3D printing of biomimetic vasculature for tissue regeneration

Lei, Dong; Yang, Yang; Liu, Zenghe; Yang, Binqian; Gong, Wei; Chen, Shuo; Wang, Shaofei; Sun, Lijie; Song, Benyan; Xuan, Huixia; Mo, Xiumei; Sun, Binbin; Li, Sen; Yang, Qi; Huang, Shixing; Chen, Shiyan; Ma, Yiding; Liu, Wenguang; He, Chuanglong; Zhu, Bo; Jeffries, Eric M.; Qing, Feng‐Ling; Ye, Xiaofeng; Zhao, Qiang; You, Zhengwei

doi:10.1039/c9mh00174c

Cited by 100 publications

(76 citation statements)

References 51 publications

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“…Incorporating a salt as a sacrificial carrier material into the precursor inks represent another efficient approach to enhance the 3D printability of thermoset polymers. [ 70 ] The 3D‐printed shape before and during curing could be well retained as the sacrificial carrier materials can serve as aggregates to provide mechanical support.…”

Section: Materials Designs For 3d Printabilitymentioning

confidence: 99%

“…They also showed that incorporating sodium chloride particles into ink formulations could result in the formation of gradient porous structures after soaking in DI water, which are responsible for the rapid, programmable bending movement of 3D printed objects. [ 70 ]…”

Section: Retaining Materials Properties Of Printed Polymersmentioning

confidence: 99%

“…The use of dynamic bonds which undergo reversible breaking, exchange and reformation could be utilized to modify the printability of polymers as well as imparting various advanced functions. [ 41–58,62–67,59,68,60,69,70,72,61,73,71,82,86–88,74–81,83–85,89–133,244,258 , …”

Section: Summary and Perspectivementioning

confidence: 99%

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Extrusion 3D Printing of Polymeric Materials with Advanced Properties

et al. 2020

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3D printing is a rapidly growing technology that has an enormous potential to impact a wide range of industries such as engineering, art, education, medicine, and aerospace. The flexibility in design provided by this technique offers many opportunities for manufacturing sophisticated 3D devices. The most widely utilized method is an extrusion‐based solid‐freeform fabrication approach, which is an extremely attractive additive manufacturing technology in both academic and industrial research communities. This method is versatile, with the ability to print a range of dimensions, multimaterial, and multifunctional 3D structures. It is also a very affordable technique in prototyping. However, the lack of variety in printable polymers with advanced material properties becomes the main bottleneck in further development of this technology. Herein, a comprehensive review is provided, focusing on material design strategies to achieve or enhance the 3D printability of a range of polymers including thermoplastics, thermosets, hydrogels, and other polymers by extrusion techniques. Moreover, diverse advanced properties exhibited by such printed polymers, such as mechanical strength, conductance, self‐healing, as well as other integrated properties are highlighted. Lastly, the stimuli responsiveness of the 3D printed polymeric materials including shape morphing, degradability, and color changing is also discussed.

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Section: Materials Designs For 3d Printabilitymentioning

confidence: 99%

Section: Retaining Materials Properties Of Printed Polymersmentioning

confidence: 99%

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Extrusion 3D Printing of Polymeric Materials with Advanced Properties

et al. 2020

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“…Lei et al implanted perfusable engineered tissues on infarcted myocardium subcutaneously and epicardially. Compared to general 3D printed tissues without channels, the perfusable tissues possessed better tissue integration and treated myocardial infarction more efficiently …”

Section: Applications Of Biomimetic Vascularizationmentioning

confidence: 99%

Engineering of Hydrogel Materials with Perfusable Microchannels for Building Vascularized Tissues

Xie

Zheng

Guan

et al. 2019

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129

117

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Vascular systems are responsible for various physiological and pathological processes related to all organs in vivo, and the survival of engineered tissues for enough nutrient supply in vitro. Thus, biomimetic vascularization is highly needed for constructing both a biomimetic organ model and a reliable engineered tissue. However, many challenges remain in constructing vascularized tissues, requiring the combination of suitable biomaterials and engineering techniques. In this review, the advantages of hydrogels on building engineered vascularized tissues are discussed and recent engineering techniques for building perfusable microchannels in hydrogels are summarized, including micromolding, 3D printing, and microfluidic spinning. Furthermore, the applications of these perfusable hydrogels in manufacturing organ‐on‐a‐chip devices and transplantable engineered tissues are highlighted. Finally, current challenges in recapitulating the complexity of native vascular systems are discussed and future development of vascularized tissues is prospected.

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“…Recently, extrusion-based three-dimensional (3D) printing technology has been widely applied for producing biomaterials in regenerative medicine and promoted significant innovations [18][19][20][21][22]. During printing, viscoelastic inks are extruded out of a 3D printer's nozzle as printed fibers, which are deposited into patterns layer by layer when the nozzle moves [23,24].…”

Section: Introductionmentioning

confidence: 99%

4-Axis printing microfibrous tubular scaffold and tracheal cartilage application

Lei

Guo

et al. 2019

Sci. China Mater.

Self Cite

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Long-segment defects remain a major problem in clinical treatment of tubular tissue reconstruction. The design of tubular scaffold with desired structure and functional properties suitable for tubular tissue regeneration remains a great challenge in regenerative medicine. Here, we present a reliable method to rapidly fabricate tissueengineered tubular scaffold with hierarchical structure via 4axis printing system. The fabrication process can be adapted to various biomaterials including hydrogels, thermoplastic materials and thermosetting materials. Using polycaprolactone (PCL) as an example, we successfully fabricated the scaffolds with tunable tubular architecture, controllable mesh structure, radial elasticity, good flexibility, and luminal patency. As a preliminary demonstration of the applications of this technology, we prepared a hybrid tubular scaffold via the combination of the 4-axis printed elastic poly(glycerol sebacate) (PGS) bio-spring and electrospun gelatin nanofibers. The scaffolds seeded with chondrocytes formed tubular mature cartilage-like tissue both via in vitro culture and subcutaneous implantation in the nude mouse, which showed great potential for tracheal cartilage reconstruction.

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3D printing of biomimetic vasculature for tissue regeneration

Abstract: A simple strategy tailors perfusable and permeable hierarchical microchannel networks from diverse materials.

Cited by 100 publications

References 51 publications

Extrusion 3D Printing of Polymeric Materials with Advanced Properties

Extrusion 3D Printing of Polymeric Materials with Advanced Properties

Engineering of Hydrogel Materials with Perfusable Microchannels for Building Vascularized Tissues

4-Axis printing microfibrous tubular scaffold and tracheal cartilage application

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