3D printing of polymeric Coatings on AZ31 Mg alloy Substrate for Corrosion Protection of biomedical implants

Adarkwa, Eben; Kotoka, Ruben; Desai, Salil

doi:10.1002/mds3.10167

Cited by 18 publications

(8 citation statements)

References 46 publications

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“…A 3D printer builds an object by depositing the desired material layer-by-layer. The biomedical device industry has seen a rapid rise of 3D printing technologies in tissue engineering implants in recent years [ 153 , 154 , 155 , 156 , 157 , 158 , 159 , 160 , 161 , 162 , 163 , 164 ]. In 2019, Johnson et al fabricated the first MN master using a commercial 3D printer [ 60 ].…”

Section: Mn Manufacturing Methodsmentioning

confidence: 99%

“… Description Importance Limitation References Axial Force Apply force into the tip of the needle in vertical way (x-axis) Determine the failure force of the tip needle. Simulation (not accurate) [ 80 , 157 , 176 , 177 , 178 , 179 , 180 ] Transvers Force Apply force into the MN base in parallel way (y-axis) Determine the failure force of the needle base. Simulation (not accurate) [ 80 , 174 , 176 , 181 ] Insertion Test Apply the needles into a rat, pig, or human skin.…”

Section: Mn Mechanical Characterizationsmentioning

confidence: 99%

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A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications

2021

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Drug delivery through the skin offers many advantages such as avoidance of hepatic first-pass metabolism, maintenance of steady plasma concentration, safety, and compliance over oral or parenteral pathways. However, the biggest challenge for transdermal delivery is that only a limited number of potent drugs with ideal physicochemical properties can passively diffuse and intercellularly permeate through skin barriers and achieve therapeutic concentration by this route. Significant efforts have been made toward the development of approaches to enhance transdermal permeation of the drugs. Among them, microneedles represent one of the microscale physical enhancement methods that greatly expand the spectrum of drugs for transdermal and intradermal delivery. Microneedles typically measure 0.1–1 mm in length. In this review, microneedle materials, fabrication routes, characterization techniques, and applications for transdermal delivery are discussed. A variety of materials such as silicon, stainless steel, and polymers have been used to fabricate solid, coated, hollow, or dissolvable microneedles. Their implications for transdermal drug delivery have been discussed extensively. However, there remain challenges with sustained delivery, efficacy, cost-effective fabrication, and large-scale manufacturing. This review discusses different modes of characterization and the gaps in manufacturing technologies associated with microneedles. This review also discusses their potential impact on drug delivery, vaccine delivery, disease diagnostic, and cosmetics applications.

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Section: Mn Manufacturing Methodsmentioning

confidence: 99%

Section: Mn Mechanical Characterizationsmentioning

confidence: 99%

A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications

2021

Self Cite

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“…Lately, additive manufacturing, more commonly known as 3D printing, has rapidly been gaining attention as a means of manufacturing microneedles and molds [192]. In fact, the biomedical device industry has witnessed a swift adoption of 3D printing technologies for tissue engineering implants in recent years [256][257][258][259][260][261].…”

Section: Additive Manufacturingmentioning

confidence: 99%

Microneedles Patch: Design, Fabrication and Applications

Oliveira,

Teixeira,

Oliveira

et al. 2024

Preprint

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The delivery of therapeutical molecules through the skin, particularly to its deeper layers is impaired due to the stratum corneum layer, which acts as barrier to foreign substances. Thus, for the past years, scientists have focused on the development of more efficient methods to deliver molecules to skin distinct layers. Microneedles, as a new class of biomedical devices, consists on an array of microscale needles. This particular biomedical device had been drawing attention due to their ability to breach the stratum corneum, forming micro-conduits to facilitate the passage of therapeutical molecules. The microneedle device has several advantages over conventional methods, such as better medication adherence, easiness and painless self-administration. Moreover, it is possible to deliver the molecules swiftly or over time. Microneedles can vary in shape, size and composition. The design process of a microneedle device must take in account several factors, like the location delivery, the material and manufacturing process. Microneedles have been used in a large number of fields from drug and vaccine application, cosmetics, therapy, diagnosis, tissue engineering, sample extraction, cancer research, wound healing, among others.

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“…The careful choice and application of coating materials at the implant interface are key to its success. The incorporation of drugs or biofactors within polymeric encapsulation on metallic implants not only serves as a conduit for spatiotemporal bioagent[ 4 - 7 ] delivery but also provides surface modification properties to improve the biocompatibility and overall clinical performance of the implant device[ 8 - 10 ].…”

Section: Introductionmentioning

confidence: 99%

3D printing of drug-eluting bioactive multifunctional coatings for orthopedic applications

Adarkwa¹,

Roy²,

Ohodnicki³

et al. 2023

IJB

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Three-dimensional (3D) printing is implemented for surface modification of titanium alloy substrates with multilayered biofunctional polymeric coatings. Poly(lactic-co-glycolic) acid (PLGA) and polycaprolactone (PCL) polymers were embedded with amorphous calcium phosphate (ACP) and vancomycin (VA) therapeutic agents to promote osseointegration and antibacterial activity, respectively. PCL coatings revealed a uniform deposition pattern of the ACP-laden formulation and enhanced cell adhesion on the titanium alloy substrates as compared to the PLGA coatings. Scanning electron microscopy and Fourier-transform infrared spectroscopy confirmed a nanocomposite structure of ACP particles showing strong binding with the polymers. Cell viability data showed comparable MC3T3 osteoblast proliferation on polymeric coatings as equivalent to positive controls. In vitro live/dead assessment indicated higher cell attachments for 10 layers (burst release of ACP) as compared to 20 layers (steady release) for PCL coatings. The PCL coatings loaded with the antibacterial drug VA displayed a tunable release kinetics profile based on the multilayered design and drug content of the coatings. Moreover, the concentration of active VA released from the coatings was above the minimum inhibitory concentration and minimum bactericidal concentration, demonstrating its effectiveness against Staphylococcus aureus bacterial strain. This research provides a basis for developing antibacterial biocompatible coatings to promote osseointegration of orthopedic implants

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3D printing of polymeric Coatings on AZ31 Mg alloy Substrate for Corrosion Protection of biomedical implants

Cited by 18 publications

References 46 publications

A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications

A Comprehensive Review of Microneedles: Types, Materials, Processes, Characterizations and Applications

Microneedles Patch: Design, Fabrication and Applications

3D printing of drug-eluting bioactive multifunctional coatings for orthopedic applications

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