3D printing of functional biomaterials for tissue engineering

Zhu, Wei; Ma, Xinwei; Gou, Maling; Mei, Deqing; Zhang, Kang; Chen, Shaochen

doi:10.1016/j.copbio.2016.03.014

Cited by 665 publications

(471 citation statements)

References 54 publications

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“…The constructs that are fabricated by laser-assisted bioprinting are often found to contain traces of contamination (comes from the absorbing layer). To avoid such contaminations absorbing layers made up of non-metallic substances are being used [59] . Furthermore, it is hard to focus the laser spot and to precisely locate the cells during printing.…”

Section: Laser-assisted Bioprintingmentioning

confidence: 99%

3D bioprinting technology for regenerative medicine applications

Sundaramurthi¹,

Rauf²,

Hauser³

2016

IJB

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Alternative strategies that overcome existing organ transplantation methods are of increasing importance because of ongoing demands and lack of adequate organ donors. Recent improvements in tissue engineering techniques offer improved solutions to this problem and will influence engineering and medicinal applications. Tissue engineering employs the synergy of cells, growth factors and scaffolds besides others with the aim to mimic the native extracellular matrix for tissue regeneration. Three-dimensional (3D) bioprinting has been explored to create organs for transplantation, medical implants, prosthetics, in vitro models and 3D tissue models for drug testing. In addition, it is emerging as a powerful technology to provide patients with severe disease conditions with personalized treatments. Challenges in tissue engineering include the development of 3D scaffolds that closely resemble native tissues. In this review, existing printing methods such as extrusion-based, robotic dispensing, cellular inkjet, laser-assisted printing and integrated tissue organ printing (ITOP) are examined. Also, natural and synthetic polymers and their blends as well as peptides that are exploited as bioinks are discussed with emphasis on regenerative medicine applications. Furthermore, applications of 3D bioprinting in regenerative medicine, evolving strategies and future perspectives are summarized.

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Section: Laser-assisted Bioprintingmentioning

confidence: 99%

3D bioprinting technology for regenerative medicine applications

Sundaramurthi¹,

Rauf²,

Hauser³

2016

IJB

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“…It was determined that 3D printing would be a relatively quick way to manufacture a series of devices for our pilot testing. Threedimensional bio-printing has emerged as a dynamic and tunable alternative to traditional biomaterials for tissue engineering [8,9]. Advancements in the field have led to astounding results mostly within the last decade.…”

Section: Introductionmentioning

confidence: 99%

Development of a Novel Suture-less Nerve Coaptation Device

Farinas¹

2018

BJSTR

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“…Laser-assisted printing commonly requires costly equipment and cannot fabricate 3D constructs [6,8] . Microextrusion-based cell printing has the drawbacks of low printing resolution as well as the side effect of flow-induced shear stress on cell viability [9][10][11] . Electrohydrodynamic jetting or printing recently attracts extensive attentions in fabricating highresolution features based on the principle of elec tro hydro dy namically induced material flows [12][13][14][15][16][17][18] .…”

Section: Introductionmentioning

confidence: 99%

Coaxial nozzle-assisted electrohydrodynamic printing for microscale 3D cell-laden constructs

Liang¹,

He²,

Chang³

et al. 2024

IJB

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Cell printing has found wide applications in biomedical fields due to its unique capability in fabricating living tissue constructs with precise control over cell arrangements. However, it is still challenging to print cell-laden 3D structures simultaneously with high resolution and high cell viability. Here a coaxial nozzle-assisted electrohydrodynamic cell printing strategy was developed to fabricate living 3D cell-laden constructs. Critical process parameters such as feeding rate and stage moving speed were evaluated to achieve smaller hydrogel filaments. The effect of CaCl 2 feeding rate on the printing of 3D alginate hydrogel constructs was also investigated. The results indicated that the presented strategy can print 3D hydrogel structures with relatively uniform filament dimension (about 80 μm) and cell distribution. The viability of the encapsulated cells was over 90%. We envision that the coaxial nozzle-assisted electrohydrodynamic printing will become a promising cell printing strategy to advance biomedical innovations. Keywords: electrohydrodynamic printing; cell printing; bioprinting; biofabrication; tissue engineering

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3D printing of functional biomaterials for tissue engineering

Cited by 665 publications

References 54 publications

3D bioprinting technology for regenerative medicine applications

3D bioprinting technology for regenerative medicine applications

Development of a Novel Suture-less Nerve Coaptation Device

Coaxial nozzle-assisted electrohydrodynamic printing for microscale 3D cell-laden constructs

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