printing of bioactive glass S53P4/sodium alginate sintering-free scaffolds

Oliveira, Rodrigo L.M.S.; Alves, Ana P.N.; Barbosa, Lucas; Silva, Adrielle de Paula; Cena, Gabrielle Lupeti de; Conceição, Kátia; Tada, Dayane Batista; Trichês, Eliandra de Sousa

doi:10.1016/j.bprint.2022.e00226

Cited by 10 publications

(2 citation statements)

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“…The milling process to obtain fine BG S53P4 particles occurred in three steps, as described in [45]. In the first step, the coarse particles of BG S53P4 were drily milled for 72 hours in a horizontal ball mill (Marconi, MA-500) using 80.8 wt.% of zirconia balls (Ø = 5 mm) and 19.2 wt.% of glass particles in a 1 L polypropylene bottle.…”

Section: Synthesis and Characterization Of Bg S53p4 Powdermentioning

confidence: 99%

“…To produce a structure with high quality and reproducibility by DIW, the ink must exhibit a continuous flow while printing, presenting a reversible softening behavior under stress, while maintaining its viscosity between 10 and 100 Pa.s at high shear rates [16,45]. Furthermore, the inks must present yield stress superior to 200 Pa to ensure structural self-support after printing.…”

Section: Rheological Behavior Of the β-Tcp And β-Tcp/s53p4 Inksmentioning

confidence: 99%

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3D Printing of β-TCP/S53P4 Scaffolds: Physicochemical, Mechanical, and Biological in vitro Evaluation

Alves

Barbosa

Oliveira

et al. 2023

J. Mater. Sci. Technol. Res.

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The focus of bone tissue engineering is on the new strategies for developing bioactive and resorbable scaffolds, which have become an alternative to the treatment of bone diseases and trauma. β-tricalcium phosphate (β-TCP) is considered resorbable and has excellent osteoconductivity. In an attempt to achieve good densification of the β-TCP scaffold and improve its biological properties, it arises the possibility of combining this material with S53P4 bioactive glass. Several techniques are used to produce bioceramic scaffolds, among them, direct ink writing (DIW) a type of additive manufacturing based on material extrusion, which allows the production of customized parts, with high complexity and good reproducibility. This work prepared β-TCP and β-TCP/S53P4 (β-TCP/10-S53P4 = 10% wt of S53P4 and β-TCP/20-S53P4 = 20% wt of S53P4) scaffolds by DIW. The ceramic inks showed pseudoplastic behavior and the 3D-printed scaffolds showed similar aspects to the digital model. Also, the β-TCP/S53P4 scaffolds (β-TCP/10-S53P4 = 1.6 ± 0.6 MPa and β-TCP/20-S53P4 = 2.1 ± 0.9 MPa) showed an increase in compressive strength when compared to β-TCP scaffolds (0.9 ± 0.1 MPa). All scaffolds showed apatite-mineralization ability in SBF after soaking for 7 and 14 days, being that the β-TCP/20-S53P4 scaffold showed a higher ability of apatite formation compared to the other scaffolds. Concerning the biological in vitro assays, all the scaffolds showed good cell viability. Thus, the β-TCP/S53P4 scaffolds showed adequate properties which become them, good candidates, to be used in bone tissue engineering.

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Section: Synthesis and Characterization Of Bg S53p4 Powdermentioning

confidence: 99%

Section: Rheological Behavior Of the β-Tcp And β-Tcp/s53p4 Inksmentioning

confidence: 99%